Human ECM-based platform for anti-cancer drug testing - CARES (CAncer dRug tESting)

Información del proyecto

CARES

Identificador del acuerdo de subvención: 101130985

DOI

10.3030/101130985

Fecha de la firma de la CE 3 Julio 2023

Fecha de inicio 1 Noviembre 2023

Fecha de finalización 31 Octubre 2027

Financiado con arreglo a

• Marie Skłodowska-Curie Actions (MSCA)

Coste total

Sin datos

Aportación de la UE

€ 276 000,00

Coordinado por

ASOCIACION CENTRO DE INVESTIGACION COOPERATIVA EN BIOCIENCIAS
Spain

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Data Management Plan (2)

Data Management Plan – Version 1
Data Management Plan – Version 2

Websites, patent fillings, videos etc. (1)

Website and societal media implemented

Publicaciones

Peer reviewed articles (17)

Spheroid-Based 3D Models to Decode Cell Function and Matrix Effectors in Breast Cancer

Autores: Sylvia Mangani, Christos Koutsakis, Nikolaos E. Koletsis, Zoi Piperigkou, Marco Franchi, Martin Götte, Nikos K. Karamanos
Publicado en: Cancers, Edición 17, 2025, ISSN 2072-6694
Editor: MDPI AG
DOI: 10.3390/CANCERS17213512

Ultrastructural Changes of the Peri-Tumoral Collagen Fibers and Fibrils Array in Different Stages of Mammary Cancer Progression

Autores: Marco Franchi, Valentina Masola, Maurizio Onisto, Leonardo Franchi, Sylvia Mangani, Vasiliki Zolota, Zoi Piperigkou, Nikos K. Karamanos
Publicado en: Cells, Edición 14, 2025, ISSN 2073-4409
Editor: MDPI AG
DOI: 10.3390/CELLS14131037

Principal mechanisms of extracellular matrix‐mediated cell–cell communication in physiological and tumor microenvironments

Autores: Zoi Piperigkou, Sylvia Mangani, Nikolaos E. Koletsis, Christos Koutsakis, Nicholas S. Mastronikolis, Marco Franchi, Nikos K. Karamanos
Publicado en: The FEBS Journal, 2025, ISSN 1742-464X
Editor: Wiley
DOI: 10.1111/FEBS.70207

From Structure to Function: The Impact of EGFR and IGF-IR in 3D Breast Cancer Spheroids

Autores: Chrisavgi Gourdoupi, Spyros Kremmydas, Sylvia Mangani, Paraskevi Ioannou, Nikolaos A. Afratis, Zoi Piperigkou, Nikos K. Karamanos
Publicado en: Cancers, Edición 17, 2025, ISSN 2072-6694
Editor: MDPI AG
DOI: 10.3390/CANCERS17162606

A guide to the types, structures, and multifaceted functions of matrix metalloproteinases in cancer

Autores: Zoi Piperigkou, Sylvia Mangani, Spyros Kremmydas, Nikolaos E. Koletsis, Nikos K. Karamanos
Publicado en: The FEBS Journal, 2025, ISSN 1742-464X
Editor: Wiley
DOI: 10.1111/FEBS.70296

Deciphering Drug Resistance: Investigating the Emerging Role of Hyaluronan Metabolism and Signaling and Tumor Extracellular Matrix in Cancer Chemotherapy

Autores: Vitale, Parnigoni, Viola, Karousou, Sevic, Moretto, A PASSI, L ALANIZ, D Vigetti
Publicado en: Int. J. Mol. Sci., Edición 14, 2024
Editor: mdpi
DOI: 10.3390/ijms25147607

Design and Applications of Extracellular Matrix Scaffolds in Tissue Engineering and Regeneration

Autores: Sylvia Mangani, Marios Vetoulas, Katerina Mineschou, Konstantinos Spanopoulos, Maria dM. Vivanco, Zoi Piperigkou, Nikos K. Karamanos
Publicado en: Cells, Edición 14, 2025, ISSN 2073-4409
Editor: MDPI AG
DOI: 10.3390/CELLS14141076

Development, Functional Characterization, and Matrix Effectors Dynamics in 3D Spheroids of Triple-Negative Breast Cancer Cells

Autores: Nikolaos E. Koletsis, Sylvia Mangani, Marco Franchi, Zoi Piperigkou, Nikos K. Karamanos
Publicado en: Cells, Edición 14, 2025, ISSN 2073-4409
Editor: MDPI AG
DOI: 10.3390/CELLS14171351

SELF-ASSEMBLED PEPTIDE RADA16 HYDROGEL PROMOTES EPITHELIALIZATION OF WOUNDS BY A LAMININ-332-DEPENDENT SCAVENGING MECHANISM

Autores: Chloé Laigle, Marie Buffier, Emélie Clémens, Sharanya Sankar, Patricia Rousselle
Publicado en: Acta Biomaterialia, 2025, ISSN 1742-7061
Editor: Elsevier BV
DOI: 10.1016/J.ACTBIO.2025.09.055

Targeting EGFR/IGF-IR Functional Crosstalk in 2D and 3D Triple-Negative Breast Cancer Models to Evaluate Tumor Progression

Autores: Spyros Kremmydas, Chrisavgi Gourdoupi, Zoi Piperigkou, Nikos K. Karamanos
Publicado en: International Journal of Molecular Sciences, Edición 26, 2025, ISSN 1422-0067
Editor: MDPI AG
DOI: 10.3390/IJMS26178665

Bioderived Green Algae Metabolite as a Latent Cross-Linking Agent for Protein-Based Hydrogels with High Potential for Skin Repair Applications

Autores: Giuseppe Melilli, Patricia Rousselle, Mohamed Mehiri, Nathanael Guigo, Didier Pin, Nicolas Sbirrazzuoli
Publicado en: ACS Applied Bio Materials, Edición 8, 2025, ISSN 2576-6422
Editor: American Chemical Society (ACS)
DOI: 10.1021/ACSABM.5C00010

Nanoparticles and Glycosaminoglycans: Progress andApplications for Cancer Therapy

Autores: Pietro Milesi, Annamaria Naggi, Francesca Baldelli Bombelli, Martin Götte, Jessica Oyie Sousa Onyeisi
Publicado en: Proteoglycan Research, Edición 3, 2025, ISSN 2832-3556
Editor: Wiley
DOI: 10.1002/PGR2.70024

Alteration of Hyaluronic Acid Metabolism in Tumor Microenvironment Can Modulate DNA Repair Gene Expression: Therapeutic Potential for Triple-Negative Breast Cancer

Autores: Ina Sevic, Daiana Lujan Vitale, Candela Moran Maidana, Paolo Rosales, Antonella Icardi, Catalina Latina, Lucia Romano, Alejandra Brandone, Paula Giannoni, Laura Alaniz
Publicado en: International Journal of Molecular Sciences, Edición 26, 2025, ISSN 1422-0067
Editor: MDPI AG
DOI: 10.3390/IJMS262311328

Estrogen receptors and extracellular matrix: the critical interplay in cancer development and progression

Autores: Sylvia Mangani, Zoi Piperigkou, Nikolaos E. Koletsis, Paraskevi Ioannou, Nikos K. Karamanos
Publicado en: The FEBS Journal, Edición 292, 2025, ISSN 1742-464X
Editor: Wiley
DOI: 10.1111/FEBS.17270

MatriCom, a single-cell RNA-sequencing data mining tool to infer cell–extracellular matrix interactions

Autores: Rijuta Lamba, Asia M. Paguntalan, Petar B. Petrov, Alexandra Naba, Valerio Izzi
Publicado en: Journal of Cell Science, Edición 138, 2025, ISSN 0021-9533
Editor: The Company of Biologists
DOI: 10.1242/JCS.263927

4‐Methylumbelliferone Sensitizes Breast Cancer Spheroids to Chemotherapeutic Treatment With Epirubicin: New Perspectives for Pharmacological Repositioning

Autores: Daiana Luján Vitale, Antonella Icardi, Paolo Rosales, Candela Morán, Ina Sevic, Laura Daniela Alaniz
Publicado en: IUBMB Life, Edición 77, 2025, ISSN 1521-6543
Editor: Wiley
DOI: 10.1002/IUB.70075

Extracellular matrix matters: matrix-based bioscaffolds in advancing translational cancer research and targeted therapy

Autores: Nikos K. Karamanos, Zoi Piperigkou, Chrisavgi Gourdoupi, Sylvia Mangani, Maria dM. Vivanco
Publicado en: American Journal of Physiology-Cell Physiology, Edición 328, 2025, ISSN 0363-6143
Editor: American Physiological Society
DOI: 10.1152/AJPCELL.00050.2025