Enabling advances in diagnosis, patient stratification and treatment for dilated cardiomyopathy patients and families.

Informazioni relative al progetto

DCM-NEXT

ID dell’accordo di sovvenzione: 101115416

DOI

10.3030/101115416

Data della firma CE 20 Giugno 2023

Data di avvio 1 Ottobre 2023

Data di completamento 30 Settembre 2027

Finanziato da

• The European Innovation Council (EIC)

Costo totale

€ 4 137 718,75

Contributo UE

€ 4 137 668,75

Coordinato da

STICHTING AMSTERDAM UMC
Netherlands

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Documents, reports (2)

Plan for Dissemination and Communication Activities

Plan for project communication and dissemination activities.

Website and project logo

Website and project logo information with also social media links

Data Management Plan (1)

Data Management Plan

Development of the data management plan.

Pubblicazioni

Peer reviewed articles (8)

Causal inference in the field of arrhythmia: An introduction to mendelian randomization

Autori: Eva Lukas, Margot van de Weijer, Jacob Bergstedt, Connie R. Bezzina, Jorien L. Treur
Pubblicato in: Heart Rhythm, 2024, ISSN 1547-5271
Editore: Elsevier BV
DOI: 10.1016/j.hrthm.2024.07.015

Druggable proteins influencing cardiac structure and function: Implications for heart failure therapies and cancer cardiotoxicity

Autori: Schmidt, Amand F.; Bourfiss, Mimount; Alasiri, Abdulrahman; Puyol-Anton, Esther; Chopade, Sandesh; van Vugt, Marion; van der Laan, Sander W.; Gross, Christian; Clarkson, Chris; Henry, Albert; Lumbers, Tom R.; van der Harst, Pim; Franceschini, Nora; Bis, Joshua C.; Velthuis, Birgitta K.; te Riele, Anneline S. J. M.; Hingorani, Aroon D.; Ruijsink, Bram; Asselbergs, Folkert W.; van Setten, Jessica; Finan, Chris
Pubblicato in: Science Advances, 2023, ISSN 2375-2548
Editore: American Association for the Advancement of Science
DOI: 10.1126/sciadv.add4984

Genome-wide association study reveals mechanisms underlying dilated cardiomyopathy and myocardial resilience

Autori: Sean J Jurgens, Joel T Rämö, Daria R Kramarenko, Leonoor F J M Wijdeveld, Jan Haas, Mark D Chaffin, Sophie Garnier, Liam Gaziano, Lu-Chen Weng, Alex Lipov, Sean L Zheng, Albert Henry....and Connie R Bezzina
Pubblicato in: Nature Genetics, 2024, ISSN 1061-4036
Editore: Nature Publishing Group
DOI: 10.1038/s41588-024-01975-5

Integrating metabolomics and proteomics to identify novel drug targets for heart failure and atrial fibrillation

Autori: Marion van Vugt, Chris Finan, Sandesh Chopade, Rui Providencia, Connie R. Bezzina, Folkert W. Asselbergs, Jessica van Setten, A. Floriaan Schmidt
Pubblicato in: Genome Medicine, Numero 16, 2024, ISSN 1756-994X
Editore: Springer Science and Business Media LLC
DOI: 10.1186/s13073-024-01395-4

The emerging role of clonal haematopoiesis in the pathogenesis of dilated cardiomyopathy

Autori: Job A J Verdonschot, Jose J Fuster, Kenneth Walsh, Stephane R B Heymans
Pubblicato in: European Heart Journal, 2024, ISSN 0195-668X
Editore: Oxford University Press (OUP)
DOI: 10.1093/eurheartj/ehae682

Top stories on genome-wide association studies

Autori: Connie Bezzina, Alex Lipov, Roddy Walsh
Pubblicato in: Heart Rhythm, Numero 21, 2024, ISSN 1547-5271
Editore: Elsevier BV
DOI: 10.1016/j.hrthm.2024.06.005

Biallelic Loss of Function Variants in Myocardial Zonula Adherens Protein Gene (MYZAP) Cause a Severe Recessive Form of Dilated Cardiomyopathy

Autori: Juan Pablo Ochoa, Laura Lalaguna, Jesús G. Mirelis, Fernando Dominguez, Esther Gonzalez-Lopez, Clara Salas, Gaston Roustan, Kathryn A. McGurk, Sean L. Zheng, Paul J.R. Barton, James S. Ware, María Victoria Gómez-Gaviro, Enrique Lara-Pezzi, Pablo Garcia-Pavia
Pubblicato in: Circulation: Heart Failure, Numero 17, 2024, ISSN 1941-3289
Editore: Ovid Technologies (Wolters Kluwer Health)
DOI: 10.1161/CIRCHEARTFAILURE.123.011226

Cytotoxic T-Cells Drive Outcome in Inflammatory Dilated Cardiomyopathy

Autori: Maurits A. Sikking, Daniel Harding, Michiel T.H.M. Henkens, Sophie L.V.M. Stroeks, Max F.G.H.M. Venner, Bastien Nihant, Rick E.W. van Leeuwen, Silvia Fanti, Xiaofei Li, Pieter van Paassen, Christian Knackstedt, Hans-Peter Brunner-la Rocca, Vanessa P.M. van Empel, Job A.J. Verdonschot, Federica M. Marelli-Berg, Stephane R.B. Heymans
Pubblicato in: Circulation Research, 2024, ISSN 0009-7330
Editore: Ovid Technologies (Wolters Kluwer Health)
DOI: 10.1161/CIRCRESAHA.124.325183