Human ECM-based platform for anti-cancer drug testing - CARES (CAncer dRug tESting)

Informazioni relative al progetto

CARES

ID dell’accordo di sovvenzione: 101130985

DOI

10.3030/101130985

Data della firma CE 3 Luglio 2023

Data di avvio 1 Novembre 2023

Data di completamento 31 Ottobre 2027

Finanziato da

• Marie Skłodowska-Curie Actions (MSCA)

Costo totale

Nessun dato

Contributo UE

€ 276 000,00

Coordinato da

ASOCIACION CENTRO DE INVESTIGACION COOPERATIVA EN BIOCIENCIAS
Spain

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Data Management Plan (2)

Data Management Plan – Version 1
Data Management Plan – Version 2

Websites, patent fillings, videos etc. (1)

Website and societal media implemented

Pubblicazioni

Peer reviewed articles (17)

Spheroid-Based 3D Models to Decode Cell Function and Matrix Effectors in Breast Cancer

Autori: Sylvia Mangani, Christos Koutsakis, Nikolaos E. Koletsis, Zoi Piperigkou, Marco Franchi, Martin Götte, Nikos K. Karamanos
Pubblicato in: Cancers, Numero 17, 2025, ISSN 2072-6694
Editore: MDPI AG
DOI: 10.3390/CANCERS17213512

Ultrastructural Changes of the Peri-Tumoral Collagen Fibers and Fibrils Array in Different Stages of Mammary Cancer Progression

Autori: Marco Franchi, Valentina Masola, Maurizio Onisto, Leonardo Franchi, Sylvia Mangani, Vasiliki Zolota, Zoi Piperigkou, Nikos K. Karamanos
Pubblicato in: Cells, Numero 14, 2025, ISSN 2073-4409
Editore: MDPI AG
DOI: 10.3390/CELLS14131037

Principal mechanisms of extracellular matrix‐mediated cell–cell communication in physiological and tumor microenvironments

Autori: Zoi Piperigkou, Sylvia Mangani, Nikolaos E. Koletsis, Christos Koutsakis, Nicholas S. Mastronikolis, Marco Franchi, Nikos K. Karamanos
Pubblicato in: The FEBS Journal, 2025, ISSN 1742-464X
Editore: Wiley
DOI: 10.1111/FEBS.70207

From Structure to Function: The Impact of EGFR and IGF-IR in 3D Breast Cancer Spheroids

Autori: Chrisavgi Gourdoupi, Spyros Kremmydas, Sylvia Mangani, Paraskevi Ioannou, Nikolaos A. Afratis, Zoi Piperigkou, Nikos K. Karamanos
Pubblicato in: Cancers, Numero 17, 2025, ISSN 2072-6694
Editore: MDPI AG
DOI: 10.3390/CANCERS17162606

A guide to the types, structures, and multifaceted functions of matrix metalloproteinases in cancer

Autori: Zoi Piperigkou, Sylvia Mangani, Spyros Kremmydas, Nikolaos E. Koletsis, Nikos K. Karamanos
Pubblicato in: The FEBS Journal, 2025, ISSN 1742-464X
Editore: Wiley
DOI: 10.1111/FEBS.70296

Deciphering Drug Resistance: Investigating the Emerging Role of Hyaluronan Metabolism and Signaling and Tumor Extracellular Matrix in Cancer Chemotherapy

Autori: Vitale, Parnigoni, Viola, Karousou, Sevic, Moretto, A PASSI, L ALANIZ, D Vigetti
Pubblicato in: Int. J. Mol. Sci., Numero 14, 2024
Editore: mdpi
DOI: 10.3390/ijms25147607

Design and Applications of Extracellular Matrix Scaffolds in Tissue Engineering and Regeneration

Autori: Sylvia Mangani, Marios Vetoulas, Katerina Mineschou, Konstantinos Spanopoulos, Maria dM. Vivanco, Zoi Piperigkou, Nikos K. Karamanos
Pubblicato in: Cells, Numero 14, 2025, ISSN 2073-4409
Editore: MDPI AG
DOI: 10.3390/CELLS14141076

Development, Functional Characterization, and Matrix Effectors Dynamics in 3D Spheroids of Triple-Negative Breast Cancer Cells

Autori: Nikolaos E. Koletsis, Sylvia Mangani, Marco Franchi, Zoi Piperigkou, Nikos K. Karamanos
Pubblicato in: Cells, Numero 14, 2025, ISSN 2073-4409
Editore: MDPI AG
DOI: 10.3390/CELLS14171351

SELF-ASSEMBLED PEPTIDE RADA16 HYDROGEL PROMOTES EPITHELIALIZATION OF WOUNDS BY A LAMININ-332-DEPENDENT SCAVENGING MECHANISM

Autori: Chloé Laigle, Marie Buffier, Emélie Clémens, Sharanya Sankar, Patricia Rousselle
Pubblicato in: Acta Biomaterialia, 2025, ISSN 1742-7061
Editore: Elsevier BV
DOI: 10.1016/J.ACTBIO.2025.09.055

Targeting EGFR/IGF-IR Functional Crosstalk in 2D and 3D Triple-Negative Breast Cancer Models to Evaluate Tumor Progression

Autori: Spyros Kremmydas, Chrisavgi Gourdoupi, Zoi Piperigkou, Nikos K. Karamanos
Pubblicato in: International Journal of Molecular Sciences, Numero 26, 2025, ISSN 1422-0067
Editore: MDPI AG
DOI: 10.3390/IJMS26178665

Bioderived Green Algae Metabolite as a Latent Cross-Linking Agent for Protein-Based Hydrogels with High Potential for Skin Repair Applications

Autori: Giuseppe Melilli, Patricia Rousselle, Mohamed Mehiri, Nathanael Guigo, Didier Pin, Nicolas Sbirrazzuoli
Pubblicato in: ACS Applied Bio Materials, Numero 8, 2025, ISSN 2576-6422
Editore: American Chemical Society (ACS)
DOI: 10.1021/ACSABM.5C00010

Nanoparticles and Glycosaminoglycans: Progress andApplications for Cancer Therapy

Autori: Pietro Milesi, Annamaria Naggi, Francesca Baldelli Bombelli, Martin Götte, Jessica Oyie Sousa Onyeisi
Pubblicato in: Proteoglycan Research, Numero 3, 2025, ISSN 2832-3556
Editore: Wiley
DOI: 10.1002/PGR2.70024

Alteration of Hyaluronic Acid Metabolism in Tumor Microenvironment Can Modulate DNA Repair Gene Expression: Therapeutic Potential for Triple-Negative Breast Cancer

Autori: Ina Sevic, Daiana Lujan Vitale, Candela Moran Maidana, Paolo Rosales, Antonella Icardi, Catalina Latina, Lucia Romano, Alejandra Brandone, Paula Giannoni, Laura Alaniz
Pubblicato in: International Journal of Molecular Sciences, Numero 26, 2025, ISSN 1422-0067
Editore: MDPI AG
DOI: 10.3390/IJMS262311328

Estrogen receptors and extracellular matrix: the critical interplay in cancer development and progression

Autori: Sylvia Mangani, Zoi Piperigkou, Nikolaos E. Koletsis, Paraskevi Ioannou, Nikos K. Karamanos
Pubblicato in: The FEBS Journal, Numero 292, 2025, ISSN 1742-464X
Editore: Wiley
DOI: 10.1111/FEBS.17270

MatriCom, a single-cell RNA-sequencing data mining tool to infer cell–extracellular matrix interactions

Autori: Rijuta Lamba, Asia M. Paguntalan, Petar B. Petrov, Alexandra Naba, Valerio Izzi
Pubblicato in: Journal of Cell Science, Numero 138, 2025, ISSN 0021-9533
Editore: The Company of Biologists
DOI: 10.1242/JCS.263927

4‐Methylumbelliferone Sensitizes Breast Cancer Spheroids to Chemotherapeutic Treatment With Epirubicin: New Perspectives for Pharmacological Repositioning

Autori: Daiana Luján Vitale, Antonella Icardi, Paolo Rosales, Candela Morán, Ina Sevic, Laura Daniela Alaniz
Pubblicato in: IUBMB Life, Numero 77, 2025, ISSN 1521-6543
Editore: Wiley
DOI: 10.1002/IUB.70075

Extracellular matrix matters: matrix-based bioscaffolds in advancing translational cancer research and targeted therapy

Autori: Nikos K. Karamanos, Zoi Piperigkou, Chrisavgi Gourdoupi, Sylvia Mangani, Maria dM. Vivanco
Pubblicato in: American Journal of Physiology-Cell Physiology, Numero 328, 2025, ISSN 0363-6143
Editore: American Physiological Society
DOI: 10.1152/AJPCELL.00050.2025