Description du projet
Le rôle des astrocytes dans la perception multisensorielle
Le cerveau dispose de la capacité unique de combiner les informations provenant des différents sens pour structurer une perception unifiée de l’environnement. Cela lui permet de réagir rapidement et avec précision aux stimuli et est essentiel à la conscience spatiale, la coordination motrice et la communication. Avec le soutien du programme Actions Marie Skłodowska-Curie, le projet AstroScope se penche sur la contributions des astrocytes au traitement des stimuli multisensoriels. L’équipe de recherche s’appuiera sur une technologie d’imagerie de pointe pour analyser les neurones et les astrocytes dans les régions sensorielles et identifier leur interaction durant la perception multisensorielle. Le projet étudiera également le rôle de l’acétylcholine dans la modulation de l’activité des astrocytes durant des tâches liées à l’attention, ce qui pourrait révéler l’influence des astrocytes sur le comportement.
Objectif
To build a coherent representation of the world, the brain combines inputs from different sensory modalities in a process named multisensory integration. Multisensory processing involves computations distributed across brain areas and cell types and it is profoundly shaped by neuromodulation. Correct perception of our multisensory environment is highly beneficial for survival as it enables accurate responses to external stimuli. Sensory neocortical areas continuously encode, integrate and elaborate multisensory information even at the primary sensory level. In these areas, multisensory neurons respond to multimodal stimuli aligned in time and space. Astrocytes integrate signals coming from neuronal populations. In turn, astrocytes can modulate neuronal activity. These cells are thus ideally placed to integrate and mediate multisensory information. Yet, if astrocytes regulate sensory perception is unclear. Additionally, due to technical limitations, most studies of multisensory processing focused on single areas separately. With this project, I will reveal the role of astrocytes in encoding multisensory stimuli across sensory areas. This will be achieved by performing, for the first time, two-photon mesoscopic imaging on both neurons and astrocytes. With advanced computational methods, I aim to decipher if information about multisensory perceptual behaviour encoded by astrocytes is complementary to that in neurons. Additionally, stimulus detection relies on external input, but is also influenced by internal states, such as attention. Acetylcholine (ACh) is correlated with attention and affects neuronal circuit responses. Hence, I will test if astrocytes are behavioural state regulators by investigating if ACh release correlates with astrocytic responses during task engagement. In conclusion, I will combine state-of-the-art molecular and optical approaches with analytical methods to understand the role of astrocytes multisensory perception influences at the mesoscale.
Champ scientifique (EuroSciVoc)
CORDIS classe les projets avec EuroSciVoc, une taxonomie multilingue des domaines scientifiques, grâce à un processus semi-automatique basé sur des techniques TLN.
CORDIS classe les projets avec EuroSciVoc, une taxonomie multilingue des domaines scientifiques, grâce à un processus semi-automatique basé sur des techniques TLN.
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Mots‑clés
Programme(s)
- HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA) Main Programme
Régime de financement
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European FellowshipsCoordinateur
16163 Genova
Italie