Descripción del proyecto
Preparar el camino para avances innovadores en la biología de los adenovirus
Los vectores basados en adenovirus son prometedores para la transferencia de genes y la vacunación, y ofrecen un potencial valor traslacional y comercial. Sin embargo, su eficacia depende de cepas de baja seroprevalencia, que son cruciales para el diseño del vector. No obstante, comprender en detalle estas cepas sigue siendo un reto, lo que dificulta su aplicación en contextos terapéuticos. El equipo del proyecto INVECTA, que cuenta con el apoyo de las Acciones Marie Skłodowska-Curie, fomenta la investigación colaborativa sobre nuevos vectores de adenovirus de baja seroprevalencia. Su misión abarca la comprensión de las interacciones entre el vector y el hospedador, el tropismo y las respuestas inmunitarias. Centrado en la formación de investigadores y el establecimiento de colaboraciones a largo plazo, en INVECTA se pretende avanzar en la terapia génica y la vacunación contra el cáncer. Mediante esfuerzos interdisciplinarios y el intercambio de conocimientos, el equipo del proyecto pretende definir protocolos y metodologías para aplicaciones adenovíricas seguras y eficaces.
Objetivo
Adenovirus based vectors have potential translational and commercial values and are studied as vectors for gene transfer and vaccination . Low seroprevalence adenoviruses are efficacious platforms for vector design, warranting their thorough investigation. Therefore, the main objective of INVECTA is to establish a collaborative effort for the study of scientific problems related to development of novel low seroprevalence adenovirus based vectors aimed at their therapeutic usage, with an emphasis on training both experienced and early stage researchers in adenovirus research, as well as establishing foundation for long term collaboration. As the use of adenoviral based platforms becomes widespread there is a pressing need to develop protocols and methodologies to define the full complement of adenovirus-host interactions, the “adenoviral interactome”, that may limit efficacy and compromise safety. Within INVECTA we aim to increase our understanding of novel low seroprevalence adenovirus vectors with respect to infectivity, structure, stability, receptor usage, tropism, and the interaction with the blood and immune system. This knowledge will allow us to evaluate novel low seroprevalence vectors at the pre-clinical level in areas of unmet clinical need, namely cancer gene therapy and vaccination. INVECTA presents an interdisciplinary and intersectoral network in basic and translational adenovirus research which will foster transfer of knowledge, skills and technology, as well as enable training in the field of basic and applicative adenovirus biology. To maximize knowledge sharing, INVECTA will second researchers within consortium, organize internal workshops and training sessions, and strongly encourage participation in specialized workshops, schools and conferences according to the open science model.
Ámbito científico
Palabras clave
Programa(s)
- HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA) Main Programme
Régimen de financiación
HORIZON-TMA-MSCA-SE - HORIZON TMA MSCA Staff ExchangesCoordinador
10000 Zagreb
Croacia