Objective
Liver cirrhosis and liver cancer are common and responsible for high morbidity, impaired quality of life, major costs for healthcare systems, causing 300K deaths per year in Europe. Predominant etiological factors are obesity, type2 diabetes, and increased alcohol in-take, which are all on the rise. It is predicted that healthy life expectancy will decrease in Europe over the next 30 years because of deaths due to liver disease. Liver cirrhosis develops after a very long period of asymptomatic liver fibrosis, staying undetected until patients develop severe complications due to cirrhosis or liver cancer. Currently the only effective treatment available is liver transplantation which is not applicable to all patients. If fibrosis is detected early, to target the course of liver disease, then liver fibrosis is reversible. The LIVERAIM project concentrates a team of renowned clinical centres and Industrial partners, including SMEs, with great expertise in the field of Liver Disease, the aim being to design and validate a screening platform with biomarkers for population screening to use across Europe. The objective is to identify liver disease early and apply personalized therapeutic interventions. A large number of existing biomarkers will be tested for fibrosis prediction accuracy using biobank plasma samples from 40,000 subjects from previous H2020 EU-funded cohorts. LIVERAIM will develop a screening platform with biomarkers using AI for personalized early diagnosis of fibrosis to be validated in a RCT of 100K subjects from 6 representative EU countries. The platform will be linked to tailored, personalized therapeutic interventions to halt fibrosis progression. With LIVERAIM, early diagnosis and personalized intervention can stop liver disease progression, help decrease morbidity and mortality and the associated societal burdens both economic and health inequity.
Fields of science
- medical and health sciencesclinical medicineoncologyliver cancer
- medical and health sciencesclinical medicineendocrinologydiabetes
- medical and health sciencesclinical medicinehepatology
- medical and health sciencesclinical medicinetransplantation
- medical and health scienceshealth sciencesnutritionobesity
Keywords
Programme(s)
- HORIZON.2.1 - Health Main Programme
- HORIZON.2.1.7 - Innovative Health Initiative
Funding Scheme
HORIZON-JU-RIA - HORIZON JU Research and Innovation ActionsCoordinator
08036 Barcelona
Spain
See on map
Participants (26)
Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.
08036 Barcelona
See on map
7100 Vejle
See on map
55131 Mainz
See on map
35122 Padova
See on map
Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.
35128 Padova
See on map
75013 Paris
See on map
Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.
75012 Paris
See on map
10000 ZAGREB
See on map
Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.
10000 Zagreb
See on map
10124 Torino
See on map
975 17 BANSKA BYSTRICA
See on map
08036 Barcelona
See on map
08007 Barcelona
See on map
08193 Cerdanyola Del Valles
See on map
1050 Bruxelles / Brussel
See on map
53100 Siena
See on map
The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
6343 Rotkreuz
See on map
91052 Erlangen
See on map
2730 Herlev
See on map
The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
22848 Norderstedt
See on map
75014 Paris
See on map
151 85 Sodertaelje
See on map
55218 Ingelheim
See on map
2880 Bagsvaerd
See on map
CARRIGTOOHILL
See on map
66123 Saarbrucken
See on map
Partners (4)
1203 Geneve
See on map
8006 Zurich
See on map
55905 Rochester
See on map
NE1 7RU Newcastle Upon Tyne
See on map