Global Amyloid Mapping: Solving Amyloid Nucleation by Deep Mutagenesis

Project Information

GLAM-Map

Grant agreement ID: 101125484

DOI

10.3030/101125484

EC signature date 14 February 2024

Start date 1 May 2024

End date 30 April 2029

Funded under

• European Research Council (ERC)

Total cost

€ 1 999 008,00

EU contribution

€ 1 999 008,00

Coordinated by

FUNDACIO INSTITUT DE BIOENGINYERIA DE CATALUNYA
Spain

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (6)

Massive mutagenesis reveals an incomplete amyloid motif in Bri2 that turns amyloidogenic upon C-terminal extension

Author(s): Mariano Martín, Benedetta Bolognesi
Published in: Proceedings of the National Academy of Sciences, Issue 122, 2025, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/PNAS.2415521122

Massive experimental quantification allows interpretable deep learning of protein aggregation

Author(s): Mike Thompson, Mariano Martín, Trinidad Sanmartín Olmo, Chandana Rajesh, Peter K. Koo, Benedetta Bolognesi, Ben Lehner
Published in: Science Advances, Issue 11, 2025, ISSN 2375-2548
Publisher: American Association for the Advancement of Science (AAAS)
DOI: 10.1126/SCIADV.ADT5111

An atlas of amyloid aggregation: the impact of substitutions, insertions, deletions and truncations on amyloid beta fibril nucleation

Author(s): Mireia Seuma, Ben Lehner, Benedetta Bolognesi
Published in: Nature Communications, Issue 13, 2022, ISSN 2041-1723
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/S41467-022-34742-3

Minimum information and guidelines for reporting a multiplexed assay of variant effect

Author(s): Melina Claussnitzer, Victoria N. Parikh, Alex H. Wagner, Jeremy A. Arbesfeld, Carol J. Bult, Helen V. Firth, Lara A. Muffley, Alex N. Nguyen Ba, Kevin Riehle, Frederick P. Roth, Daniel Tabet, Benedetta Bolognesi, Andrew M. Glazer, Alan F. Rubin
Published in: Genome Biology, Issue 25, 2024, ISSN 1474-760X
Publisher: Springer Science and Business Media LLC
DOI: 10.1186/S13059-024-03223-9

Massively parallel quantification of mutational impact on IAPP amyloid formation

Author(s): Marta Badia, Cristina Batlle, Benedetta Bolognesi
Published in: Nature Communications, Issue 17, 2026, ISSN 2041-1723
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/S41467-026-70611-Z

Massively parallel genetic perturbation suggests the energetic structure of an amyloid-β transition state

Author(s): Anna Arutyunyan, Mireia Seuma, Andre J. Faure, Benedetta Bolognesi, Ben Lehner
Published in: Science Advances, Issue 11, 2025, ISSN 2375-2548
Publisher: American Association for the Advancement of Science (AAAS)
DOI: 10.1126/SCIADV.ADV1422