Descripción del proyecto
Comprender las decisiones espaciales basadas en mapas cerebrales en animales
Los animales navegan por su entorno utilizando mapas cognitivos internos. Sin embargo, aún no se conocen del todo los mecanismos que subyacen a su proceso de toma de decisiones. Las decisiones relativas a la evaluación de la localización dependen de la combinación de propiedades aprendidas e inferidas, pero el almacenamiento preciso de estos mapas en el cerebro, así como su papel para facilitar la toma de decisiones, sigue sin estar claro. Teniendo esto en cuenta, en el proyecto ChoiceSpace, financiado por el Consejo Europeo de Investigación, se examinará cómo los animales seleccionan los lugares de recompensa, evalúan los costes y beneficios de varias rutas y construyen mapas cognitivos internos. Su equipo empleará la rata como modelo animal y dispositivos a medida y técnicas de aprendizaje automático para registrar la actividad neuronal. Además, llevará a cabo experimentos de perturbación optogenética para evaluar el papel causal de regiones cerebrales específicas en la toma de decisiones espaciales. Los resultados revelarán el modo en que el cerebro procesa las decisiones espaciales basadas en mapas.
Objetivo
One of the hallmarks of our cognition is the ability to decide by thinking several steps ahead using an internal cognitive map. In the wild, map-based decisions can enable animals to select a target location based on the amount of food available and the cost of reaching there. But how are such decisions made? For example, how does the brain evaluate a nearby location with a small amount of food versus a distal location with more food? What if the route to the distal location is steep? Such spatial decisions are unique because evaluating a location depends not only on the learned properties of the location but also on inferred properties, like distance, that are estimated from an internal map. However, where or how in the brain are these maps stored and how they enable spatial decision-making remains unknown. Here we will address this question through three specific aims. First, we will test how animals choose among reward sites located at various distances, each dispensing different reward amounts. Next, we will investigate how animals deduce the costs and benefits associated with different trajectories in an environment to make an informed decision. Finally, we will decipher how these internal cognitive maps are formed. These questions will be studied using novel behavior paradigms with rats as the animal model. As rats perform these tasks, simultaneous activity of hundreds of neurons will be recorded from multiple brain regions using novel custom-built devices. To study the internal map formation and the mechanism of map-based decision-making, the neural activity will be analyzed using state-of-the-art machine learning techniques. Finally, the causal role of the corresponding brain regions in spatial decision-making will be tested using optogenetic perturbation experiments. This multi-disciplinary approach will uncover how the brain makes map-based spatial decisions – a phenomenon that remains unexplored but yet of great importance across species.
Palabras clave
Programa(s)
- HORIZON.1.1 - European Research Council (ERC) Main Programme
Régimen de financiación
HORIZON-ERC - HORIZON ERC GrantsInstitución de acogida
91904 Jerusalem
Israel