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Enabling advances in diagnosis, patient stratification and treatment for dilated cardiomyopathy patients and families.

Project description

A cure for dilated cardiomyopathy

Dilated cardiomyopathy (DCM) is a condition known to cause heart failure and sudden cardiac death. It often affects young adults, with a prevalence of up to 1 in 250 individuals. Currently, medical treatment is limited to managing symptoms, and the only curative option is an invasive heart transplantation at the end-stage of DCM. The EU-funded DCM-NEXT project will address the gaps in understanding DCM's genetic architecture, genes, and genetic variants. This project is supported by world-renowned experts from various fields such as phenotyping, cardio genomics, artificial intelligence, and others. Their main objectives include identifying and validating targets involved in the pathogenesis of DCM, revolutionising diagnostic testing, enabling precise risk prediction, and developing novel therapies for DCM.

Objective

Dilated Cardiomyopathy (DCM) is a heart muscle disorder characterised by thinning and stretching of the heart ventricles, making it harder for the heart to pump blood (systolic dysfunction). This disorder, with an estimated prevalence of up to 1/250, predominantly affects younger adults. It is associated with significant morbidity and mortality, including heart failure and sudden cardiac death, with end-stage DCM being the leading indication for heart transplantation.

The current disease burden in DCM is largely attributable to two important gaps in scientific knowledge: Firstly, our understanding of the aetiology and genetic architecture of DCM remains limited, hindering the utility of genetic testing in clinical patient management. Secondly, there are limited therapeutic options for DCM patients. Existing therapies are generic and target symptoms. No curative treatments exist, apart from invasive heart transplantation and there are no approved therapies targeting underlying molecular disease mechanisms.

A fuller understanding of the genetic architecture of DCM and knowledge of the genes and genetic variants involved are critically needed to provide solutions for these unmet medical needs.

The DCM-NEXT consortium combines world-leading interdisciplinary expertise and resources of 8 investigators in the fields of DCM, deep clinical phenotyping, cardiogenomics, cardiac transcriptomics, artificial intelligence, in silico drug target discovery and functional studies. They will uniquely leverage their unparalleled cohort of 11,750 DCM probands and relatives with extensive clinical and omics data.

Through cutting-edge genomic and cardiac transcriptomic studies, the project aims to (1) revolutionise genetic testing and patient stratification for more precise prediction of disease onset, progression and risk of major adverse cardiac events; and (2) accelerate development of novel therapies by identifying and validating targets involved in pathogenesis of DCM.

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Topic(s)

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HORIZON-EIC - HORIZON EIC Grants

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Call for proposal

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(opens in new window) HORIZON-EIC-2022-PATHFINDERCHALLENGES-01

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Coordinator

STICHTING AMSTERDAM UMC
Net EU contribution

Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.

€ 2 032 900,00
Total cost

The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.

€ 2 032 900,00

Participants (6)

Partners (1)

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