Project description
Personalised brain health assessment for Alzheimer’s
Tracking the progression of neurodegenerative diseases like Alzheimer's disease (AD) is crucial for enabling targeted interventions that can enhance quality of life. Mechanistic modelling approaches can help with capturing the inter-individual variability and guiding the personalised treatments. The challenge lies in identifying relevant parameters, for which the utility of spontaneous brain activity is limited. Without precise tracking, the opportunity for timely interventions diminishes, impacting both patients and healthcare systems. The EU-funded PINGED project will use non-invasive brain stimulation techniques, specifically temporal interference, to determine whether responses to stimulation can accurately reflect an individual's position along the AD progression trajectory. By integrating targeted stimulation data with resting-state dynamics from fMRI, PINGED aims to develop a personalised brain health status estimation workflow.
Objective
Tracking of individual progression trajectory of neurodegenerative brain disease such as Alzheimer's disease (AD) can enable targeted interventions to prolong active living with increased quality of life and substantially reduce the socioeconomic burden. Approaches based on mechanistic modeling have the capacity to integrate heterogeneous data and capture the inter-individual variability, but their application in the case of AD is challenging due to non-idetifiability of relevant parameters from spontaneous brain activity. This project will use the recently developed technology for noninvasive brain stimulation - the temporal interference - to address the key question: is the response to stimulation sufficiently informative to allow estimation of the model parameters reflecting the position of an individual along the AD progression trajectory. The main objective of this project is to develop and validate a proof-of-concept of a brain health status estimation workflow informed by both the response to targeted non-invasive stimulation (TI) and the resting state dynamics (fMRI), while leveraging the personalized model-based inference. The project will advance along following main axes: systematic analysis of parameter identifiability using both stimulation and resting state paradigms, development of a personalization workflow combining structural data, resting state fMRI and the TI, and evaluation of model inversion performance using response to different stimulation targets. The results of the project have the potential to pioneer personalized mechanistic model inversion in the context of AD, and to pave the way for further development of the AD monitoring workflows which can be adapted in routine health screening practices.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.4.1 - Widening participation and spreading excellence
MAIN PROGRAMME
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HORIZON.4.1.5 - Fostering brain circulation of researchers and excellence initiatives
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-WIDERA-2022-TALENTS-04
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
601 77 Brno
Czechia
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.