Description du projet
Une nouvelle plateforme vaccinale pour protéger les porcs
La peste porcine africaine (PPA) menace les populations de porcs et de sangliers de toute l’Europe. La maladie, causée par le virus de la PPA (VPPA), pose de graves problèmes liés à ses diverses variantes et à l’efficacité limitée des vaccins traditionnels. Les mesures actuelles peinent à contenir les foyers de PPA, ce qui entraîne des pertes économiques et soulève des préoccupations relatives au bien-être animal. Dans ce contexte, le projet VAX4ASF, financé par l’UE, se propose de fournir une solution définitive, efficace et sûre pour lutter contre le VPPA, qui est hautement contagieux, imprévisible et complexe. Le projet entend innover en s’appuyant sur des approches et des stratégies de vaccination antérieures susceptibles de porter leurs fruits. Il propose par ailleurs de nouveaux modèles d’épidémiologie virale et de nouvelles stratégies de contrôle, favorisant une meilleure compréhension de la transmission.
Objectif
VAX4ASF aims to develop a state-of-the-art platform to produce highly effective and safe vaccines against ASFV targeted for both domestic pigs and wild boars. These vaccine candidates will be designed based on an innovative and robust vaccine platform that will guarantee immune protection against the different circulating ASFV variants in Europe, while avoiding the safety concerns arisen with the use of traditional live attenuated vaccine platforms. Vaccine candidates will effectively induce innate immune response with the adequate adaptive immunity. Moreover, the immunity induced will allow discrimination between vaccinated and infected animals, which will be monitored by complementary DIVA tests developed under the scope of the project. Given the complexity of ASFV genome and the still incomplete knowledge of the mechanisms involved in immune response to ASFV, VAX4ASF aims to further understand the molecular mechanisms of the virus and how it interacts with the host. The developed platform can be used to introduce new mutations based in this new generated knowledge which will allow to improve the efficacy and cross-protection of the vaccine prototypes.
VAX4ASF will provide new virus epidemiology models and control strategies using different mathematical models, leading to a better understanding of the ASFV transmission at the wild-domestic interface. In this way, innovative policies and strategies for ASFV control and management will be generated to ensure an outstanding impact through the continuous involvement of key stakeholders as project partners (farmers, wild board managers, veterinaries, hunters, policy makers...) leading to a profound effect in animal health and worldwide economy. The project relies on a solid collaboration trajectory between leading developers of innovative Animal Health vaccines and the highest experts in ASF field at international level, including partners from Europe, USA, and Kenya for the achievement of this challenge.
Champ scientifique
- natural sciencesbiological sciencesmicrobiologyvirology
- medical and health scienceshealth sciencespublic healthepidemiology
- medical and health sciencesbasic medicineimmunology
- medical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsvaccines
- natural sciencesmathematicsapplied mathematicsmathematical model
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HORIZON-RIA - HORIZON Research and Innovation ActionsCoordinateur
17170 Amer Girona
Espagne