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Doctoral training network TAu imMunE: strategies for innovative diagnosis and therapies in dementia

Description du projet

Faire progresser la recherche sur la maladie d’Alzheimer pour un avenir plus sain

La maladie d’Alzheimer et ses équivalents liés à la protéine tau englobent un spectre de troubles neurodégénératifs caractérisés par une accumulation anormale de cette même protéine tau dans le cerveau. Ces pathologies tau comprennent des maladies telles que la paralysie supranucléaire progressive, la dégénérescence corticobasale et la démence fronto-+temporale, entre autres. Étant donné l’immense fardeau que ces pathologies font peser sur les individus, les familles et la société dans son ensemble, le besoin de diagnostics et de traitements efficaces se fait de plus en plus pressant. Dans ce contexte, le projet TAME, financé par le programme MSCA, réunit des experts universitaires et industriels de premier plan afin d’améliorer la compréhension des maladies liées à la protéine tau et de mettre au point des diagnostics et des interventions plus sûrs et personnalisés. Plus précisément, l’approche pluridisciplinaire du projet combine les neurosciences moléculaires, l’informatique, la chimie et la bio-ingénierie. En formant neuf scientifiques talentueux du vivant, le projet met l’accent sur la recherche, le développement personnel et la science ouverte.

Objectif

There is an urgent medical need for efficient diagnostics for Alzheimer’s disease and related tauopathies, as well as disease modifying treatments, due to the heavy burden of the disease on patients, families and society. To address this public health issue, TAME R&I training network gathers leading academic and industrial experts in tau research with the ambition to keep older people active and independent for longer. TAME aims to provide better understanding of tau-related diseases and supports the development of new, safer, personalised and more effective diagnosis and interventions for AD and the less common tauopathies. The beneficiaries and partners bring together resources and knowledge across different fields and technologies to provide a multidisciplinary approach necessary to take on the challenge. They have teamed-up to combine molecular and cellular neuroscience with computing, chemical and bio-engineering and their technology expertise. The first tau network of Europe, TAME, will focus on novel approaches using nanobodies, which have emerged as very promising antibody formats in tau research. The primary objective of the TAME is to train 9 fellows to deliver the next generation of talented life scientists. The program will be a combination of training in research, in personal and professional development and in open science, achieved by conducting research projects, attending courses and benefiting from internal mobility within TAME. The research training is based on cutting-edge technologies and advanced models for medical research, emphasizing the need for more human-based research, gender-personalised models and reduction in the use of animals. Consequently, through intense collaboration with all partners and the relevant industrial experience, these 9 fellows can anticipate improved career prospects and higher employability. TAME will provide an innovation-friendly framework in which scientific results can mature and be developed into products.

Coordinateur

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
Contribution nette de l'UE
€ 282 693,60
Adresse
RUE MICHEL ANGE 3
75794 Paris
France

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Région
Ile-de-France Ile-de-France Paris
Type d’activité
Research Organisations
Liens
Coût total
Aucune donnée

Participants (8)

Partenaires (13)