Objective
Polycystic ovary syndrome (PCOS) is a human hormonal disorder of complex etiology, characterized by reproductive, endocrine and metabolic abnormalities, which affects 15% of women of reproductive age and has a very low survival rate. Recent studies on its pathophysiology suggest that it reflects alterations in homeostatic feedback mechanisms between the ovaries, adipose tissue, and hypothalamic circuits that develop during embryogenesis. Despite its high prevalence and significant impact on health, there are no effective treatments for PCOS due to its complex etiology.
The development of new animal models displaying features of human PCOS is an unmet need because classical mouse models of PCOS have relied on its induction with androgen excess, providing only very limited insight into the pathogenesis of PCOS.
In a genetic screen against secretable and transmembrane proteins involved in tissue-to-tissue communication, the host lab has identified new genes that act as sensors of the amount of body fat in the larval prothoracic endocrine gland of Drosophila. This gland corresponds to the neurosecretory part of the mammalian hypothalamus and mutants in these genes are characterized by PCOS.
The main objective of this proposal is to characterize how cell communication in the neuroendocrine-adipose tissue-ovary axis is responsible for the uncontrolled proliferation of gonadal germ cells. The underlying PCOS will be studied using single-cell genomic approaches, metabolomics, and genetic studies on the different elements that make up this axis. By elucidating the molecular/hormonal mechanisms involved in brain-adipose tissue-ovary communication in normal development and disease, I hope to better define the pathogenesis and development of targeted therapies against PCOS.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences basic medicine physiology pathophysiology
- natural sciences biological sciences biochemistry biomolecules proteins
- natural sciences biological sciences developmental biology
- engineering and technology electrical engineering, electronic engineering, information engineering electronic engineering sensors
- medical and health sciences health sciences nutrition obesity
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2022-PF-01
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
28006 MADRID
Spain
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.