Project description
Personalised bioelectronic dressings for faster wound healing
Chronic wounds pose a major challenge to healthcare systems, leading to prolonged treatments and high costs. Healing is often delayed, increasing the risk of infection and complications. While artificial scaffolds offer temporary solutions, nothing matches the protective strength of naturally restored skin. Direct current stimulation (DCS) has shown great promise in accelerating wound closure, but past clinical studies failed due to imprecise dosage control. With this in mind, the ERC-funded ProBER project will develop personalised bioelectronic wound dressings with biocompatible, metal-free DCs electrodes. Using LIDAR 3D scanning and impedance sensors, the dressings will adapt stimulation to each patient’s wound. This breakthrough could pave the way for clinical translation, improving wound healing outcomes across Europe.
Objective
Care of chronic wounds constitutes an enormous socioeconomic burden to the European Healthcare system calling for new strategies to support healing for wounds at risk. As a restored epithelium will outperform any artificial scaffold in protecting the underlying tissue, fast re-epithelialization is the primary goal. In culture models of wound healing, we have shown that direct current stimulation (DCs) makes epithelial ruptures close up to three times faster, and that the key to success is dosage. This aspect is overlooked in previous clinical studies. Typically, DCs thresholds established in cultures are lost in translation, because of the lack of technologies able to support DCs on the skin.
In ProBER we will change this. We will exploit technologies for making conformal, metal free, biocompatible DCs electrodes for skin developed in the ERC StG SPEEDER. By focussing on personalisation of the bioelectronic wound dressing we will ensure that the same efficient parameter space established in culture models can be precisely replicated on actual wounds. Our goal is a fabrication pipeline with wound dressings tailored to the wound. We will collect information on wound size and shape using LIDAR 3D scanning, and feed this, as well as impedance measurements, to an automated personalisation algorithm. Personalisation extends beyond fabrication as the ProBER wound dressing will include integrated impedance sensors to ensure that DCs is adapted to the healing progress. In ProBER, we will prepare our promising concept for subsequent clinical studies, which requires a functional concept for fabrication and proof-of-concept demonstration. We will co-develop our wound dressing together with stakeholders in healthcare, and work to protect IP, recruit strategic partners and form alliances for clinical translation.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- engineering and technology electrical engineering, electronic engineering, information engineering electronic engineering sensors
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.1 - European Research Council (ERC)
MAIN PROGRAMME
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Topic(s)
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-ERC-POC - HORIZON ERC Proof of Concept Grants
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) ERC-2022-POC2
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
412 96 Goteborg
Sweden
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