Project description
Cellular screening for cancer diagnosis, for everyone
Biomedical screening conducted at the single-cell and bioparticle levels has the potential to revolutionise clinical diagnostics. The MSCA-funded NEXTSCREEN project will train researchers, enabling them to create advanced screening methods. These methods involve the automated imaging and classification of samples within a liquid stream. The researchers’ objectives are to reduce the expenses and intricacies associated with imaging flow cytometry, construct automated microscopes with high resolution, and craft real-time data processing tools for the identification and recognition of samples. This will make it possible to screen extensive populations of blood cells and bioparticles, leading to the identification of cancer biomarkers in liquid biopsy samples. Ultimately, the project aims to democratise the usage of automatic screening.
Objective
Biomedical screening at single-cell and bioparticles level has the potential to transform clinical diagnostics, but the research and development in this field are scattered in different disciplines: biophotonics, micromanipulation, machine learning, in vitro diagnostics, and clinical regulations are traditionally imparted in separate training programs.
NEXTSCREEN aims to train and establish a network of researchers with the expertise required for the development of next-generation screening methods, based on automatic imaging and classification of samples moving along a liquid stream. The researchers have the objectives to reduce the cost and complexity of imaging flow cytometry; empower it with novel contrast mechanisms; build high-resolution automatic microscopes at the diffraction limit and beyond; develop real-time data processing tools able to detect and recognize the samples, circumventing the need for manual annotation. Using these technologies they will characterize blood cells and bioparticles, screening large cellular populations, with the goal to identify and characterize cancer biomarkers, in samples derived from liquid biopsies. The ultimate goal is to initiate the development of diagnostics tools, that could be adopted in clinical settings on a large scale, democratizing the use of automatic screening.
The project brings together academic and industrial research groups, that are leading the field of imaging flow cytometry, with complementary know-how in high-resolution microscopy, high-precision microfluidics, biotechnologies, and weakly-supervised deep learning, that will facilitate the development of data-driven cells and bioparticle screening.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- natural sciences physical sciences classical mechanics fluid mechanics microfluidics
- natural sciences physical sciences optics microscopy
- medical and health sciences clinical medicine oncology
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-DN - HORIZON TMA MSCA Doctoral Networks
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2022-DN-01
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
20133 Milano
Italy
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.