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CORDIS - Risultati della ricerca dell’UE
CORDIS

Development of a multimodal toolbox to ensure a fast and reliable diagnosis of consciousness disorders

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Online questionnaire on new behavioural signs of consciousness (si apre in una nuova finestra)

Partners will elaborate an (English) online questionnaire related to the newly highlighted signs of consciousness to collect expert opinions regarding the subsequent creation of the NCB scale (i.e. choice of items, administration guidelines, scoring criteria).

SAFE Online version available (si apre in una nuova finestra)

The SAFE will be implemented as an online version to make its use even easier for informal caregivers.

Report on results of training activities and workshops - mid-term (si apre in una nuova finestra)

All implemented trainings will focus on the following topics: Diagnosis and evaluation techniques including scales assessment, eye-tracking measures, EEG, fMRI, etc; Additional care management or caregivers engagement issues; Transversal research topics: research project management, ethics, data quality, scientific writing, proposal preparation, research integrity, etc.; Soft skills: entrepreneurship and business, IPR issues, dissemination and exploitation skills, etc.

Literature review on electrophysiology and neuroimaging to diagnose DoC patients (si apre in una nuova finestra)

Partners will perform a systematic literature review on existing electrophysiological and neuroimaging evidence to diagnose DoC patients. For that, they will have access to scientific databases and publications of relevant organisms at international and national level. The added value of this common literature review will be also the access to publications in all the languages of the consortium. The systematic review will rely on published data of the European Guidelines, and will integrate them with the most recent evidence. Methodologically, we will follow the same procedures as described in the systematic review performed in the European Guidelines for DoC diagnosis, in which our partners were directly involved.

Training activities design and planning (si apre in una nuova finestra)

A planning will be designed to organise the training rationale, logistics and communication of the foreseen activities.

DoCBox website online (si apre in una nuova finestra)

A website will be created, making all results available also for caregivers and families.

Plan for dissemination and exploitation including communication activities (si apre in una nuova finestra)

Based largely on the information from the preceding tasks, we will develop draft and final versions of an Exploitation Plan. This plan will address issues from the preceding task and additional “big picture” information such as major risks/barriers, an exploitation timeline and recommendations. The draft version will be shared to seek feedback to improve the final version. These two versions will be provided in M36 and M48, as part of D6.3 and D6.4, respectively.

Data management plan (si apre in una nuova finestra)

Throughout this project, we must address secure data handling. This task is devoted to keeping DoCBox data safe through hardware, software and procedures. G.TEC MEDICAL will provide secure data storage at no cost to the project because they already have a very secure server with ample storage space and software protection. The server is located in a locked cage inside a locked room that only opens into the office of G.TEC MEDICAL's IT Director (who locks his office when he is gone), and the G.TEC MEDICAL building is also physically secure. G.TEC MEDICAL staff are used to guidelines and procedures for handling secure data from patients and will heed them in DoCBox. Any concerns about a breach of data security will be immediately reported to the Project Coordinator. This task will also aim to make FAIR data a reality and develop strategies and skills to implement open sciences practices (see details in Section 1.2). This task will also include ethical committee approval management.

Pubblicazioni

Psilocybin for disorders of consciousness: A case-report study (si apre in una nuova finestra)

Autori: Paolo Cardone, Pablo Núñez, Naji L.N. Alnagger, Charlotte Martial, Glenn J.M. van der Lande, Robin Sandell, Robin Carhart-Harris, Olivia Gosseries
Pubblicato in: Clinical Neurophysiology, Numero 173, 2025, ISSN 1388-2457
Editore: Elsevier BV
DOI: 10.1016/J.CLINPH.2025.02.264

Pharmacological therapies for early and long-term recovery in disorders of consciousness: current knowledge and promising avenues (si apre in una nuova finestra)

Autori: Rosalie Girard Pepin, Fatemeh Seyfzadeh, David Williamson, Olivia Gosseries, Catherine Duclos
Pubblicato in: Expert Review of Neurotherapeutics, Numero 25, 2025, ISSN 1473-7175
Editore: Informa UK Limited
DOI: 10.1080/14737175.2025.2500757

The social and family evaluation (SAFE) scale for caregivers of individuals with disorders of consciousness: preliminary results (si apre in una nuova finestra)

Autori: F. G. Magnani, M. Cacciatore, F. Barbadoro, C. Ippoliti, D. Sattin, A. Magliacano, F. Draghi, A. De Nisco, B. Hakiki, F. Cecchi, M. Spinola, A. Estraneo, M. Leonardi
Pubblicato in: Neurological Sciences, Numero 46, 2025, ISSN 1590-1874
Editore: Springer Science and Business Media LLC
DOI: 10.1007/S10072-024-07685-4

Altered electrophysiological meta-state dynamics in disorders of consciousness (si apre in una nuova finestra)

Autori: Pablo Núñez, Prejaas Tewarie, Víctor Rodríguez-González, Naji L.N. Alnagger, Glenn J.M. van der Lande, Marie M. Vitello, Paolo Cardone, Aurore Thibaut, Laouen Belloli, Steven Laureys, Jacobo D. Sitt, Jitka Annen, Olivia Gosseries
Pubblicato in: NeuroImage, Numero 323, 2026, ISSN 1053-8119
Editore: Elsevier BV
DOI: 10.1016/J.NEUROIMAGE.2025.121519

Diagnosing awareness in disorders of consciousness with gamma-band auditory responses (si apre in una nuova finestra)

Autori: Marek Binder, Julia Papiernik, Inga Griskova-Bulanova, Sandra Frycz, Bartłomiej Chojnacki, Urszula Górska-Klimowska
Pubblicato in: Frontiers in Human Neuroscience, Numero 17, 2024, ISSN 1662-5161
Editore: Frontiers Media SA
DOI: 10.3389/FNHUM.2023.1243051

Distinct Spectral Profiles of Awake Resting EEG in Disorders of Consciousness: The Role of Frequency and Topography of Oscillations (si apre in una nuova finestra)

Autori: Dominika Drążyk, Karol Przewrocki, Urszula Górska-Klimowska, Marek Binder
Pubblicato in: Brain Topography, Numero 37, 2024, ISSN 0896-0267
Editore: Springer Science and Business Media LLC
DOI: 10.1007/S10548-023-01024-0

Lateral frontoparietal effective connectivity differentiates and predicts state of consciousness in a cohort of patients with traumatic disorders of consciousness (si apre in una nuova finestra)

Autori: Riku Ihalainen, Jitka Annen, Olivia Gosseries, Paolo Cardone, Rajanikant Panda, Charlotte Martial, Aurore Thibaut, Steven Laureys, Srivas Chennu
Pubblicato in: PLOS ONE, Numero 19, 2024, ISSN 1932-6203
Editore: Public Library of Science (PLoS)
DOI: 10.1371/JOURNAL.PONE.0298110

Transauricular Vagus Nerve Stimulation and Electroencephalographic Assessment in Disorders of Consciousness (si apre in una nuova finestra)

Autori: Samuel López-Rodríguez, Alejandro Galvao-Carmona, Myrtha O‘Valle-Rodríguez, Barbara Postigo-Alonso, Marta Gómez-Herranz, María D. Navarro-Pérez, Joan Ferri-Campos, Enrique Noé-Sebastián
Pubblicato in: Journal of Visualized Experiments, 2025, ISSN 1940-087X
Editore: MyJove Corporation
DOI: 10.3791/68062

Handbook of Clinical Neurology (si apre in una nuova finestra)

Autori: Marie M. Vitello, Steven Laureys, Aurore Thibaut, Olivia Gosseries
Pubblicato in: Handbook of Clinical Neurology, Coma, Stupor, and Related Disorders of Consciousness, 2025, ISSN 0072-9752
Editore: Elsevier Science Inc.
DOI: 10.1016/B978-0-443-13408-1.00007-5

Can Eye Tracking Help Assess the State of Consciousness in Non-Verbal Brain Injury Patients? (si apre in una nuova finestra)

Autori: Grzegorz Zurek, Marek Binder, Bartosz Kunka, Robert Kosikowski, Małgorzata Rodzeń, Danuta Karaś, Gabriela Mucha, Roman Olejniczak, Agata Gorączko, Katarzyna Kujawa, Anna Stachowicz, Karolina Kryś-Noszczyk, Joanna Dryjska, Marcin Dryjski, Jarosław Szczygieł
Pubblicato in: Journal of Clinical Medicine, Numero 13, 2025, ISSN 2077-0383
Editore: MDPI AG
DOI: 10.3390/JCM13206227

Characterization of responders to transcranial direct current stimulation in disorders of consciousness: A retrospective study of 8 clinical trials (si apre in una nuova finestra)

Autori: Alice Barra, Rodrigo Huerta-Gutierrez, Jitka Annen, Geraldine Martens, Steven Laureys, Roberto Llorens, Tobias Kurth, Aurore Thibaut
Pubblicato in: Neurotherapeutics, Numero 22, 2025, ISSN 1878-7479
Editore: Elsevier BV
DOI: 10.1016/J.NEUROT.2025.E00587

Advances in neuroimaging in disorders of consciousness (si apre in una nuova finestra)

Autori: Arianna Sala, Olivia Gosseries, Steven Laureys, Jitka Annen
Pubblicato in: Handbook of Clinical Neurology, Coma, Stupor, and Related Disorders of Consciousness, 2025
Editore: Elsevier
DOI: 10.1016/B978-0-443-13408-1.00008-7

Brain–Computer Interfaces and Their Place in the Management of Disorders of Consciousness (si apre in una nuova finestra)

Autori: Michiel Meys, Aurore Thibaut, Jitka Annen
Pubblicato in: Coma and Disorders of Consciousness, 2024
Editore: Springer International Publishing
DOI: 10.1007/978-3-031-50563-8_3

Non-pharmacologic interventions in disorders of consciousness (si apre in una nuova finestra)

Autori: Marie M Vitello, Steven Laureys, Aurore Thibaut, Olivia Gosseries
Pubblicato in: 2025, ISSN 3998-6722
Editore: Elsevier
DOI: 10.1016/B978-0-443-13408-1.00007-5

Online questionnaire on new behavioural signs of consciousness

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