Project description
Paving the way for innovative advancements in adenovirus biology
Adenovirus-based vectors hold promise for gene transfer and vaccination, offering potential translational and commercial value. However, their efficacy is contingent upon low seroprevalence strains, which are crucial for vector design. Yet, understanding these strains thoroughly remains a challenge, hindering their application in therapeutic contexts. With the support of the Marie Skłodowska-Curie Actions programme, the INVECTA project fosters collaborative research on novel low seroprevalence adenovirus vectors. Its mission encompasses understanding vector-host interactions, tropism, and immune responses. With a focus on training researchers and establishing long-term collaboration, INVECTA aims to advance cancer gene therapy and vaccination. Through interdisciplinary efforts and knowledge sharing, the project seeks to define protocols and methodologies for safe and effective adenoviral applications.
Objective
Adenovirus based vectors have potential translational and commercial values and are studied as vectors for gene transfer and vaccination . Low seroprevalence adenoviruses are efficacious platforms for vector design, warranting their thorough investigation. Therefore, the main objective of INVECTA is to establish a collaborative effort for the study of scientific problems related to development of novel low seroprevalence adenovirus based vectors aimed at their therapeutic usage, with an emphasis on training both experienced and early stage researchers in adenovirus research, as well as establishing foundation for long term collaboration. As the use of adenoviral based platforms becomes widespread there is a pressing need to develop protocols and methodologies to define the full complement of adenovirus-host interactions, the “adenoviral interactome”, that may limit efficacy and compromise safety. Within INVECTA we aim to increase our understanding of novel low seroprevalence adenovirus vectors with respect to infectivity, structure, stability, receptor usage, tropism, and the interaction with the blood and immune system. This knowledge will allow us to evaluate novel low seroprevalence vectors at the pre-clinical level in areas of unmet clinical need, namely cancer gene therapy and vaccination. INVECTA presents an interdisciplinary and intersectoral network in basic and translational adenovirus research which will foster transfer of knowledge, skills and technology, as well as enable training in the field of basic and applicative adenovirus biology. To maximize knowledge sharing, INVECTA will second researchers within consortium, organize internal workshops and training sessions, and strongly encourage participation in specialized workshops, schools and conferences according to the open science model.
Fields of science
Programme(s)
- HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA) Main Programme
Funding Scheme
HORIZON-TMA-MSCA-SE - HORIZON TMA MSCA Staff ExchangesCoordinator
10000 Zagreb
Croatia