Descrizione del progetto
Modelli personalizzati potrebbero consentire un trattamento ortesico personalizzato dell’osteoartrite del ginocchio
Più di 300 milioni di persone soffrono di osteoartrite del ginocchio (KOA, knee osteoarthritis), il che rende urgente la necessità di ortesi del ginocchio più efficaci e confortevoli. Gli attuali modelli muscolo-scheletrici e i più recenti modelli di accoppiamento uomo-ortesi non colgono adeguatamente i meccanismi biomeccanici delle interazioni paziente-ortesi, in particolare per quanto riguarda la distribuzione anomala del carico tra i compartimenti mediale e laterale del ginocchio, il principale fattore biomeccanico associato all’insorgere e alla progressione della KOA. Con il sostegno del programma di azioni Marie Skłodowska-Curie, il progetto KOA-Orthosis svilupperà modelli muscolo-scheletrici di accoppiamento paziente-ortesi specifici per ogni soggetto, consentendo l’analisi dettagliata delle interazioni critiche. Il progetto utilizzerà poi le simulazioni per progettare un prototipo di ortesi del ginocchio basato sui modelli di interazione sviluppati e valutarne le prestazioni.
Obiettivo
Knee osteoarthritis (KOA) is a prevalent, chronic, degenerative, and multifactorial disease associated with pain, stiffness, and physical disability, and it is a significant public health problem in the world. Abnormal load distribution between knee medial and lateral compartments has been designated as the main biomechanical factor for the initiation and progression of KOA. Accurate quantification of internal knee contact force during daily living activities is significant for understanding the biomechanical mechanism of patient-orthosis interaction and improving the treatment with knee orthotics.
During the passing years, some subject-specific musculoskeletal models have been proposed to improve the prediction accuracy of internal knee contact force. However, approximations such as linear scaling, point contact assumptions, absence of ligaments, inaccurate muscle models, and absence of proper knee models are present in most models. Additionally, new human-orthosis coupling models have been proposed during the past years. However, disadvantages such as a relatively simple human model, non-patient model, and rigid contact between human and orthosis, remain. Therefore, the current musculoskeletal models and human-orthosis coupling models are not suitable for deeply studying the biomechanical mechanism of patient-orthosis interaction.
The goal of the research will focus on (1) developing a subject-specific patient-orthosis coupling musculoskeletal model considering subject-specific geometric models of bones, cartilages and meniscus, knee ligaments, muscle modelling, natural contact, and patient’s disease progression; (2) analyzing the biomechanical relationship between the applied orthopedic moment and internal contact forces of knee medial and lateral compartments, and understanding the interaction between the knee orthosis and KOA patients; (3) simulation-based design and evaluation of a prototype knee orthosis based on the developed interaction models.
Campo scientifico
Parole chiave
Programma(i)
- HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA) Main Programme
Meccanismo di finanziamento
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European FellowshipsCoordinatore
100 44 Stockholm
Svezia