VIrtual Twins as tools for personalised clinicAL care

Project Information

VITAL

Grant agreement ID: 101136728

DOI

10.3030/101136728

EC signature date 10 November 2023

Start date 1 January 2024

End date 31 December 2028

Funded under

• Health

Total cost

€ 8 743 516,25

EU contribution

€ 8 743 516,25

Coordinated by

UNIVERSITEIT GENT
Belgium

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Websites, patent fillings, videos etc. (3)

Dissemination and communication plan

Dissemination and communication plan (T8.1).

Launch of project web-site

Launch of project web-site and setting up media channels (T8.2).

Dedicated templates, posters, brochures with the project logo and infographics

Dedicated templates, posters, brochures with the project logo and infographics (T8.4).

Documents, reports (2)

Project Management Handbook

Project Management Handbook describing the project management, risk management and quality assurance procedures and including templates for progress and financial reporting (T1.1).

Initial Sustainability and Exploitation plan

First version of an exploitation plan for the VITAL project (T7.6).

Other (1)

First Technical hands-on modelling training school

First Technical hands-on modelling training school (T8.3).

Data Management Plan (1)

Data Management Plan

First version of the Data Management Plan: Data Management Plan outlines how data will be collected/handled/stored according to the FAIR principles (T1.3).

Publications

Conference proceedings (7)

Action potential encoding for efficient axon propogation computation

Author(s): James Zeng, Gonzalo Maso Talou, Finbar Argus
Publisher: CMBE 2026 Proceedings

MRI-informed haemodynamic modelling for noninvasive characterisation of cerebrovascular stiffness

Author(s): B. Ghitti, S. Dempsey, A. Sharifzadeh-Kermani, F. Argus, and G. Maso Talou
Publisher: CMBE 2026 Proceedings

Large deformation diffeomorphic cardiac strain mapping

Author(s): Moscoloni B, Segers P, Peirlinck M
Publisher: ArXiv
DOI: 10.48550/ARXIV.2504.03291

Network-level hemodynamic consequences of pericyte-induced capillary stalls in skeletal muscle microvasculature

Author(s): S. Liu, G. Maso Talou, B. Ghitti, H. Davis, and F. Argus
Publisher: CMBE2026 Proceedings

A Computational Model of the Sympathetic Neuron for Drug Treatment Investigation in Sympathetic Hyperactivity

Author(s): Finbar John Argus
Published in: Computing in Cardiology Conference (CinC), 2024 Computing in Cardiology Conference (CinC), Issue 51, 2024
Publisher: Computing in Cardiology
DOI: 10.22489/CINC.2024.142

Speeding up the computational time of biological models via automatic mathematical conversion

Author(s): R. Lee, A. Garny, and F. Argus
Publisher: CMBE 2026 Proceedings

GROWTH AND REMODELLING OF THE FEMORAL ARTERY IN RESPONSE TO SIMULATED MICROGRAVITY: IN VIVO ANALYSIS

Author(s): Alessandro Giudici1, Shaiv Parikh2, Karen Barchetti3, Umit Gencer3,4, Hakim Khettab3,4, Elie Mousseaux3,4, Carole Leguy5, Tammo Delhaas1, Rosa Maria Bruno3, Pierre Boutouyrie3,4, and Bart Spronck
Publisher: CMBE2026
DOI: 10.5281/ZENODO.21775715

Peer reviewed articles (21)

Unveiling sex dimorphism in the healthy cardiac anatomy: Fundamental differences between male and female heart shapes

Author(s): Beatrice Moscoloni, Cameron Beeche, Julio A. Chirinos, Patrick Segers, Mathias Peirlinck
Published in: The Journal of Physiology, Issue 604, 2026, ISSN 0022-3751
Publisher: Wiley
DOI: 10.1113/JP288667

Energy-based bond graph models of glucose transport with SLC transporters

Author(s): Peter J. Hunter, Weiwei Ai, David P. Nickerson
Published in: Biophysical Journal, Issue 124, 2025, ISSN 0006-3495
Publisher: Elsevier BV
DOI: 10.5281/zenodo.15100941

Impact of Dynamic Axial Stretching on the Arterial Pulse Wave Velocity: Physical Foundation and Clinical Implications

Author(s): Shaiv Parikh, Koen D. Reesink, Bart Spronck, Tammo Delhaas, Alessandro Giudici
Published in: Annals of Biomedical Engineering, Issue 54, 2026, ISSN 0090-6964
Publisher: Springer Science and Business Media LLC
DOI: 10.1007/S10439-025-03940-7

Instability in Computational Models of Vascular Smooth Muscle Cell Contraction

Author(s): Alessandro Giudici, Jason M. Szafron, Abhay B. Ramachandra, Bart Spronck
Published in: Annals of Biomedical Engineering, Issue 52, 2024, ISSN 0090-6964
Publisher: Springer Science and Business Media LLC
DOI: 10.1007/s10439-024-03532-x

Non-invasive evaluation of the hemodynamic significance of renal artery stenosis in fibromuscular dysplasia through quantitative image analysis

Author(s): Alessandro Giudici, Tom Robberechts, Jacek Kądziela, Maria S Stoenoiu, Philippe Delmotte, Kim M Donkers, Jojanne E Van Leeuwen, Laurent Toubiana, Andrzej Januszewicz, Magda Januszewicz, Alexandre Persu, Bart Spronck
Published in: Polish Heart Journal, Issue 84, 2026, ISSN 1897-4279
Publisher: Polskie Towarzystwo Kardiologiczne
DOI: 10.33963/V.PHJ.108870

Assessing vascular health by measuring arterial stiffness in response to hemodynamic load

Author(s): Sanam Khataei, Kaveh Jafari, Catherine Fortier, Emy Philibert, Elizabeth de Rico, Bart Spronck, Alessandro Guidici, Hasan Obeid, Saliha Addour, Emmanuel Bujold, Rémi Goupil, Mohsen Agharazii
Published in: Journal of Hypertension, Issue 44, 2026, ISSN 0263-6352
Publisher: Ovid Technologies (Wolters Kluwer Health)
DOI: 10.1097/HJH.0000000000004230

A Constitutive Modelling Outlook on Arterial (dys)function: Bridging the Gap with the Clinic

Author(s): A. Giudici
Published in: Artery Research, Issue 32, 2026, ISSN 1876-4401
Publisher: Springer Science and Business Media LLC
DOI: 10.1007/S44200-026-00116-Z

The role of vascular smooth muscle cell plasticity in arterial remodelling and biomechanical failure: a numerical approach

Author(s): Yousof M. A. Abdel-Raouf, Lauranne Maes, Ludovica Maga, Julie De Backer, Patrick Sips, Mathias Peirlinck, Nele Famaey, Jay D. Humphrey, Patrick Segers
Published in: Proceedings of the Royal Society A Mathematical Physical and Engineering Science, Issue 482, 2026, ISSN 1364-5021
Publisher: The Royal Society
DOI: 10.1098/RSPA.2025.0787

Human Aortic Vasoreactivity in Response to Various Stimuli: A Review

Author(s): Cindy van Loo, Stan M.R.L. Toonen, Leon J. Schurgers, Tammo Delhaas, Bart Spronck
Published in: Pulse, Issue 13, 2025, ISSN 2235-8676
Publisher: S. Karger AG
DOI: 10.1159/000547617

Vascular aging impairs active modulation of murine aortic stiffness by smooth muscle cells

Author(s): Koen W. F. van der Laan, Cédric H. G. Neutel, Margarita G. Pencheva, Callan D. Wesley, Dustin N. Krüger, Casper G. Schalkwijk, Guido R. Y. De Meyer, Wim Martinet, Koen D. Reesink, Tammo Delhaas, Alessandro Giudici, Pieter-Jan Guns, Bart Spronck
Published in: American Journal of Physiology-Cell Physiology, Issue 329, 2025, ISSN 0363-6143
Publisher: American Physiological Society
DOI: 10.1152/AJPCELL.00387.2025

Full-field surrogate modeling of cardiac electrophysiology encoding geometric variability

Author(s): Elena Sabdy Martinez, Beatrice Moscoloni, Matteo Salvador, Fanwei Kong, Mathias Peirlinck, Alison Lesley Marsden
Published in: Computer Methods in Applied Mechanics and Engineering, Issue 448, 2026, ISSN 0045-7825
Publisher: Elsevier BV
DOI: 10.1016/J.CMA.2025.118444

Biaxial biomechanics of aged human carotid arteries

Author(s): Cindy van Loo, Kailey A. Stevens, Taisiya Sigaeva, Alessandro Giudici, Leon J. Schurgers, Tammo Delhaas, Jason S. Au, Bart Spronck
Published in: Journal of the Mechanical Behavior of Biomedical Materials, Issue 182, 2026, ISSN 1751-6161
Publisher: Elsevier BV
DOI: 10.1016/J.JMBBM.2026.107529

Accounting for approximation errors using surrogate-based parameter estimation of cardiac mechanics digital twins

Author(s): F. Argus, S.A. Creamer, R. Nicholson, O.J. Maclaren, G.D. Maso Talou, V.Y. Wang, D. Zhao, A.A. Young, M.P. Nash, T.P. Babarenda Gamage
Published in: Computer Methods and Programs in Biomedicine, Issue 285, 2026, ISSN 0169-2607
Publisher: Elsevier BV
DOI: 10.1016/J.CMPB.2026.109528

Anxiety and depression in cardiac amyloidosis: a systematic review

Author(s): Simon Ghinassi, Lucia Ponti, Martina Smorti, Francesco Cappelli
Published in: BMJ Open, Issue 15, 2025, ISSN 2044-6055
Publisher: BMJ
DOI: 10.1136/BMJOPEN-2024-094614

The Physiome Project and Digital Twins

Author(s): P. Hunter, B. de Bono, D. Brooks, R. Christie, J. Hussan, M. Lin, and D. Nickerso
Published in: IEEE Reviews in Biomedical Engineering, ISSN 3950-4298
Publisher: IEEE
DOI: 10.5281/ZENODO.15100982

Phenomenological model of transthyretin stabilization

Author(s): Bartek Lisowski, Seweryn Ulaszek, Barbara Wiśniowska, Veronika Bernhauerová, Sebastian Polak
Published in: Scientific Reports, Issue 16, 2026, ISSN 2045-2322
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/S41598-026-35000-Y

A software benchmark for cardiac elastodynamics

Author(s): Reidmen Aróstica, David Nolte, Aaron Brown, Amadeus Gebauer, Elias Karabelas, Javiera Jilberto, Matteo Salvador, Michele Bucelli, Roberto Piersanti, Kasra Osouli, Christoph Augustin, Henrik Finsberg, Lei Shi, Marc Hirschvogel, Martin Pfaller, Pasquale Claudio Africa, Matthias Gsell, Alison Marsden, David Nordsletten, Francesco Regazzoni, Gernot Plank, Joakim Sundnes, Luca Dede’, Mathias Peirlinck, Vijay Vedula, Wolfgang Wall, Cristóbal Bertoglio
Published in: Computer Methods in Applied Mechanics and Engineering, Issue 435, 2025, ISSN 0045-7825
Publisher: Elsevier BV
DOI: 10.5281/ZENODO.15100768

Machine learning-enabled estimation of cardiac output from peripheral waveforms is independent of blood pressure measurement location in an in silico population

Author(s): Lydia Aslanidou, Georgios Rovas, Ramin Mohammadi, Sokratis Anagnostopoulos, Cemre Çelikbudak Orhon, Nikolaos Stergiopulos
Published in: Scientific Reports, Issue 15, 2025, ISSN 2045-2322
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/S41598-025-10492-2

Vasoactive Response of the Thoracic Aorta to Phenylephrine Infusion During Cardiac Surgery

Author(s): Stan M.R.L. Toonen, Frederique M. de Raat, Cindy van Loo, Luuk van Knippenberg, Joris van Houte, Tammo Delhaas, Leon J. Schurgers, Ana Jerončić, Massimo Mischi, R. Arthur Bouwman, Leon J. Montenij, Bart Spronck
Published in: Journal of Applied Physiology, 2026, ISSN 8750-7587
Publisher: American Physiological Society
DOI: 10.1152/JAPPLPHYSIOL.00996.2025

Exploring Tafamidis Effects Through PBPK–QSP Modelling

Author(s): Seweryn Ulaszek, Bartek Lisowski, Barbara Wiśniowska, Sebastian Polak
Published in: Pharmaceutics, Issue 18, 2026, ISSN 1999-4923
Publisher: MDPI AG
DOI: 10.3390/PHARMACEUTICS18030367

Significance of Dynamic Axial Stretching on Estimating Biomechanical Behavior and Properties of the Human Ascending Aorta

Author(s): Shaiv Parikh, Alessandro Giudici, Wouter Huberts, Tammo Delhaas, Elham Bidar, Bart Spronck, Koen Reesink
Published in: Annals of Biomedical Engineering, Issue 52, 2024, ISSN 0090-6964
Publisher: Springer Science and Business Media LLC
DOI: 10.5281/zenodo.15100877

Other (3)

Understanding the interplay of collagen and myocyte adaptation in cardiac volume overload: a multi-constituent growth and remodeling framework.

Author(s): Maga L, Peirlinck M, Noel L
Publisher: arXiv
DOI: 10.48550/ARXIV.2510.11670

Fast and Accurate Inverse Blood Flow Modeling from Minimal Cuff-Pressure Data via PINNs

Author(s): Aslanidou L, Rovas G, Mohammadi R, Anagnostopoulos S, Celikbudak Orhon C., Stergiopulos N.
Publisher: ArXiv

Flow-based conditional cardiac anatomy generation for virtual cohorts

Author(s): Konstantinos Kevopoulos, Beatrice Moscoloni, Benjamin Alheit, Cameron Beeche, Julio A. Chirinos, Alexander Heinlein, Mathias Peirlinck
Publisher: ArXiv
DOI: 10.48550/ARXIV.2608.09460