Enabling advances in diagnosis, patient stratification and treatment for dilated cardiomyopathy patients and families.

Project Information

DCM-NEXT

Grant agreement ID: 101115416

DOI 10.3030/101115416

EC signature date 20 June 2023

Start date 1 October 2023

End date 30 September 2027

Funded under

• The European Innovation Council (EIC)

Total cost € 4 137 718,75

EU contribution € 4 137 668,75

Coordinated by

STICHTING AMSTERDAM UMC
Netherlands

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Documents, reports (1)

Plan for Dissemination and Communication Activities

Plan for project communication and dissemination activities.

Publications

Peer reviewed articles (8)

Causal inference in the field of arrhythmia: An introduction to mendelian randomization

Author(s): Eva Lukas, Margot van de Weijer, Jacob Bergstedt, Connie R. Bezzina, Jorien L. Treur
Published in: Heart Rhythm, 2024, ISSN 1547-5271
Publisher: Elsevier BV
DOI: 10.1016/j.hrthm.2024.07.015

Druggable proteins influencing cardiac structure and function: Implications for heart failure therapies and cancer cardiotoxicity

Author(s): Schmidt, Amand F.; Bourfiss, Mimount; Alasiri, Abdulrahman; Puyol-Anton, Esther; Chopade, Sandesh; van Vugt, Marion; van der Laan, Sander W.; Gross, Christian; Clarkson, Chris; Henry, Albert; Lumbers, Tom R.; van der Harst, Pim; Franceschini, Nora; Bis, Joshua C.; Velthuis, Birgitta K.; te Riele, Anneline S. J. M.; Hingorani, Aroon D.; Ruijsink, Bram; Asselbergs, Folkert W.; van Setten, Jessica; Finan, Chris
Published in: Science Advances, 2023, ISSN 2375-2548
Publisher: American Association for the Advancement of Science
DOI: 10.1126/sciadv.add4984

Genome-wide association study reveals mechanisms underlying dilated cardiomyopathy and myocardial resilience

Author(s): Sean J Jurgens, Joel T Rämö, Daria R Kramarenko, Leonoor F J M Wijdeveld, Jan Haas, Mark D Chaffin, Sophie Garnier, Liam Gaziano, Lu-Chen Weng, Alex Lipov, Sean L Zheng, Albert Henry....and Connie R Bezzina
Published in: Nature Genetics, 2024, ISSN 1061-4036
Publisher: Nature Publishing Group
DOI: 10.1038/s41588-024-01975-5

Integrating metabolomics and proteomics to identify novel drug targets for heart failure and atrial fibrillation

Author(s): Marion van Vugt, Chris Finan, Sandesh Chopade, Rui Providencia, Connie R. Bezzina, Folkert W. Asselbergs, Jessica van Setten, A. Floriaan Schmidt
Published in: Genome Medicine, Issue 16, 2024, ISSN 1756-994X
Publisher: Springer Science and Business Media LLC
DOI: 10.1186/s13073-024-01395-4

The emerging role of clonal haematopoiesis in the pathogenesis of dilated cardiomyopathy

Author(s): Job A J Verdonschot, Jose J Fuster, Kenneth Walsh, Stephane R B Heymans
Published in: European Heart Journal, 2024, ISSN 0195-668X
Publisher: Oxford University Press (OUP)
DOI: 10.1093/eurheartj/ehae682

Top stories on genome-wide association studies

Author(s): Connie Bezzina, Alex Lipov, Roddy Walsh
Published in: Heart Rhythm, Issue 21, 2024, ISSN 1547-5271
Publisher: Elsevier BV
DOI: 10.1016/j.hrthm.2024.06.005

Biallelic Loss of Function Variants in Myocardial Zonula Adherens Protein Gene (MYZAP) Cause a Severe Recessive Form of Dilated Cardiomyopathy

Author(s): Juan Pablo Ochoa, Laura Lalaguna, Jesús G. Mirelis, Fernando Dominguez, Esther Gonzalez-Lopez, Clara Salas, Gaston Roustan, Kathryn A. McGurk, Sean L. Zheng, Paul J.R. Barton, James S. Ware, María Victoria Gómez-Gaviro, Enrique Lara-Pezzi, Pablo Garcia-Pavia
Published in: Circulation: Heart Failure, Issue 17, 2024, ISSN 1941-3289
Publisher: Ovid Technologies (Wolters Kluwer Health)
DOI: 10.1161/CIRCHEARTFAILURE.123.011226

Cytotoxic T-Cells Drive Outcome in Inflammatory Dilated Cardiomyopathy

Author(s): Maurits A. Sikking, Daniel Harding, Michiel T.H.M. Henkens, Sophie L.V.M. Stroeks, Max F.G.H.M. Venner, Bastien Nihant, Rick E.W. van Leeuwen, Silvia Fanti, Xiaofei Li, Pieter van Paassen, Christian Knackstedt, Hans-Peter Brunner-la Rocca, Vanessa P.M. van Empel, Job A.J. Verdonschot, Federica M. Marelli-Berg, Stephane R.B. Heymans
Published in: Circulation Research, 2024, ISSN 0009-7330
Publisher: Ovid Technologies (Wolters Kluwer Health)
DOI: 10.1161/CIRCRESAHA.124.325183