AcceleRating the Translation of virtual twins towards a pErsonalised Management of fatty lIver patients

Información del proyecto

ARTEMIS

Identificador del acuerdo de subvención: 101136299

DOI

10.3030/101136299

Fecha de la firma de la CE 7 Diciembre 2023

Fecha de inicio 1 Enero 2024

Fecha de finalización 31 Diciembre 2027

Financiado con arreglo a

• Health

Coste total

€ 9 365 096,00

Aportación de la UE

€ 9 365 095,00

Coordinado por

MATICAL INNOVATION SL
Spain

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Documents, reports (7)

ARTEMIs value propostion for the different target groups, learnt from interviews and questionnaires

ARTEMIs value proposition for the different target groups, learnt from interviews and questionnaires.

Ethics guidance report, Ethics Impact Assessment
Description of submodel developments by each model expert
Description of all image processing research activities
Project dissemination and communication plan, including Open Science management and website

Project dissemination and communication plan, including Open Science management and website

Exploitation plan

Initial exploitation plan for the main project outputs.

Record of dissemination and communication actions undertaken in the previous 12 months, and updated plan

Publicaciones

Peer reviewed articles (30)

Improving Vessel Segmentation with Multi-Task Learning and Auxiliary Data Available Only During Model Training

Autores: Daniel Sobotka, Alexander Herold, Matthias Perkonigg, Lucian Beer, Nina Bastati, Alina Sablatnig, Ahmed Ba-Ssalamah, Georg Langs
Publicado en: Computerized Medical Imaging and Graphics, Edición 114, 2024, ISSN 0895-6111
Editor: Elsevier BV
DOI: 10.1016/J.COMPMEDIMAG.2024.102369

Assessment and management of portal hypertension in patients with MASLD: advances and caveats

Autores: Diego Rojo, Alba Jiménez-Masip, Laura Pagès, Juan Bañares, Clara Sabiote, María Martínez-Gómez, Laia Aceituno, M. Serra Cusidó, M. Teresa Salcedo-Allende, Zyanya Calixto, Mònica Pons, Joan Genescà, Juan M. Pericàs
Publicado en: Expert Review of Gastroenterology & Hepatology, 2025, ISSN 1747-4124
Editor: Informa UK Limited
DOI: 10.1080/17474124.2025.2530605

Influence of Low-dose Acetylsalicylic Acid on Renal Function in Patients With Liver Cirrhosis and Ascites

Autores: Henrik Karbannek, Marina Reljic, Andreas Stallmach, Alexander Zipprich, Cristina Ripoll
Publicado en: Clinical Gastroenterology and Hepatology, Edición 23, 2025, ISSN 1542-3565
Editor: Elsevier BV
DOI: 10.1016/J.CGH.2025.02.005

A comparative study of lumped heart models for personalized medicine through sensitivity and identifiability analysis

Autores: Marie Haghebaert, Pavlos Varsos, Roel Meiburg, Irene Vignon‐Clementel
Publicado en: The Journal of Physiology, 2025, ISSN 0022-3751
Editor: Wiley
DOI: 10.1113/JP287929

Editorial: Three‐Dimensional (<scp>3D</scp>) Geometric Modelling in <scp>TIPS</scp> Implantation—A Further Step Toward Personalised Portal Pressure Reduction?

Autores: Alexander Zipprich, Cristina Ripoll
Publicado en: Alimentary Pharmacology &amp; Therapeutics, Edición 62, 2025, ISSN 0269-2813
Editor: Wiley
DOI: 10.1111/APT.70175

Steatotic liver disease and HIV: an agenda for 2030

Autores: Juan M Pericàs, Anish K Arora, Carlotta Riebensahm, Alba Jiménez-Masip, Adrià Ramírez Mena, Trenton M White, Nikos Dedes, Giovanni Guaraldi, Annalisa Berzigotti, Gilles Wandeler, Meena B Bansal, Jordi Navarro, Jeffrey V Lazarus
Publicado en: The Lancet HIV, Edición 11, 2024, ISSN 2352-3018
Editor: Elsevier BV
DOI: 10.1016/S2352-3018(24)00097-3

THU-156 Clinical predictors of increased liver stiffness over time in metabolic dysfunction-associated steatotic liver disease: a prospective real-life study

Autores: Stephanie Andre-Dumont, Joyce Scholtens, Nicolas Lanthier
Publicado en: Journal of Hepatology, Edición 84, 2026, ISSN 0168-8278
Editor: Elsevier BV
DOI: 10.1016/S0168-8278(26)01554-0

Interaction of inflammation and portal hypertension in cirrhosis progression

Autores: Dalila Costa, Jonel Trebicka, Cristina Ripoll, Richard Moreau, Rajiv Jalan, Thomas Reiberger
Publicado en: Nature Reviews Gastroenterology &amp; Hepatology, 2025, ISSN 1759-5045
Editor: Springer Science and Business Media LLC
DOI: 10.1038/S41575-025-01107-2

Diclofenac and acetaminophen dim the acute-phase response but amplify expression of the iron regulator hepcidin in liver cancer cells

Autores: Anja Zeilfelder, Joep Vanlier, Christina Mölders, Philipp Kastl, Barbara Helm, Sebastian Burbano de Lara, Till Möcklinghoff, Nantia Leonidou, Elisa Holstein, Artyom Vlasov, Alexander Held, Silvana Wilken, Katrin Hoffmann, Gerda Schicht, Andrea Scheffschick, Markella Katerinopoulou, Esther Giehl-Brown, Christoph Kahlert, Christoph Michalski, Daniel Seehofer, Georg Damm, Martina U. Muckenthaler, Marcel Schilling, Jens Timmer, Ursula Klingmüller
Publicado en: Cell Systems, Edición 16, 2026, ISSN 2405-4712
Editor: Elsevier BV
DOI: 10.1016/J.CELS.2025.101431

Functional liver imaging score (FLIS): A prognostic biomarker for acute-on-chronic liver failure and liver-related mortality

Autores: Sarah Poetter-Lang, Lorenz Balcar, Ahmed Ba-Ssalamah, Nina Bastati, Raphael Ambros, Antonia Kristic, Julia Krawanja, Katharina Pomej, Benedikt Simbrunner, Georg Semmler, Victor Schmidbauer, Svitlana Pochepnia, Daniel Sobotka, Jacqueline C. Hodge, Ulrike Attenberger, Michael Trauner, Thomas Reiberger, Lucian Beer, Mattias Mandorfer
Publicado en: JHEP Reports, Edición 8, 2026, ISSN 2589-5559
Editor: Elsevier BV
DOI: 10.1016/J.JHEPR.2026.101928

Interaction of inflammation and portal hypertension in cirrhosis progression

Autores: Dalila Costa, Jonel Trebicka, Cristina Ripoll, Richard Moreau, Rajiv Jalan, Thomas Reiberger
Publicado en: Nature Reviews Gastroenterology &amp; Hepatology, Edición 22, 2025, ISSN 1759-5045
Editor: Springer Science and Business Media LLC
DOI: 10.1038/S41575-025-01107-2

Influence of Low-dose Acetylsalicylic Acid on Renal Function in Patients With Liver Cirrhosis and Ascites

Autores: Henrik Karbannek, Marina Reljic, Andreas Stallmach, Alexander Zipprich, Cristina Ripoll
Publicado en: Clinical Gastroenterology and Hepatology, Edición 23, 2025, ISSN 1542-3565
Editor: Elsevier BV
DOI: 10.1016/J.CGH.2025.02.005

Editorial: Three‐Dimensional (<scp>3D</scp>) Geometric Modelling in <scp>TIPS</scp> Implantation—A Further Step Toward Personalised Portal Pressure Reduction?

Autores: Alexander Zipprich, Cristina Ripoll
Publicado en: Alimentary Pharmacology &amp; Therapeutics, Edición 62, 2025, ISSN 0269-2813
Editor: Wiley
DOI: 10.1111/APT.70175

Correlation between MRI-derived and biopsy-confirmed liver iron concentration in patients with chronic liver disease

Autores: Sami A. Ba-Ssalamah, Michael Schwarz, Sarah Poetter-Lang, Nina Bastati, Ahmet Y. Yitik, Jacqueline C. Hodge, Lucian Beer, Nicolas Balutsch, Albert Friedrich Stättermayer, Michael Trauner, Mattias Mandorfer, Ahmed Ba-Ssalamah, Georg Langs, Benjamin Henninger, Yves Gandon, Ulrike Attenberger, Lukas Haider, Thomas Reiberger
Publicado en: European Journal of Radiology, Edición 194, 2026, ISSN 0720-048X
Editor: Elsevier BV
DOI: 10.1016/J.EJRAD.2025.112484

On the different flavours of practical identifiability

Autores: Mio Heinrich, Rafael Arutjunjan, Jens Timmer
Publicado en: Current Opinion in Systems Biology, Edición 42, 2026, ISSN 2452-3100
Editor: Elsevier BV
DOI: 10.1016/J.COISB.2025.100556

Cost of Metabolic Dysfunction‐Associated Steatotic Liver Disease Screening Among All People Living With Diabetes in Six Countries

Autores: Jeffrey V. Lazarus, Leire Agirre‐Garrido, J. Emilio Miralles‐Sanchez, Melina I. Manolas, Frank Tacke, Cristiane A. Villela‐Nogueira, Hussain Abdulrahman Al‐Omar, Saleh A. Alqahtani, Lamya Mohammed Yahya Alzubaidi, Meena Bansal, Kenneth Cusi, Scott D. Isaacs, Didac Mauricio, Teruki Miyake, Rodrigo O. Moreira, Shoko Nakazawa, Silvana Pannain, Juan M. Pericàs, Michael Roden, Hirokazu Takahashi, Nicolai Brachowicz
Publicado en: Liver International, Edición 45, 2026, ISSN 1478-3223
Editor: Wiley
DOI: 10.1111/LIV.70390

MRI-derived quantification of hepatic vessel-to-volume ratios in chronic liver disease using a deep learning approach

Autores: Alexander Herold, Daniel Sobotka, Lucian Beer, Nina Bastati, Sarah Poetter-Lang, Michael Weber, Thomas Reiberger, Mattias Mandorfer, Georg Semmler, Benedikt Simbrunner, Barbara D. Wichtmann, Sami A. Ba-Ssalamah, Michael Trauner, Ahmed Ba-Ssalamah, Georg Langs
Publicado en: European Radiology Experimental, Edición 9, 2025, ISSN 2509-9280
Editor: Springer Science and Business Media LLC
DOI: 10.1186/S41747-025-00612-Y

Assessing Europe's policy readiness to confront the MASLD/MASH public health threat

Autores: Jeffrey V. Lazarus, Trenton M. White, Leire Agirre-Garrido, Kushala W.M. Abeysekera, Paul N. Brennan, Radan Brůha, Stefan Buttigieg, Patrizia Carrieri, Helena Cortez-Pinto, Robert Flisiak, Sven M.A. Francque, Gema Frühbeck, Liliana Simona Gheorghe, Hannes Hagström, Adriaan G. Holleboom, Krasen Ivanov, Mojca Jensterle, Peter Jepsen, Juozas Kupčinskas, Henry E. Mark, Didac Mauricio, Saba Mohamed Bibi, Christophe Moreno, Anna Mrzljak, Eleni Papanicolaou, Maria Papp, Georgios Papatheodoridis, Markus Peck-Radosavljevic, Nicola Pugliese, John D. Ryan, Rogério T. Ribeiro, Riina Salupere, Lubomir Skladany, Ieva Tolmane, Hannele Yki-Järvinen, Jörn M. Schattenberg, Juan M. Pericàs, Mattias Mandorfer, Tomislav Bulum, Sanja Musić Milanović, Vibor Šeša, Azina Chara, Malekou Elsa, Georgios A. Pouros, Pari Georgia, Constantinou Nikoletta, Christodoulou Maria, Picolos Michalis, Avraam Thalia, Christodoulides Theodoros, Karel Dvořák, Achim Kautz, Carolin Victoria Schneider, Johannes Wiegand, Cristina Bianco, Stefano Ciardullo, Loreta A. Kondili, Cristina Panico, Serena Pelusi, Gianluca Perseghin, Salvatore Petta, Maria Giovanna Quaranta, Federico Ravaioli, Luca Valenti, Roberto Vettor, Ainis Dzalbs, Anda Kivite-Urtane, Laila Meija, Ivars Tolmanis, Indre Ceponiene, Jonas Ceponis, Indrė Gustaitytė, Povilas Šabanas, Willem Pieter Brouwer, Manuel Castro Cabezas, Joost Drenth, Laurens A. van Kleef, Fabrice MAC. Martens, Jean WM. Muris, R Bart Takkenberg, Maarten E. Tushuizen, Yasaman Vali, Jerzy Jaroszewicz, Dorota Zarębska-Michaluk, Guilherme Duarte, Maria Paula Macedo, Gonçalo Pinto Mendes, Sara Policarpo, Florentina Furtunescu, Corina Silvia Pop, Marek Rac, Borut Jug, Katja Novak, Danica Rotar Pavlič, Rocío Aller, Núria Alonso, Antonio J. Amor, Javier Ampuero, Maria T. Arias-Loste, Jesus M. Banales, Joan Benach, Vanesa Bernal-Monterde, Teresa Broquetas, Maria Buti, Andrea Ciudin, Marta Comas, Javier Crespo, Francisco Javier Cubero, Ana de Hollanda, Moises Diago, Javier Escalada, Núria Fabrellas, Nerea Gomez-Mateos, Concepción Gómez-Gavara, Águeda González-Rodríguez, Jordi Gracia-Sancho, Isabel Graupera, Jordi Hoyo, Luis Ibañez-Samaniego, Marina Idalia Rojo-López, Paula Iruzubieta, Alba Jiménez-Masip, Albert Lecube, Sabela Lens, David Marti-Aguado, Rosa Martín-Mateos, Didac Mauricio, Ana B. Méndez, Juan M. Mendive, Ornella Moreno-Mattar, Rosa M. Morillas, Antonio Olveira, Ángel Ortiz, Laura Pagès, Elisa Pose, Jesús Rivera-Esteban, Diego Rojo, Miguel A. Rubio-Herrera, Zoraida Ruiz, Isabel Serra, Juan Turnes, María Asunción Úbeda Pastor, Mercedes Vergara Gomez, Fredrik Iredahl, Catarina Lindqvist, Johan Vessby, William Alazawi, Matthew J. Armstrong, Amitava Banerjee, Louise Campbell, Kristina Curtis, Eleanor Dow, Kamlesh Khunti, Dina Mansour, Philip N. Newsome, Jeremy W. Tomlinson, Emmanuel Tsochatzis, Andrew Yeoman
Publicado en: The Lancet Regional Health - Europe, Edición 65, 2026, ISSN 2666-7762
Editor: Elsevier BV
DOI: 10.1016/J.LANEPE.2026.101713

A roadmap for clinical trials in MASH-related compensated cirrhosis

Autores: Juan M. Pericàs, Quentin M. Anstee, Salvador Augustin, Ramón Bataller, Annalisa Berzigotti, Andreea Ciudin, Sven Francque, Juan G. Abraldes, Virginia Hernández-Gea, Mònica Pons, Thomas Reiberger, Ian A. Rowe, Peter Rydqvist, Elmer Schabel, Frank Tacke, Emmanuel A. Tsochatzis, Joan Genescà
Publicado en: Nature Reviews Gastroenterology &amp; Hepatology, Edición 21, 2024, ISSN 1759-5045
Editor: Springer Science and Business Media LLC
DOI: 10.1038/S41575-024-00955-8

On the different flavours of practical identifiability

Autores: Mio Heinrich, Rafael Arutjunjan, Jens Timmer
Publicado en: Current Opinion in Systems Biology, Edición 42, 2025, ISSN 2452-3100
Editor: Elsevier BV
DOI: 10.1016/J.COISB.2025.100556

On structural and practical identifiability: Current status and update of results

Autores: Mio Heinrich, Marcus Rosenblatt, Franz-Georg Wieland, Hans Stigter, Jens Timmer
Publicado en: Current Opinion in Systems Biology, Edición 41, 2025, ISSN 2452-3100
Editor: Elsevier BV
DOI: 10.1016/J.COISB.2025.100546

What Can We Learn From Longitudinal Measurements of Liver Stiffness in Metabolic Dysfunction‐Associated Steatotic Liver Disease?

Autores: Stéphanie André‐Dumont, Nicolas Lanthier
Publicado en: Liver International, Edición 46, 2026, ISSN 1478-3223
Editor: Wiley
DOI: 10.1111/LIV.70680

The rate and predictors of recompensation in patients with decompensated cirrhosis due to metabolic dysfunction–associated liver disease (MASLD)

Autores: Alba Jiménez-Masip, M. Teresa Broquetas, Sergio Muñoz-Martinez, Isabel Serra-Matamala, Diego Rojo, Anna Sòria, Cautar El Maimouni, Laura Pagès, Mònica Pons, José A. Carrión, Pere Ginès, Joan Genescà, Isabel Graupera, Juan M. Pericàs
Publicado en: Hepatology Communications, Edición 10, 2026, ISSN 2471-254X
Editor: Ovid Technologies (Wolters Kluwer Health)
DOI: 10.1097/HC9.0000000000000919

A call to action to address the steatotic liver disease public health threat in Barcelona

Autores: Jeffrey V. Lazarus, J. Emilio Miralles-Sanchez, Leire Agirre-Garrido, Nicolai Brachowicz, Aina Nicolàs, Anthony Armenta, Delfina Boudou, Lisa Rice-Duek, Juan M. Pericàs, Joan Benach, Christopher J. Kopka, Dana Ivancovsky Wajcman
Publicado en: The Lancet Regional Health - Europe, Edición 52, 2025, ISSN 2666-7762
Editor: Elsevier BV
DOI: 10.1016/J.LANEPE.2025.101272

Comparison of Bacterial Infections in Patients With Cirrhosis Between Hospitals With and Without Liver Transplant in Catalonia

Autores: Clàudia Torras, Juan Bañares, Aina Martí‐Carretero, Víctor Acin, Laura Pagès, Laura Gutiérrez‐Rios, Antonio Casabella, José Ferrusquía‐Acosta, Jordi Sánchez‐Delgado, Martina Pérez, Diana Fuertes, Marta Garcia‐Guix, Berta Cuyàs, Helena Masnou, Alberto Amador, German Soriano, Juan M. Pericàs, Oriol Gasch, Cristina Solé
Publicado en: Liver International, Edición 45, 2025, ISSN 1478-3223
Editor: Wiley
DOI: 10.1111/LIV.70076

A call to action to address the steatotic liver disease public health threat in Barcelona

Autores: Jeffrey V. Lazarus, J. Emilio Miralles-Sanchez, Leire Agirre-Garrido, Nicolai Brachowicz, Aina Nicolàs, Anthony Armenta, Delfina Boudou, Lisa Rice-Duek, Juan M. Pericàs, Joan Benach, Christopher J. Kopka, Dana Ivancovsky Wajcman
Publicado en: The Lancet Regional Health - Europe, Edición 52, 2025, ISSN 2666-7762
Editor: Elsevier BV
DOI: 10.1016/J.LANEPE.2025.101272

Identifying signatures of image phenotypes to track treatment response in liver disease

Autores: Matthias Perkonigg, Nina Bastati, Ahmed Ba-Ssalamah, Peter Mesenbrink, Alexander Goehler, Miljen Martic, Xiaofei Zhou, Michael Trauner, Georg Langs
Publicado en: Artificial Intelligence in Medicine, Edición 168, 2026, ISSN 0933-3657
Editor: Elsevier BV
DOI: 10.1016/J.ARTMED.2025.103223

Chronic Kidney Disease Does Not Influence Response to Terlipressin in Hepatorenal Syndrome–Acute Kidney Injury

Autores: Frank Erhard Uschner, Eva Maria Schleicher, Moritz Passenberg, Julian Pohl, Michael Praktiknjo, Anna Teresa Volk, Henrik Karbannek, Johannes Chang, Karsten Große, Charlotte Rohrer, Christian Labenz, Benjamin Maasoumy, Paul Jamme, Julian Cardinal von Widdern, Alexander Queck, Jonel Trebicka, Cornelius Engelmann, Jassin Rashidi-Alavijeh, Dominik Bettinger, Cristina Ripoll, Nina Böhling, Maximilian Joseph Brol, Tony Bruns, Marko Damm, Jan Hendrik Harten, Christian Jansen, Christian M. Lange, Lauin Mustafa, Marcus Maximilian Mücke, Sina Oesinghaus, Sarah Schütte, Andreas Stallmach, Christoph Welsch, Alexander Zipprich
Publicado en: Clinical Gastroenterology and Hepatology, Edición 24, 2026, ISSN 1542-3565
Editor: Elsevier BV
DOI: 10.1016/J.CGH.2025.11.006

Disentangling metabolic impairment in the liver-heart axis: tissue-specific insulin sensitivity in type 2 diabetes

Autores: Queralt Martín-Saladich, Andreea Ciudin, Azahara Palomar, Cristina Gámez-Cenzano, Rafael Simó, Miguel A. González Ballester, J. Raul Herance
Publicado en: Frontiers in Endocrinology, Edición 17, 2026, ISSN 1664-2392
Editor: Frontiers Media SA
DOI: 10.3389/FENDO.2026.1786303

EASL postgraduate course report: Vascular biology in chronic liver disease and clinical management implications

Autores: Pierre-Emmanuel Rautou, Ton Lisman, Virginia Hernandez-Gea, Cristina Ripoll
Publicado en: JHEP Reports, Edición 7, 2026, ISSN 2589-5559
Editor: Elsevier BV
DOI: 10.1016/J.JHEPR.2025.101399

Conference proceedings (1)

Disease stage dependent efficacy of systemic apical sodium dependent bile acid transporter (ASBT) inhibition in mice with cholemic nephropathy

Autores: Ahmed Ghallab, Maiju Myllys, Daniela González, Adrian Friebel, Zaynab Hobloss, Reham Hassan, Qasim Siddiqui, Deng Zhipeng, Abdellatief Seddek, Rama Hendawi, Brigitte Begher-Tibbe, Joerg Reinders, Ute Hofmann, Julia Duda, Lucia Ameis, Franziska Kappenberg, Mihael Vucur, Tom Luedde, Matthias Schwab, Mattias Mandorfer, Jörg Rahnenführer, Karolina Edlund, Stefan Hoehme, Michael Trauner, Paul Dawson, Erik Lindström, Jan Hengstler
Publicado en: Zeitschrift für Gastroenterologie, 41. Jahrestagung der Deutschen Arbeitsgemeinschaft zum Studium der Leber, Edición 63, 2025
Editor: Georg Thieme Verlag KG
DOI: 10.1055/S-0044-1801018