Skip to main content
Aller à la page d’accueil de la Commission européenne (s’ouvre dans une nouvelle fenêtre)
français fr
CORDIS - Résultats de la recherche de l’UE
CORDIS

Self-Monitoring of Prostate cancer by Automated hybrid Recognition of Exosomal miRNA: toward personalized analytical Tool

Objectif

"Tumor-derived circulating exosomes are a suitable, readily accessible reservoir of cancer biomarkers for disease process analysis. The microRNAs (miRNAs) inside the exosomes provide information about the mechanisms of change in cancer of affected individuals. Quantitative determination of miRNAs in the exosome, a clinical area of unmet need, is tempting but challenging. The main objectives of the proposal are to develop a non-invasive, affordable, user-friendly, and deliverable platform that can measure mutant miRNA-107 in prostate cancer (PCa)-associated exosomes with unmatched accuracy, combining a hybrid oligonucleotides (ONs)-nanomaterials integrated composite system with an E-μPAD. The proposed platform offers ""Self-Monitoring of Prostate Cancer by Automated hybrid Recognition of Exosomal miRNA: towards personalized analytical Tool"" named "" SMART"". SMART provides a universal technology for non-invasive PCa diagnosis and quantitative tracking of miRNA levels in cancer-derived exosomes in a very simple and effortless manner in biofluids such as serum and urine. The novelty of the proposed interdisciplinary project work will evolve into the next generation of intelligent point-of-care (POC) tools for precision medicine. This proposal will contribute to the sustainability of the healthcare system by enabling patients to stratify and/or predict disease, thereby improving clinical decision making. This MSCA PF will be carried out at the University of Naples, Italy, will provide the researcher with advanced technical training in exosome isolation, PCR and DNA sequencing, molecular biology, microfluidics, pathology, nanomaterials synthesis, analytical techniques, proposal and manuscript preparation, and academic supervision in research management. The proposed multidisciplinary collaboration in the SMART project has resulted in a new generation of smart medical devices with functions comparable to existing highly specialized hospital devices."

Champ scientifique (EuroSciVoc)

Mots‑clés

Programme(s)

Thème(s)

Régime de financement

HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships

Voir tous les projets financés dans le cadre de ce programme de financement

Appel à propositions

(s’ouvre dans une nouvelle fenêtre) HORIZON-MSCA-2022-PF-01

Voir tous les projets financés au titre de cet appel

Coordinateur

UNIVERSITA DEGLI STUDI DI NAPOLI FEDERICO II
Contribution nette de l'UE
€ 172 750,08
Coût total
Aucune donnée