Descripción del proyecto
Una nueva plataforma de vacunas para mantener la seguridad de los cerdos
La peste porcina africana (PPA o ASF, por sus siglas en inglés) amenaza a las poblaciones de cerdos y jabalíes de Europa. La enfermedad, que está provocada por el virus de la PPA (VPPA), plantea importantes problemas debido a sus variantes y a la limitada eficacia de las vacunas tradicionales. Las medidas actuales no logran contener los brotes de PPA, lo cual conlleva pérdidas económicas e importantes problemas de bienestar animal. En este contexto, el proyecto VAX4ASF, financiado con fondos europeos, tiene por objeto ofrecer una solución definitiva, eficaz y segura contra el VPPA, un microorganismo muy contagioso, impredecible y complejo. Su equipo se propone innovar en este campo capitalizando métodos y estrategias de vacunación previos con potencial de éxito. Además, desarrollará nuevos modelos epidemiológicos y estrategias de control del virus que contribuyan a comprender mejor su transmisión.
Objetivo
VAX4ASF aims to develop a state-of-the-art platform to produce highly effective and safe vaccines against ASFV targeted for both domestic pigs and wild boars. These vaccine candidates will be designed based on an innovative and robust vaccine platform that will guarantee immune protection against the different circulating ASFV variants in Europe, while avoiding the safety concerns arisen with the use of traditional live attenuated vaccine platforms. Vaccine candidates will effectively induce innate immune response with the adequate adaptive immunity. Moreover, the immunity induced will allow discrimination between vaccinated and infected animals, which will be monitored by complementary DIVA tests developed under the scope of the project. Given the complexity of ASFV genome and the still incomplete knowledge of the mechanisms involved in immune response to ASFV, VAX4ASF aims to further understand the molecular mechanisms of the virus and how it interacts with the host. The developed platform can be used to introduce new mutations based in this new generated knowledge which will allow to improve the efficacy and cross-protection of the vaccine prototypes.
VAX4ASF will provide new virus epidemiology models and control strategies using different mathematical models, leading to a better understanding of the ASFV transmission at the wild-domestic interface. In this way, innovative policies and strategies for ASFV control and management will be generated to ensure an outstanding impact through the continuous involvement of key stakeholders as project partners (farmers, wild board managers, veterinaries, hunters, policy makers...) leading to a profound effect in animal health and worldwide economy. The project relies on a solid collaboration trajectory between leading developers of innovative Animal Health vaccines and the highest experts in ASF field at international level, including partners from Europe, USA, and Kenya for the achievement of this challenge.
Ámbito científico
- natural sciencesbiological sciencesmicrobiologyvirology
- medical and health scienceshealth sciencespublic healthepidemiology
- medical and health sciencesbasic medicineimmunology
- medical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsvaccines
- natural sciencesmathematicsapplied mathematicsmathematical model
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