Project description
A greener and healthier future for both plant and human well-being
Agriculture’s sustainability challenges are reaching critical levels, calling for innovative eco-friendly solutions. Extracellular vesicles, tiny structures released by living cells, have long been known for their pivotal roles in cellular communication. Now, researchers are exploring plant-derived vesicles as a game-changing alternative to those from mammalian cells. With the support of Marie Skłodowska-Curie Actions, the FarmEVs project will harness plant-derived vesicles to revolutionise sustainable agriculture, creating a greener, healthier future for all. It will establish a large-scale, vegetable-based system for vesicle production by harnessing organically grown crops. These plant-derived vesicles are set to revolutionise sustainable agriculture, thanks to the collaborative efforts of an international consortium comprising eight partners from six countries.
Objective
Extracellular vesicles (EVs) are biomembrane-enclosed structures that are ubiquitously secreted by living cells. EVs, by transferring proteins, lipids, nucleic acids and other molecules to neighbouring or distant cells contribute to tissue homeostasis and have roles in many physiological and pathological processes. In this context, plant-derived vesicles started to receive attention as valid alternatives to EVs released by mammalian cell. Going beyond the state-of-the-art and relying on a highly interconnected approach, FarmEVs project will setup a vegetable-based system for the massive production of vesicles and explore them as high-value ingredients for plant and human health. This will be achieved through the isolation and engineerization of EV-like nanovesicles from organically grown crops. Plant derived-vesicles will be exploited for sustainable agriculture with the help of an organic farm in Finland and an agricultural university in Egypt. Moreover, we will setup plant cell cultures for EV farming and by applying emerging biotechnology we will develop EV-based solutions to increase the viral resistance of plants and the pro-symbiotic activities in legume crops.
To achieve the goals, a multidisciplinary consortium with the participation of 8 partners from universities, research centres, an SME and an organic farm from 6 countries has been created with the integration of a broad expertise ranging from EV research, biomembrane modelling, plant genetics, plant physiology, virology, molecular farming, engineering and agriculture. This project will strengthen the already existing collaborations, create new ones and provide a solid cornerstone for further research efforts of the consortium participants after the ending of the project. An ambitious staff exchange programme for the transfer of scientific and transferable skills, dissemination and outreach activities was implemented into the scientific plan.
Fields of science
Not validated
Not validated
- natural sciencesbiological sciencesmicrobiologyvirology
- natural sciencesbiological sciencesbiochemistrybiomoleculesproteins
- natural sciencesbiological sciencesbiochemistrybiomoleculeslipids
- medical and health sciencesbasic medicinephysiologyhomeostasis
- agricultural sciencesagriculture, forestry, and fisheriesagriculturegrains and oilseedslegumes
Keywords
Programme(s)
- HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA) Main Programme
Funding Scheme
HORIZON-TMA-MSCA-SE - HORIZON TMA MSCA Staff ExchangesCoordinator
00185 Roma
Italy