Descripción del proyecto
Detección de contaminantes bióticos y abióticos con biosensores
La detección de contaminantes abióticos y bióticos es fundamental en las aplicaciones medioambientales. El objetivo del proyecto BIOSENSEI, financiado con fondos europeos, es desarrollar una plataforma de biosensores para detectar ambos tipos de contaminantes a través de las respuestas celulares. Estos biosensores se encapsularán e inmovilizarán en transductores bimodales, lo que posibilitará una detección muy sensible y fiable de los contaminantes objetivo. Además, en el proyecto se crearán frontales analógicos de consumo ultrabajo y nodos finales de internet de las cosas autónomos para la adquisición de datos, lo que facilitará la integración en redes de largo alcance existentes y proporcionará datos al instante. Un panel de control en línea permitirá a los usuarios finales visualizar los datos. El proyecto se desarrollará en un marco seguro y sostenible y contribuirá de forma notable al objetivo de contaminación cero de la Unión Europea.
Objetivo
BIOSENSEI develops a real-time, multiplexed, end-to-end, tailored and reliable biosensor platform, using cellular responses, for detection of abiotic pollutants - Nutrients, Estrogenic endocrine-disrupting chemicals, and PFAS (Perfluoroalkyl and Polyfluoroalkyl Substances); and biotic pollutants - Microcystins. Cellular biosensors from bacterial variants will be genetically engineered using, RNA-RNA interactive and type III CRISPR-Cas-mediated transduction cascades. These biosensors are encapsulated and immobilised at bi-modal transducers (nanoelectrochemical and optical) to provide highly reliable, tuneable and sensitive detection of the target pollutants. Bespoke ultra-low power analog front ends and autonomous IoT end-nodes will enable operation and data acquisition from biosensors and facilitate easy integration in existing LoRa networks enabling real-time data feeds. Neural computing algorithms are embedded on the edge to correct for sensor aging and interferents in the (bio)chemical transduction and improve sensor data accuracy. An online dashboard will be developed to allow end users to visualize data. BIOSENSEI will embed the whole R&D process within a safe-and-sustainable-by-design framework to guarantee environmental safety related to risks of potential release into the open environment. Biosensors will be scalable, adaptable to different applications in water & soil and will be deployed in four different use-cases. The consortium is vertically integrated bringing expertise in cellular biology, surface chemistry, nanoelectronics fabrication, hardware integration, regulatory and industrial sampling and artificial intelligence. BIOSENSEI directly addresses HORIZON-CL6-2023-ZEROPOLLUTION-01-6 Biosensors and user-friendly diagnostic tools for environmental services and will allow cellular biosensors to be deployed outside laboratory settings for the first time the project and has the potential to considerably contribute to fulfil EU vision on zero-pollution.
Ámbito científico
- natural sciencescomputer and information sciencesartificial intelligence
- engineering and technologyelectrical engineering, electronic engineering, information engineeringelectronic engineeringsensorsbiosensors
- natural sciencescomputer and information sciencesinternetinternet of things
- engineering and technologynanotechnologynanoelectronics
Palabras clave
Programa(s)
Convocatoria de propuestas
HORIZON-CL6-2023-ZEROPOLLUTION-01
Consulte otros proyectos de esta convocatoriaRégimen de financiación
HORIZON-RIA - HORIZON Research and Innovation ActionsCoordinador
T12 YN60 Cork
Irlanda