AcceleRating the Translation of virtual twins towards a pErsonalised Management of fatty lIver patients

Informazioni relative al progetto

ARTEMIS

ID dell’accordo di sovvenzione: 101136299

DOI

10.3030/101136299

Data della firma CE 7 Dicembre 2023

Data di avvio 1 Gennaio 2024

Data di completamento 31 Dicembre 2027

Finanziato da

• Health

Costo totale

€ 9 365 096,00

Contributo UE

€ 9 365 095,00

Coordinato da

MATICAL INNOVATION SL
Spain

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Documents, reports (7)

ARTEMIs value propostion for the different target groups, learnt from interviews and questionnaires

ARTEMIs value proposition for the different target groups, learnt from interviews and questionnaires.

Ethics guidance report, Ethics Impact Assessment
Description of submodel developments by each model expert
Description of all image processing research activities
Project dissemination and communication plan, including Open Science management and website

Project dissemination and communication plan, including Open Science management and website

Exploitation plan

Initial exploitation plan for the main project outputs.

Record of dissemination and communication actions undertaken in the previous 12 months, and updated plan

Pubblicazioni

Peer reviewed articles (30)

Improving Vessel Segmentation with Multi-Task Learning and Auxiliary Data Available Only During Model Training

Autori: Daniel Sobotka, Alexander Herold, Matthias Perkonigg, Lucian Beer, Nina Bastati, Alina Sablatnig, Ahmed Ba-Ssalamah, Georg Langs
Pubblicato in: Computerized Medical Imaging and Graphics, Numero 114, 2024, ISSN 0895-6111
Editore: Elsevier BV
DOI: 10.1016/J.COMPMEDIMAG.2024.102369

Assessment and management of portal hypertension in patients with MASLD: advances and caveats

Autori: Diego Rojo, Alba Jiménez-Masip, Laura Pagès, Juan Bañares, Clara Sabiote, María Martínez-Gómez, Laia Aceituno, M. Serra Cusidó, M. Teresa Salcedo-Allende, Zyanya Calixto, Mònica Pons, Joan Genescà, Juan M. Pericàs
Pubblicato in: Expert Review of Gastroenterology & Hepatology, 2025, ISSN 1747-4124
Editore: Informa UK Limited
DOI: 10.1080/17474124.2025.2530605

Influence of Low-dose Acetylsalicylic Acid on Renal Function in Patients With Liver Cirrhosis and Ascites

Autori: Henrik Karbannek, Marina Reljic, Andreas Stallmach, Alexander Zipprich, Cristina Ripoll
Pubblicato in: Clinical Gastroenterology and Hepatology, Numero 23, 2025, ISSN 1542-3565
Editore: Elsevier BV
DOI: 10.1016/J.CGH.2025.02.005

A comparative study of lumped heart models for personalized medicine through sensitivity and identifiability analysis

Autori: Marie Haghebaert, Pavlos Varsos, Roel Meiburg, Irene Vignon‐Clementel
Pubblicato in: The Journal of Physiology, 2025, ISSN 0022-3751
Editore: Wiley
DOI: 10.1113/JP287929

Editorial: Three‐Dimensional (<scp>3D</scp>) Geometric Modelling in <scp>TIPS</scp> Implantation—A Further Step Toward Personalised Portal Pressure Reduction?

Autori: Alexander Zipprich, Cristina Ripoll
Pubblicato in: Alimentary Pharmacology &amp; Therapeutics, Numero 62, 2025, ISSN 0269-2813
Editore: Wiley
DOI: 10.1111/APT.70175

Steatotic liver disease and HIV: an agenda for 2030

Autori: Juan M Pericàs, Anish K Arora, Carlotta Riebensahm, Alba Jiménez-Masip, Adrià Ramírez Mena, Trenton M White, Nikos Dedes, Giovanni Guaraldi, Annalisa Berzigotti, Gilles Wandeler, Meena B Bansal, Jordi Navarro, Jeffrey V Lazarus
Pubblicato in: The Lancet HIV, Numero 11, 2024, ISSN 2352-3018
Editore: Elsevier BV
DOI: 10.1016/S2352-3018(24)00097-3

THU-156 Clinical predictors of increased liver stiffness over time in metabolic dysfunction-associated steatotic liver disease: a prospective real-life study

Autori: Stephanie Andre-Dumont, Joyce Scholtens, Nicolas Lanthier
Pubblicato in: Journal of Hepatology, Numero 84, 2026, ISSN 0168-8278
Editore: Elsevier BV
DOI: 10.1016/S0168-8278(26)01554-0

Interaction of inflammation and portal hypertension in cirrhosis progression

Autori: Dalila Costa, Jonel Trebicka, Cristina Ripoll, Richard Moreau, Rajiv Jalan, Thomas Reiberger
Pubblicato in: Nature Reviews Gastroenterology &amp; Hepatology, 2025, ISSN 1759-5045
Editore: Springer Science and Business Media LLC
DOI: 10.1038/S41575-025-01107-2

Diclofenac and acetaminophen dim the acute-phase response but amplify expression of the iron regulator hepcidin in liver cancer cells

Autori: Anja Zeilfelder, Joep Vanlier, Christina Mölders, Philipp Kastl, Barbara Helm, Sebastian Burbano de Lara, Till Möcklinghoff, Nantia Leonidou, Elisa Holstein, Artyom Vlasov, Alexander Held, Silvana Wilken, Katrin Hoffmann, Gerda Schicht, Andrea Scheffschick, Markella Katerinopoulou, Esther Giehl-Brown, Christoph Kahlert, Christoph Michalski, Daniel Seehofer, Georg Damm, Martina U. Muckenthaler, Marcel Schilling, Jens Timmer, Ursula Klingmüller
Pubblicato in: Cell Systems, Numero 16, 2026, ISSN 2405-4712
Editore: Elsevier BV
DOI: 10.1016/J.CELS.2025.101431

Functional liver imaging score (FLIS): A prognostic biomarker for acute-on-chronic liver failure and liver-related mortality

Autori: Sarah Poetter-Lang, Lorenz Balcar, Ahmed Ba-Ssalamah, Nina Bastati, Raphael Ambros, Antonia Kristic, Julia Krawanja, Katharina Pomej, Benedikt Simbrunner, Georg Semmler, Victor Schmidbauer, Svitlana Pochepnia, Daniel Sobotka, Jacqueline C. Hodge, Ulrike Attenberger, Michael Trauner, Thomas Reiberger, Lucian Beer, Mattias Mandorfer
Pubblicato in: JHEP Reports, Numero 8, 2026, ISSN 2589-5559
Editore: Elsevier BV
DOI: 10.1016/J.JHEPR.2026.101928

Interaction of inflammation and portal hypertension in cirrhosis progression

Autori: Dalila Costa, Jonel Trebicka, Cristina Ripoll, Richard Moreau, Rajiv Jalan, Thomas Reiberger
Pubblicato in: Nature Reviews Gastroenterology &amp; Hepatology, Numero 22, 2025, ISSN 1759-5045
Editore: Springer Science and Business Media LLC
DOI: 10.1038/S41575-025-01107-2

Influence of Low-dose Acetylsalicylic Acid on Renal Function in Patients With Liver Cirrhosis and Ascites

Autori: Henrik Karbannek, Marina Reljic, Andreas Stallmach, Alexander Zipprich, Cristina Ripoll
Pubblicato in: Clinical Gastroenterology and Hepatology, Numero 23, 2025, ISSN 1542-3565
Editore: Elsevier BV
DOI: 10.1016/J.CGH.2025.02.005

Editorial: Three‐Dimensional (<scp>3D</scp>) Geometric Modelling in <scp>TIPS</scp> Implantation—A Further Step Toward Personalised Portal Pressure Reduction?

Autori: Alexander Zipprich, Cristina Ripoll
Pubblicato in: Alimentary Pharmacology &amp; Therapeutics, Numero 62, 2025, ISSN 0269-2813
Editore: Wiley
DOI: 10.1111/APT.70175

Correlation between MRI-derived and biopsy-confirmed liver iron concentration in patients with chronic liver disease

Autori: Sami A. Ba-Ssalamah, Michael Schwarz, Sarah Poetter-Lang, Nina Bastati, Ahmet Y. Yitik, Jacqueline C. Hodge, Lucian Beer, Nicolas Balutsch, Albert Friedrich Stättermayer, Michael Trauner, Mattias Mandorfer, Ahmed Ba-Ssalamah, Georg Langs, Benjamin Henninger, Yves Gandon, Ulrike Attenberger, Lukas Haider, Thomas Reiberger
Pubblicato in: European Journal of Radiology, Numero 194, 2026, ISSN 0720-048X
Editore: Elsevier BV
DOI: 10.1016/J.EJRAD.2025.112484

On the different flavours of practical identifiability

Autori: Mio Heinrich, Rafael Arutjunjan, Jens Timmer
Pubblicato in: Current Opinion in Systems Biology, Numero 42, 2026, ISSN 2452-3100
Editore: Elsevier BV
DOI: 10.1016/J.COISB.2025.100556

Cost of Metabolic Dysfunction‐Associated Steatotic Liver Disease Screening Among All People Living With Diabetes in Six Countries

Autori: Jeffrey V. Lazarus, Leire Agirre‐Garrido, J. Emilio Miralles‐Sanchez, Melina I. Manolas, Frank Tacke, Cristiane A. Villela‐Nogueira, Hussain Abdulrahman Al‐Omar, Saleh A. Alqahtani, Lamya Mohammed Yahya Alzubaidi, Meena Bansal, Kenneth Cusi, Scott D. Isaacs, Didac Mauricio, Teruki Miyake, Rodrigo O. Moreira, Shoko Nakazawa, Silvana Pannain, Juan M. Pericàs, Michael Roden, Hirokazu Takahashi, Nicolai Brachowicz
Pubblicato in: Liver International, Numero 45, 2026, ISSN 1478-3223
Editore: Wiley
DOI: 10.1111/LIV.70390

MRI-derived quantification of hepatic vessel-to-volume ratios in chronic liver disease using a deep learning approach

Autori: Alexander Herold, Daniel Sobotka, Lucian Beer, Nina Bastati, Sarah Poetter-Lang, Michael Weber, Thomas Reiberger, Mattias Mandorfer, Georg Semmler, Benedikt Simbrunner, Barbara D. Wichtmann, Sami A. Ba-Ssalamah, Michael Trauner, Ahmed Ba-Ssalamah, Georg Langs
Pubblicato in: European Radiology Experimental, Numero 9, 2025, ISSN 2509-9280
Editore: Springer Science and Business Media LLC
DOI: 10.1186/S41747-025-00612-Y

Assessing Europe's policy readiness to confront the MASLD/MASH public health threat

Autori: Jeffrey V. Lazarus, Trenton M. White, Leire Agirre-Garrido, Kushala W.M. Abeysekera, Paul N. Brennan, Radan Brůha, Stefan Buttigieg, Patrizia Carrieri, Helena Cortez-Pinto, Robert Flisiak, Sven M.A. Francque, Gema Frühbeck, Liliana Simona Gheorghe, Hannes Hagström, Adriaan G. Holleboom, Krasen Ivanov, Mojca Jensterle, Peter Jepsen, Juozas Kupčinskas, Henry E. Mark, Didac Mauricio, Saba Mohamed Bibi, Christophe Moreno, Anna Mrzljak, Eleni Papanicolaou, Maria Papp, Georgios Papatheodoridis, Markus Peck-Radosavljevic, Nicola Pugliese, John D. Ryan, Rogério T. Ribeiro, Riina Salupere, Lubomir Skladany, Ieva Tolmane, Hannele Yki-Järvinen, Jörn M. Schattenberg, Juan M. Pericàs, Mattias Mandorfer, Tomislav Bulum, Sanja Musić Milanović, Vibor Šeša, Azina Chara, Malekou Elsa, Georgios A. Pouros, Pari Georgia, Constantinou Nikoletta, Christodoulou Maria, Picolos Michalis, Avraam Thalia, Christodoulides Theodoros, Karel Dvořák, Achim Kautz, Carolin Victoria Schneider, Johannes Wiegand, Cristina Bianco, Stefano Ciardullo, Loreta A. Kondili, Cristina Panico, Serena Pelusi, Gianluca Perseghin, Salvatore Petta, Maria Giovanna Quaranta, Federico Ravaioli, Luca Valenti, Roberto Vettor, Ainis Dzalbs, Anda Kivite-Urtane, Laila Meija, Ivars Tolmanis, Indre Ceponiene, Jonas Ceponis, Indrė Gustaitytė, Povilas Šabanas, Willem Pieter Brouwer, Manuel Castro Cabezas, Joost Drenth, Laurens A. van Kleef, Fabrice MAC. Martens, Jean WM. Muris, R Bart Takkenberg, Maarten E. Tushuizen, Yasaman Vali, Jerzy Jaroszewicz, Dorota Zarębska-Michaluk, Guilherme Duarte, Maria Paula Macedo, Gonçalo Pinto Mendes, Sara Policarpo, Florentina Furtunescu, Corina Silvia Pop, Marek Rac, Borut Jug, Katja Novak, Danica Rotar Pavlič, Rocío Aller, Núria Alonso, Antonio J. Amor, Javier Ampuero, Maria T. Arias-Loste, Jesus M. Banales, Joan Benach, Vanesa Bernal-Monterde, Teresa Broquetas, Maria Buti, Andrea Ciudin, Marta Comas, Javier Crespo, Francisco Javier Cubero, Ana de Hollanda, Moises Diago, Javier Escalada, Núria Fabrellas, Nerea Gomez-Mateos, Concepción Gómez-Gavara, Águeda González-Rodríguez, Jordi Gracia-Sancho, Isabel Graupera, Jordi Hoyo, Luis Ibañez-Samaniego, Marina Idalia Rojo-López, Paula Iruzubieta, Alba Jiménez-Masip, Albert Lecube, Sabela Lens, David Marti-Aguado, Rosa Martín-Mateos, Didac Mauricio, Ana B. Méndez, Juan M. Mendive, Ornella Moreno-Mattar, Rosa M. Morillas, Antonio Olveira, Ángel Ortiz, Laura Pagès, Elisa Pose, Jesús Rivera-Esteban, Diego Rojo, Miguel A. Rubio-Herrera, Zoraida Ruiz, Isabel Serra, Juan Turnes, María Asunción Úbeda Pastor, Mercedes Vergara Gomez, Fredrik Iredahl, Catarina Lindqvist, Johan Vessby, William Alazawi, Matthew J. Armstrong, Amitava Banerjee, Louise Campbell, Kristina Curtis, Eleanor Dow, Kamlesh Khunti, Dina Mansour, Philip N. Newsome, Jeremy W. Tomlinson, Emmanuel Tsochatzis, Andrew Yeoman
Pubblicato in: The Lancet Regional Health - Europe, Numero 65, 2026, ISSN 2666-7762
Editore: Elsevier BV
DOI: 10.1016/J.LANEPE.2026.101713

A roadmap for clinical trials in MASH-related compensated cirrhosis

Autori: Juan M. Pericàs, Quentin M. Anstee, Salvador Augustin, Ramón Bataller, Annalisa Berzigotti, Andreea Ciudin, Sven Francque, Juan G. Abraldes, Virginia Hernández-Gea, Mònica Pons, Thomas Reiberger, Ian A. Rowe, Peter Rydqvist, Elmer Schabel, Frank Tacke, Emmanuel A. Tsochatzis, Joan Genescà
Pubblicato in: Nature Reviews Gastroenterology &amp; Hepatology, Numero 21, 2024, ISSN 1759-5045
Editore: Springer Science and Business Media LLC
DOI: 10.1038/S41575-024-00955-8

On the different flavours of practical identifiability

Autori: Mio Heinrich, Rafael Arutjunjan, Jens Timmer
Pubblicato in: Current Opinion in Systems Biology, Numero 42, 2025, ISSN 2452-3100
Editore: Elsevier BV
DOI: 10.1016/J.COISB.2025.100556

On structural and practical identifiability: Current status and update of results

Autori: Mio Heinrich, Marcus Rosenblatt, Franz-Georg Wieland, Hans Stigter, Jens Timmer
Pubblicato in: Current Opinion in Systems Biology, Numero 41, 2025, ISSN 2452-3100
Editore: Elsevier BV
DOI: 10.1016/J.COISB.2025.100546

What Can We Learn From Longitudinal Measurements of Liver Stiffness in Metabolic Dysfunction‐Associated Steatotic Liver Disease?

Autori: Stéphanie André‐Dumont, Nicolas Lanthier
Pubblicato in: Liver International, Numero 46, 2026, ISSN 1478-3223
Editore: Wiley
DOI: 10.1111/LIV.70680

The rate and predictors of recompensation in patients with decompensated cirrhosis due to metabolic dysfunction–associated liver disease (MASLD)

Autori: Alba Jiménez-Masip, M. Teresa Broquetas, Sergio Muñoz-Martinez, Isabel Serra-Matamala, Diego Rojo, Anna Sòria, Cautar El Maimouni, Laura Pagès, Mònica Pons, José A. Carrión, Pere Ginès, Joan Genescà, Isabel Graupera, Juan M. Pericàs
Pubblicato in: Hepatology Communications, Numero 10, 2026, ISSN 2471-254X
Editore: Ovid Technologies (Wolters Kluwer Health)
DOI: 10.1097/HC9.0000000000000919

A call to action to address the steatotic liver disease public health threat in Barcelona

Autori: Jeffrey V. Lazarus, J. Emilio Miralles-Sanchez, Leire Agirre-Garrido, Nicolai Brachowicz, Aina Nicolàs, Anthony Armenta, Delfina Boudou, Lisa Rice-Duek, Juan M. Pericàs, Joan Benach, Christopher J. Kopka, Dana Ivancovsky Wajcman
Pubblicato in: The Lancet Regional Health - Europe, Numero 52, 2025, ISSN 2666-7762
Editore: Elsevier BV
DOI: 10.1016/J.LANEPE.2025.101272

Comparison of Bacterial Infections in Patients With Cirrhosis Between Hospitals With and Without Liver Transplant in Catalonia

Autori: Clàudia Torras, Juan Bañares, Aina Martí‐Carretero, Víctor Acin, Laura Pagès, Laura Gutiérrez‐Rios, Antonio Casabella, José Ferrusquía‐Acosta, Jordi Sánchez‐Delgado, Martina Pérez, Diana Fuertes, Marta Garcia‐Guix, Berta Cuyàs, Helena Masnou, Alberto Amador, German Soriano, Juan M. Pericàs, Oriol Gasch, Cristina Solé
Pubblicato in: Liver International, Numero 45, 2025, ISSN 1478-3223
Editore: Wiley
DOI: 10.1111/LIV.70076

A call to action to address the steatotic liver disease public health threat in Barcelona

Autori: Jeffrey V. Lazarus, J. Emilio Miralles-Sanchez, Leire Agirre-Garrido, Nicolai Brachowicz, Aina Nicolàs, Anthony Armenta, Delfina Boudou, Lisa Rice-Duek, Juan M. Pericàs, Joan Benach, Christopher J. Kopka, Dana Ivancovsky Wajcman
Pubblicato in: The Lancet Regional Health - Europe, Numero 52, 2025, ISSN 2666-7762
Editore: Elsevier BV
DOI: 10.1016/J.LANEPE.2025.101272

Identifying signatures of image phenotypes to track treatment response in liver disease

Autori: Matthias Perkonigg, Nina Bastati, Ahmed Ba-Ssalamah, Peter Mesenbrink, Alexander Goehler, Miljen Martic, Xiaofei Zhou, Michael Trauner, Georg Langs
Pubblicato in: Artificial Intelligence in Medicine, Numero 168, 2026, ISSN 0933-3657
Editore: Elsevier BV
DOI: 10.1016/J.ARTMED.2025.103223

Chronic Kidney Disease Does Not Influence Response to Terlipressin in Hepatorenal Syndrome–Acute Kidney Injury

Autori: Frank Erhard Uschner, Eva Maria Schleicher, Moritz Passenberg, Julian Pohl, Michael Praktiknjo, Anna Teresa Volk, Henrik Karbannek, Johannes Chang, Karsten Große, Charlotte Rohrer, Christian Labenz, Benjamin Maasoumy, Paul Jamme, Julian Cardinal von Widdern, Alexander Queck, Jonel Trebicka, Cornelius Engelmann, Jassin Rashidi-Alavijeh, Dominik Bettinger, Cristina Ripoll, Nina Böhling, Maximilian Joseph Brol, Tony Bruns, Marko Damm, Jan Hendrik Harten, Christian Jansen, Christian M. Lange, Lauin Mustafa, Marcus Maximilian Mücke, Sina Oesinghaus, Sarah Schütte, Andreas Stallmach, Christoph Welsch, Alexander Zipprich
Pubblicato in: Clinical Gastroenterology and Hepatology, Numero 24, 2026, ISSN 1542-3565
Editore: Elsevier BV
DOI: 10.1016/J.CGH.2025.11.006

Disentangling metabolic impairment in the liver-heart axis: tissue-specific insulin sensitivity in type 2 diabetes

Autori: Queralt Martín-Saladich, Andreea Ciudin, Azahara Palomar, Cristina Gámez-Cenzano, Rafael Simó, Miguel A. González Ballester, J. Raul Herance
Pubblicato in: Frontiers in Endocrinology, Numero 17, 2026, ISSN 1664-2392
Editore: Frontiers Media SA
DOI: 10.3389/FENDO.2026.1786303

EASL postgraduate course report: Vascular biology in chronic liver disease and clinical management implications

Autori: Pierre-Emmanuel Rautou, Ton Lisman, Virginia Hernandez-Gea, Cristina Ripoll
Pubblicato in: JHEP Reports, Numero 7, 2026, ISSN 2589-5559
Editore: Elsevier BV
DOI: 10.1016/J.JHEPR.2025.101399

Conference proceedings (1)

Disease stage dependent efficacy of systemic apical sodium dependent bile acid transporter (ASBT) inhibition in mice with cholemic nephropathy

Autori: Ahmed Ghallab, Maiju Myllys, Daniela González, Adrian Friebel, Zaynab Hobloss, Reham Hassan, Qasim Siddiqui, Deng Zhipeng, Abdellatief Seddek, Rama Hendawi, Brigitte Begher-Tibbe, Joerg Reinders, Ute Hofmann, Julia Duda, Lucia Ameis, Franziska Kappenberg, Mihael Vucur, Tom Luedde, Matthias Schwab, Mattias Mandorfer, Jörg Rahnenführer, Karolina Edlund, Stefan Hoehme, Michael Trauner, Paul Dawson, Erik Lindström, Jan Hengstler
Pubblicato in: Zeitschrift für Gastroenterologie, 41. Jahrestagung der Deutschen Arbeitsgemeinschaft zum Studium der Leber, Numero 63, 2025
Editore: Georg Thieme Verlag KG
DOI: 10.1055/S-0044-1801018