Descripción del proyecto
Terapia con plasma gaseoso para la piel precancerosa
La queratosis actínica es una afección cutánea común caracterizada por la presencia de manchas o lesiones ásperas en la piel. Se considera una afección precancerosa y un pequeño porcentaje de las lesiones de queratosis actínica evolucionan hasta convertirse en carcinoma de células escamosas, un tipo de cáncer de piel. Financiado por las acciones Marie Skłodowska-Curie, el equipo del proyecto PlasmaACT pretende tratar la queratosis actínica mediante terapia de plasma gaseoso, un tipo de gas ionizado compuesto por iones, electrones y partículas neutras. En aire ambiente, estos plasmas generan radicales libres. Dicha prometedora tecnología ya ha encontrado aplicación en la cicatrización de heridas y el tratamiento de otras afecciones dermatológicas. Los investigadores de PlasmaACT harán avanzar esta tecnología para apoyar la prevención del cáncer de piel y ofrecer un tratamiento eficaz y asequible para la queratosis actínica.
Objetivo
The quality of human (and veterinary) health care systems substantially depends on key innovations. Often, these were driven by the field of physics, followed by interdisciplinary and inter-sectorial actions in engineering, chemistry, biology, and medicine, such as X-rays in medical diagnostics, ionizing radiation in cancer treatment, and femtosecond lasers for precision surgery. Medical gas plasma technology was introduced to human health care a decade ago. Today, accredited medical plasma devices are in daily operation in dozen dermatology centers in middle Europe to improve wound healing. In addition, physical plasmas were shown to inactivate cancerous cells. Actinic Keratosis is a skin disease affecting millions of Europeans and making them prone to invasive and deadly skin cancer. Many of the available treatment options are associated with low efficacy, pain, risks, and/or high costs. Medical gas plasma technology is operated at body temperature and applied painlessly, cost-effectively, and without notable side effects. Gas plasma has been suggested to be active on high-grade cancer cells, but its activity against premalignant cells, as in Actinic Keratosis, is unknown. By using beyond state-of-the-art plasma multijet technology, the primary technical objective of PlasmACT – Plasma against Actinic Keratosis – is to support skin cancer prevention by medical gas plasma therapy of Actinic Keratosis. PlasmACT does so by educating a new generation of application-oriented scientists that are exposed to questions and findings from different scientific fields (interdisciplinary from physics over chemistry and biology to medicine) and capable of addressing questions in view of both academic as well as business needs (inter-sectoral) while incorporated in a vivid and productive environment across borders and cultures (international).
Ámbito científico
Palabras clave
Programa(s)
- HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA) Main Programme
Régimen de financiación
HORIZON-TMA-MSCA-DN - HORIZON TMA MSCA Doctoral NetworksCoordinador
17489 Greifswald
Alemania