Human ECM-based platform for anti-cancer drug testing - CARES (CAncer dRug tESting)

Project Information

CARES

Grant agreement ID: 101130985

DOI

10.3030/101130985

EC signature date 3 July 2023

Start date 1 November 2023

End date 31 October 2027

Funded under

• Marie Skłodowska-Curie Actions (MSCA)

Total cost

No data

EU contribution

€ 276 000,00

Coordinated by

ASOCIACION CENTRO DE INVESTIGACION COOPERATIVA EN BIOCIENCIAS
Spain

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Data Management Plan (2)

Data Management Plan – Version 1
Data Management Plan – Version 2

Websites, patent fillings, videos etc. (1)

Website and societal media implemented

Publications

Peer reviewed articles (17)

Spheroid-Based 3D Models to Decode Cell Function and Matrix Effectors in Breast Cancer

Author(s): Sylvia Mangani, Christos Koutsakis, Nikolaos E. Koletsis, Zoi Piperigkou, Marco Franchi, Martin Götte, Nikos K. Karamanos
Published in: Cancers, Issue 17, 2025, ISSN 2072-6694
Publisher: MDPI AG
DOI: 10.3390/CANCERS17213512

Ultrastructural Changes of the Peri-Tumoral Collagen Fibers and Fibrils Array in Different Stages of Mammary Cancer Progression

Author(s): Marco Franchi, Valentina Masola, Maurizio Onisto, Leonardo Franchi, Sylvia Mangani, Vasiliki Zolota, Zoi Piperigkou, Nikos K. Karamanos
Published in: Cells, Issue 14, 2025, ISSN 2073-4409
Publisher: MDPI AG
DOI: 10.3390/CELLS14131037

Principal mechanisms of extracellular matrix‐mediated cell–cell communication in physiological and tumor microenvironments

Author(s): Zoi Piperigkou, Sylvia Mangani, Nikolaos E. Koletsis, Christos Koutsakis, Nicholas S. Mastronikolis, Marco Franchi, Nikos K. Karamanos
Published in: The FEBS Journal, 2025, ISSN 1742-464X
Publisher: Wiley
DOI: 10.1111/FEBS.70207

From Structure to Function: The Impact of EGFR and IGF-IR in 3D Breast Cancer Spheroids

Author(s): Chrisavgi Gourdoupi, Spyros Kremmydas, Sylvia Mangani, Paraskevi Ioannou, Nikolaos A. Afratis, Zoi Piperigkou, Nikos K. Karamanos
Published in: Cancers, Issue 17, 2025, ISSN 2072-6694
Publisher: MDPI AG
DOI: 10.3390/CANCERS17162606

A guide to the types, structures, and multifaceted functions of matrix metalloproteinases in cancer

Author(s): Zoi Piperigkou, Sylvia Mangani, Spyros Kremmydas, Nikolaos E. Koletsis, Nikos K. Karamanos
Published in: The FEBS Journal, 2025, ISSN 1742-464X
Publisher: Wiley
DOI: 10.1111/FEBS.70296

Deciphering Drug Resistance: Investigating the Emerging Role of Hyaluronan Metabolism and Signaling and Tumor Extracellular Matrix in Cancer Chemotherapy

Author(s): Vitale, Parnigoni, Viola, Karousou, Sevic, Moretto, A PASSI, L ALANIZ, D Vigetti
Published in: Int. J. Mol. Sci., Issue 14, 2024
Publisher: mdpi
DOI: 10.3390/ijms25147607

Design and Applications of Extracellular Matrix Scaffolds in Tissue Engineering and Regeneration

Author(s): Sylvia Mangani, Marios Vetoulas, Katerina Mineschou, Konstantinos Spanopoulos, Maria dM. Vivanco, Zoi Piperigkou, Nikos K. Karamanos
Published in: Cells, Issue 14, 2025, ISSN 2073-4409
Publisher: MDPI AG
DOI: 10.3390/CELLS14141076

Development, Functional Characterization, and Matrix Effectors Dynamics in 3D Spheroids of Triple-Negative Breast Cancer Cells

Author(s): Nikolaos E. Koletsis, Sylvia Mangani, Marco Franchi, Zoi Piperigkou, Nikos K. Karamanos
Published in: Cells, Issue 14, 2025, ISSN 2073-4409
Publisher: MDPI AG
DOI: 10.3390/CELLS14171351

SELF-ASSEMBLED PEPTIDE RADA16 HYDROGEL PROMOTES EPITHELIALIZATION OF WOUNDS BY A LAMININ-332-DEPENDENT SCAVENGING MECHANISM

Author(s): Chloé Laigle, Marie Buffier, Emélie Clémens, Sharanya Sankar, Patricia Rousselle
Published in: Acta Biomaterialia, 2025, ISSN 1742-7061
Publisher: Elsevier BV
DOI: 10.1016/J.ACTBIO.2025.09.055

Targeting EGFR/IGF-IR Functional Crosstalk in 2D and 3D Triple-Negative Breast Cancer Models to Evaluate Tumor Progression

Author(s): Spyros Kremmydas, Chrisavgi Gourdoupi, Zoi Piperigkou, Nikos K. Karamanos
Published in: International Journal of Molecular Sciences, Issue 26, 2025, ISSN 1422-0067
Publisher: MDPI AG
DOI: 10.3390/IJMS26178665

Bioderived Green Algae Metabolite as a Latent Cross-Linking Agent for Protein-Based Hydrogels with High Potential for Skin Repair Applications

Author(s): Giuseppe Melilli, Patricia Rousselle, Mohamed Mehiri, Nathanael Guigo, Didier Pin, Nicolas Sbirrazzuoli
Published in: ACS Applied Bio Materials, Issue 8, 2025, ISSN 2576-6422
Publisher: American Chemical Society (ACS)
DOI: 10.1021/ACSABM.5C00010

Nanoparticles and Glycosaminoglycans: Progress andApplications for Cancer Therapy

Author(s): Pietro Milesi, Annamaria Naggi, Francesca Baldelli Bombelli, Martin Götte, Jessica Oyie Sousa Onyeisi
Published in: Proteoglycan Research, Issue 3, 2025, ISSN 2832-3556
Publisher: Wiley
DOI: 10.1002/PGR2.70024

Alteration of Hyaluronic Acid Metabolism in Tumor Microenvironment Can Modulate DNA Repair Gene Expression: Therapeutic Potential for Triple-Negative Breast Cancer

Author(s): Ina Sevic, Daiana Lujan Vitale, Candela Moran Maidana, Paolo Rosales, Antonella Icardi, Catalina Latina, Lucia Romano, Alejandra Brandone, Paula Giannoni, Laura Alaniz
Published in: International Journal of Molecular Sciences, Issue 26, 2025, ISSN 1422-0067
Publisher: MDPI AG
DOI: 10.3390/IJMS262311328

Estrogen receptors and extracellular matrix: the critical interplay in cancer development and progression

Author(s): Sylvia Mangani, Zoi Piperigkou, Nikolaos E. Koletsis, Paraskevi Ioannou, Nikos K. Karamanos
Published in: The FEBS Journal, Issue 292, 2025, ISSN 1742-464X
Publisher: Wiley
DOI: 10.1111/FEBS.17270

MatriCom, a single-cell RNA-sequencing data mining tool to infer cell–extracellular matrix interactions

Author(s): Rijuta Lamba, Asia M. Paguntalan, Petar B. Petrov, Alexandra Naba, Valerio Izzi
Published in: Journal of Cell Science, Issue 138, 2025, ISSN 0021-9533
Publisher: The Company of Biologists
DOI: 10.1242/JCS.263927

4‐Methylumbelliferone Sensitizes Breast Cancer Spheroids to Chemotherapeutic Treatment With Epirubicin: New Perspectives for Pharmacological Repositioning

Author(s): Daiana Luján Vitale, Antonella Icardi, Paolo Rosales, Candela Morán, Ina Sevic, Laura Daniela Alaniz
Published in: IUBMB Life, Issue 77, 2025, ISSN 1521-6543
Publisher: Wiley
DOI: 10.1002/IUB.70075

Extracellular matrix matters: matrix-based bioscaffolds in advancing translational cancer research and targeted therapy

Author(s): Nikos K. Karamanos, Zoi Piperigkou, Chrisavgi Gourdoupi, Sylvia Mangani, Maria dM. Vivanco
Published in: American Journal of Physiology-Cell Physiology, Issue 328, 2025, ISSN 0363-6143
Publisher: American Physiological Society
DOI: 10.1152/AJPCELL.00050.2025