Project description
CO2 carbon source and mild photoredox yields valuable chiral β2-amino acids
Chiral β2-amino acids are building blocks of many pharmaceuticals. The global market for them is booming; greener synthesis methods are needed. With the support of the Marie Skłodowska-Curie Actions programme, the SYNERGISTIC project will develop energy-efficient, enantioselective, photocatalytic methods to functionalise challenging alkenes and CO2 to produce chiral 2-amino acids. A metal-free photocatalyst and a halogen atom transfer reagent will activate the alkene double bond, and a homogeneous chiral transition metal complex will simultaneously insert the CO2 molecule in an enantioselective way. The mild photoredox reaction conditions and CO2 as a C1 carbon source will enhance the sustainability of the chemicals sector and support a wide range of functionalisations.
Objective
The development of enantioselective strategies is becoming highly important as the global chiral chemicals market is expected to reach 120 billion USD by 2025. Among these chiral molecules, 2-amino acids and their derivatives are highly demanding chemicals because of their extensive uses in the synthesis of pharmaceuticals. My SYNERGISTIC proposal will envisage the functionalization of challenging alkenes and CO2 to achieve chiral 2-amino acids under energy-efficient photocatalytic conditions. To achieve this chemistry, I propose a novel approach by employing two different catalysts to activate simultaneously the double bond of alkene and to insert CO2 into the double bond. I will use a metal-free photocatalyst in combination with a halogen atom transfer (XAT) reagent to activate the double bond of alkene, and a homogeneous chiral transition metal complex to insert the CO2 molecule in a face-selective way. The mild reaction conditions of photoredox catalysis should enable to functionalize a wide range of alkenes as well as for late-stage functionalization of functionally challenging molecules found in natural products and complex pharmaceuticals. This proposal will significantly contribute to the advancement of the CO2-valorization blueprint as well as will create a groundbreaking green approach for the synthesis of chiral 2-amino acids using CO2 as a C1 synthon. More importantly, the fundamental new insights of this novel catalytic system that will be gained during this investigation will be a game-changer for the enhancement of sustainable chemistry.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences chemical sciences catalysis photocatalysis
- medical and health sciences basic medicine pharmacology and pharmacy pharmaceutical drugs
- natural sciences chemical sciences inorganic chemistry halogens
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2022-PF-01
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
95447 Bayreuth
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.