Project description
Understanding the complex dynamics of mobile genetic elements
Mobile genetic elements (MGEs), first described in the maize genome in the 1940s, comprise a plethora of genomic sequences or DNA that can move within and between chromosomes, and even between bacteria and species. Scientists recently discovered that bacterial viruses (phages) can communicate extracellularly with their offspring through a MGE peptide-based system called arbitrium, guiding decisions including transitions between quiescence and virulence. Furthermore, this system is present in other MGEs. The molecular basis of these remarkable communication systems is unknown, as is their prevalence and ecological function. The ERC-funded TalkingPhages project will address these gaps using tools from genetics, biochemistry and eco-evolutionary dynamics.
Objective
Communication between organisms is one of the most sophisticated forms of social interactions. It has been recently discovered that bacterial viruses (phages) show multiple social attributes including the ability to communicate extracellularly with their progenies through a peptide-based system called arbitrium. This system is utilized by phages to guide life-cycle decisions, such as the transitions between their quiescence and virulence states. It has subsequently become clear that this system is not exclusive to phages but is also present in other mobile genetic elements (MGEs) and that its underlying design and function has diversified considerably. Despite the wide-ranging impact of these discoveries, the molecular basis of these new systems of communication, and their function in different MGEs, remain to be deciphered. More importantly, although it has been proposed that phages only communicate with their progeny, our preliminary results indicate that the arbitrium system can be used by phages and other elements to communicate with unrelated MGEs, sometimes present in different bacterial species. However, the prevalence and ecological role of this unprecedented inter-MGE communication is unclear. In the TalkingPhages project, we’ll explore all these questions and establish the molecular basis used by arbitrium systems to shape MGE diversity, interactions amongst MGEs and bacterial ecology and evolution. Our team combines expertise in MGEs and communication systems using tools from genetics (Penadés), biochemistry (Marina) and eco-evolutionary dynamics (Eldar). By exposing the multi-layered network of communications between MGEs, which is amenable for exploration on multiple levels of resolution, this project would set a milestone in understanding the complex eco-evolutionary dynamics of MGEs and the relevance of their sociality, with potential impact on our understanding of virulence and resistance in clinically and agriculturally important bacterial species.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry
- natural sciences biological sciences microbiology virology
- natural sciences biological sciences ecology
You need to log in or register to use this function
Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
-
HORIZON.1.1 - European Research Council (ERC)
MAIN PROGRAMME
See all projects funded under this programme
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-ERC-SYG - HORIZON ERC Synergy Grants
See all projects funded under this funding scheme
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) ERC-2023-SyG
See all projects funded under this callHost institution
Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
69978 Tel Aviv
Israel
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.