Project description
Early diagnosis and tailored interventions for liver disease
Liver cirrhosis and liver cancer are prevalent in Europe, causing 300 000 deaths annually. Etiological factors such as obesity, diabetes, and alcohol consumption are on the rise, contributing to the increasing burden of liver disease. Unfortunately, liver fibrosis often remains undetected until advanced stages, limiting treatment options to transplantation. In this context, the EU-funded LIVERAIM project aims to pioneer a screening platform using biomarkers for early detection and personalised therapeutic interventions. Specifically, the project brings together clinical centres and industrial partners to develop a screening platform. By analysing biobank samples from 25 000 subjects and conducting a randomised controlled trial involving 100 000 individuals across six EU countries, LIVERAIM aims to validate personalised therapeutic interventions.
Objective
Liver cirrhosis and liver cancer are common and responsible for high morbidity, impaired quality of life, major costs for healthcare systems, causing 300K deaths per year in Europe. Predominant etiological factors are obesity, type2 diabetes, and increased alcohol in-take, which are all on the rise. It is predicted that healthy life expectancy will decrease in Europe over the next 30 years because of deaths due to liver disease. Liver cirrhosis develops after a very long period of asymptomatic liver fibrosis, staying undetected until patients develop severe complications due to cirrhosis or liver cancer. Currently the only effective treatment available is liver transplantation which is not applicable to all patients. If fibrosis is detected early, to target the course of liver disease, then liver fibrosis is reversible. The LIVERAIM project concentrates a team of renowned clinical centres and Industrial partners, including SMEs, with great expertise in the field of Liver Disease, the aim being to design and validate a screening platform with biomarkers for population screening to use across Europe. The objective is to identify liver disease early and apply personalized therapeutic interventions. A large number of existing biomarkers will be tested for fibrosis prediction accuracy using biobank plasma samples from 40,000 subjects from previous H2020 EU-funded cohorts. LIVERAIM will develop a screening platform with biomarkers using AI for personalized early diagnosis of fibrosis to be validated in a RCT of 100K subjects from 6 representative EU countries. The platform will be linked to tailored, personalized therapeutic interventions to halt fibrosis progression. With LIVERAIM, early diagnosis and personalized intervention can stop liver disease progression, help decrease morbidity and mortality and the associated societal burdens both economic and health inequity.
Fields of science
- medical and health sciencesclinical medicineoncologyliver cancer
- medical and health sciencesclinical medicineendocrinologydiabetes
- medical and health sciencesclinical medicinehepatology
- medical and health sciencesclinical medicinetransplantation
- medical and health scienceshealth sciencesnutritionobesity
Keywords
Programme(s)
- HORIZON.2.1 - Health Main Programme
- HORIZON.2.1.7 - Innovative Health Initiative
Funding Scheme
HORIZON-JU-RIA - HORIZON JU Research and Innovation ActionsCoordinator
08036 Barcelona
Spain
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Participants (26)
Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.
08036 Barcelona
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7100 Vejle
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55131 Mainz
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35122 Padova
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Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.
35128 Padova
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75013 Paris
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Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.
75012 Paris
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10000 ZAGREB
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Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.
10000 Zagreb
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10124 Torino
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975 17 BANSKA BYSTRICA
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08036 Barcelona
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08007 Barcelona
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08193 Cerdanyola Del Valles
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1050 Bruxelles / Brussel
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53100 Siena
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
6343 Rotkreuz
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91052 Erlangen
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2730 Herlev
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
22848 Norderstedt
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75014 Paris
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151 85 Sodertaelje
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55218 Ingelheim
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2880 Bagsvaerd
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CARRIGTOOHILL
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66123 Saarbrucken
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Partners (4)
Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
1203 Geneve
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
8006 Zurich
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
55905 Rochester
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
NE1 7RU Newcastle Upon Tyne
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