Massive mutagenesis reveals an incomplete amyloid motif in Bri2 that turns amyloidogenic upon C-terminal extension
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Autores:
Mariano Martín, Benedetta Bolognesi
Publicado en:
Proceedings of the National Academy of Sciences, Edición 122, 2025, ISSN 0027-8424
Editor:
National Academy of Sciences
DOI:
10.1073/PNAS.2415521122
Massive experimental quantification allows interpretable deep learning of protein aggregation
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Autores:
Mike Thompson, Mariano Martín, Trinidad Sanmartín Olmo, Chandana Rajesh, Peter K. Koo, Benedetta Bolognesi, Ben Lehner
Publicado en:
Science Advances, Edición 11, 2025, ISSN 2375-2548
Editor:
American Association for the Advancement of Science (AAAS)
DOI:
10.1126/SCIADV.ADT5111
An atlas of amyloid aggregation: the impact of substitutions, insertions, deletions and truncations on amyloid beta fibril nucleation
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Autores:
Mireia Seuma, Ben Lehner, Benedetta Bolognesi
Publicado en:
Nature Communications, Edición 13, 2022, ISSN 2041-1723
Editor:
Springer Science and Business Media LLC
DOI:
10.1038/S41467-022-34742-3
Minimum information and guidelines for reporting a multiplexed assay of variant effect
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Autores:
Melina Claussnitzer, Victoria N. Parikh, Alex H. Wagner, Jeremy A. Arbesfeld, Carol J. Bult, Helen V. Firth, Lara A. Muffley, Alex N. Nguyen Ba, Kevin Riehle, Frederick P. Roth, Daniel Tabet, Benedetta Bolognesi, Andrew M. Glazer, Alan F. Rubin
Publicado en:
Genome Biology, Edición 25, 2024, ISSN 1474-760X
Editor:
Springer Science and Business Media LLC
DOI:
10.1186/S13059-024-03223-9
Massively parallel quantification of mutational impact on IAPP amyloid formation
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Autores:
Marta Badia, Cristina Batlle, Benedetta Bolognesi
Publicado en:
Nature Communications, Edición 17, 2026, ISSN 2041-1723
Editor:
Springer Science and Business Media LLC
DOI:
10.1038/S41467-026-70611-Z
Massively parallel genetic perturbation suggests the energetic structure of an amyloid-β transition state
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Autores:
Anna Arutyunyan, Mireia Seuma, Andre J. Faure, Benedetta Bolognesi, Ben Lehner
Publicado en:
Science Advances, Edición 11, 2025, ISSN 2375-2548
Editor:
American Association for the Advancement of Science (AAAS)
DOI:
10.1126/SCIADV.ADV1422
