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CORDIS

Development of a multimodal toolbox to ensure a fast and reliable diagnosis of consciousness disorders

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Online questionnaire on new behavioural signs of consciousness (opens in new window)

Partners will elaborate an (English) online questionnaire related to the newly highlighted signs of consciousness to collect expert opinions regarding the subsequent creation of the NCB scale (i.e. choice of items, administration guidelines, scoring criteria).

SAFE Online version available (opens in new window)

The SAFE will be implemented as an online version to make its use even easier for informal caregivers.

Report on results of training activities and workshops - mid-term (opens in new window)

All implemented trainings will focus on the following topics: Diagnosis and evaluation techniques including scales assessment, eye-tracking measures, EEG, fMRI, etc; Additional care management or caregivers engagement issues; Transversal research topics: research project management, ethics, data quality, scientific writing, proposal preparation, research integrity, etc.; Soft skills: entrepreneurship and business, IPR issues, dissemination and exploitation skills, etc.

Literature review on electrophysiology and neuroimaging to diagnose DoC patients (opens in new window)

Partners will perform a systematic literature review on existing electrophysiological and neuroimaging evidence to diagnose DoC patients. For that, they will have access to scientific databases and publications of relevant organisms at international and national level. The added value of this common literature review will be also the access to publications in all the languages of the consortium. The systematic review will rely on published data of the European Guidelines, and will integrate them with the most recent evidence. Methodologically, we will follow the same procedures as described in the systematic review performed in the European Guidelines for DoC diagnosis, in which our partners were directly involved.

Training activities design and planning (opens in new window)

A planning will be designed to organise the training rationale, logistics and communication of the foreseen activities.

DoCBox website online (opens in new window)

A website will be created, making all results available also for caregivers and families.

Plan for dissemination and exploitation including communication activities (opens in new window)

Based largely on the information from the preceding tasks, we will develop draft and final versions of an Exploitation Plan. This plan will address issues from the preceding task and additional “big picture” information such as major risks/barriers, an exploitation timeline and recommendations. The draft version will be shared to seek feedback to improve the final version. These two versions will be provided in M36 and M48, as part of D6.3 and D6.4, respectively.

Data management plan (opens in new window)

Throughout this project, we must address secure data handling. This task is devoted to keeping DoCBox data safe through hardware, software and procedures. G.TEC MEDICAL will provide secure data storage at no cost to the project because they already have a very secure server with ample storage space and software protection. The server is located in a locked cage inside a locked room that only opens into the office of G.TEC MEDICAL's IT Director (who locks his office when he is gone), and the G.TEC MEDICAL building is also physically secure. G.TEC MEDICAL staff are used to guidelines and procedures for handling secure data from patients and will heed them in DoCBox. Any concerns about a breach of data security will be immediately reported to the Project Coordinator. This task will also aim to make FAIR data a reality and develop strategies and skills to implement open sciences practices (see details in Section 1.2). This task will also include ethical committee approval management.

Publications

Psilocybin for disorders of consciousness: A case-report study (opens in new window)

Author(s): Paolo Cardone, Pablo Núñez, Naji L.N. Alnagger, Charlotte Martial, Glenn J.M. van der Lande, Robin Sandell, Robin Carhart-Harris, Olivia Gosseries
Published in: Clinical Neurophysiology, Issue 173, 2025, ISSN 1388-2457
Publisher: Elsevier BV
DOI: 10.1016/J.CLINPH.2025.02.264

Expert Review of Neurotherapeutics (opens in new window)

Author(s): Girard Pepin, Fatemeh Seyfzadeh , David Williamson, Olivia Gosseries , Catherine Duclos
Published in: EXPERT REVIEW OF NEUROTHERAPEUTICS, Issue 25, ISSN 1473-7175
Publisher: Taylor & Francis
DOI: 10.1080/14737175.2025.2500757

Pharmacological therapies for early and long-term recovery in disorders of consciousness: current knowledge and promising avenues (opens in new window)

Author(s): Rosalie Girard Pepin, Fatemeh Seyfzadeh, David Williamson, Olivia Gosseries, Catherine Duclos
Published in: Expert Review of Neurotherapeutics, Issue 25, 2025, ISSN 1473-7175
Publisher: Informa UK Limited
DOI: 10.1080/14737175.2025.2500757

The social and family evaluation (SAFE) scale for caregivers of individuals with disorders of consciousness: preliminary results (opens in new window)

Author(s): F. G. Magnani, M. Cacciatore, F. Barbadoro, C. Ippoliti, D. Sattin, A. Magliacano, F. Draghi, A. De Nisco, B. Hakiki, F. Cecchi, M. Spinola, A. Estraneo, M. Leonardi
Published in: Neurological Sciences, Issue 46, 2025, ISSN 1590-1874
Publisher: Springer Science and Business Media LLC
DOI: 10.1007/S10072-024-07685-4

Altered electrophysiological meta-state dynamics in disorders of consciousness (opens in new window)

Author(s): Pablo Núñez, Prejaas Tewarie, Víctor Rodríguez-González, Naji L.N. Alnagger, Glenn J.M. van der Lande, Marie M. Vitello, Paolo Cardone, Aurore Thibaut, Laouen Belloli, Steven Laureys, Jacobo D. Sitt, Jitka Annen, Olivia Gosseries
Published in: NeuroImage, Issue 323, 2026, ISSN 1053-8119
Publisher: Elsevier BV
DOI: 10.1016/J.NEUROIMAGE.2025.121519

Diagnosing awareness in disorders of consciousness with gamma-band auditory responses (opens in new window)

Author(s): Marek Binder, Julia Papiernik, Inga Griskova-Bulanova, Sandra Frycz, Bartłomiej Chojnacki, Urszula Górska-Klimowska
Published in: Frontiers in Human Neuroscience, Issue 17, 2024, ISSN 1662-5161
Publisher: Frontiers Media SA
DOI: 10.3389/FNHUM.2023.1243051

Distinct Spectral Profiles of Awake Resting EEG in Disorders of Consciousness: The Role of Frequency and Topography of Oscillations (opens in new window)

Author(s): Dominika Drążyk, Karol Przewrocki, Urszula Górska-Klimowska, Marek Binder
Published in: Brain Topography, Issue 37, 2024, ISSN 0896-0267
Publisher: Springer Science and Business Media LLC
DOI: 10.1007/S10548-023-01024-0

Lateral frontoparietal effective connectivity differentiates and predicts state of consciousness in a cohort of patients with traumatic disorders of consciousness (opens in new window)

Author(s): Riku Ihalainen, Jitka Annen, Olivia Gosseries, Paolo Cardone, Rajanikant Panda, Charlotte Martial, Aurore Thibaut, Steven Laureys, Srivas Chennu
Published in: PLOS ONE, Issue 19, 2024, ISSN 1932-6203
Publisher: Public Library of Science (PLoS)
DOI: 10.1371/JOURNAL.PONE.0298110

Swallowing Assessment in Post-Comatose Patients: A Feasibility Study on the SWADOC Tool (opens in new window)

Author(s): Roxanne Herr, Amandine Regnier , Marion Belorgeot, Evelyne Mélotte , Jessica Simon , Leandro R D Sanz , Nicolas Lejeune , Valérie Chavet , Jenny Paluszkiewicz, Frédéric Pellas, Jean-Baptiste Chevallier
Published in: Journal of Clinical Medicine, ISSN 2077-0383
Publisher: MDPI AG
DOI: 10.3390/JCM13113268

Transauricular Vagus Nerve Stimulation and Electroencephalographic Assessment in Disorders of Consciousness (opens in new window)

Author(s): Samuel López-Rodríguez, Alejandro Galvao-Carmona, Myrtha O‘Valle-Rodríguez, Barbara Postigo-Alonso, Marta Gómez-Herranz, María D. Navarro-Pérez, Joan Ferri-Campos, Enrique Noé-Sebastián
Published in: Journal of Visualized Experiments, 2025, ISSN 1940-087X
Publisher: MyJove Corporation
DOI: 10.3791/68062

Handbook of Clinical Neurology (opens in new window)

Author(s): Marie M. Vitello, Steven Laureys, Aurore Thibaut, Olivia Gosseries
Published in: Handbook of Clinical Neurology, Coma, Stupor, and Related Disorders of Consciousness, 2025, ISSN 0072-9752
Publisher: Elsevier Science Inc.
DOI: 10.1016/B978-0-443-13408-1.00007-5

Can Eye Tracking Help Assess the State of Consciousness in Non-Verbal Brain Injury Patients? (opens in new window)

Author(s): Grzegorz Zurek, Marek Binder, Bartosz Kunka, Robert Kosikowski, Małgorzata Rodzeń, Danuta Karaś, Gabriela Mucha, Roman Olejniczak, Agata Gorączko, Katarzyna Kujawa, Anna Stachowicz, Karolina Kryś-Noszczyk, Joanna Dryjska, Marcin Dryjski, Jarosław Szczygieł
Published in: Journal of Clinical Medicine, Issue 13, 2025, ISSN 2077-0383
Publisher: MDPI AG
DOI: 10.3390/JCM13206227

Characterization of responders to transcranial direct current stimulation in disorders of consciousness: A retrospective study of 8 clinical trials (opens in new window)

Author(s): Alice Barra, Rodrigo Huerta-Gutierrez, Jitka Annen, Geraldine Martens, Steven Laureys, Roberto Llorens, Tobias Kurth, Aurore Thibaut
Published in: Neurotherapeutics, Issue 22, 2025, ISSN 1878-7479
Publisher: Elsevier BV
DOI: 10.1016/J.NEUROT.2025.E00587

Advances in neuroimaging in disorders of consciousness (opens in new window)

Author(s): Arianna Sala, Olivia Gosseries, Steven Laureys, Jitka Annen
Published in: Handbook of Clinical Neurology, Coma, Stupor, and Related Disorders of Consciousness, 2025
Publisher: Elsevier
DOI: 10.1016/B978-0-443-13408-1.00008-7

Brain–Computer Interfaces and Their Place in the Management of Disorders of Consciousness (opens in new window)

Author(s): Michiel Meys, Aurore Thibaut, Jitka Annen
Published in: Coma and Disorders of Consciousness, 2024
Publisher: Springer International Publishing
DOI: 10.1007/978-3-031-50563-8_3

Non-pharmacologic interventions in disorders of consciousness (opens in new window)

Author(s): Marie M Vitello, Steven Laureys, Aurore Thibaut, Olivia Gosseries
Published in: 2025, ISSN 3998-6722
Publisher: Elsevier
DOI: 10.1016/B978-0-443-13408-1.00007-5

Online questionnaire on new behavioural signs of consciousness

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