VIrtual Twins as tools for personalised clinicAL care

Informazioni relative al progetto

VITAL

ID dell’accordo di sovvenzione: 101136728

DOI

10.3030/101136728

Data della firma CE 10 Novembre 2023

Data di avvio 1 Gennaio 2024

Data di completamento 31 Dicembre 2028

Finanziato da

• Health

Costo totale

€ 8 743 516,25

Contributo UE

€ 8 743 516,25

Coordinato da

UNIVERSITEIT GENT
Belgium

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Websites, patent fillings, videos etc. (3)

Dissemination and communication plan

Dissemination and communication plan (T8.1).

Launch of project web-site

Launch of project web-site and setting up media channels (T8.2).

Dedicated templates, posters, brochures with the project logo and infographics

Dedicated templates, posters, brochures with the project logo and infographics (T8.4).

Documents, reports (2)

Project Management Handbook

Project Management Handbook describing the project management, risk management and quality assurance procedures and including templates for progress and financial reporting (T1.1).

Initial Sustainability and Exploitation plan

First version of an exploitation plan for the VITAL project (T7.6).

Other (1)

First Technical hands-on modelling training school

First Technical hands-on modelling training school (T8.3).

Data Management Plan (1)

Data Management Plan

First version of the Data Management Plan: Data Management Plan outlines how data will be collected/handled/stored according to the FAIR principles (T1.3).

Pubblicazioni

Conference proceedings (7)

Action potential encoding for efficient axon propogation computation

Autori: James Zeng, Gonzalo Maso Talou, Finbar Argus
Editore: CMBE 2026 Proceedings

MRI-informed haemodynamic modelling for noninvasive characterisation of cerebrovascular stiffness

Autori: B. Ghitti, S. Dempsey, A. Sharifzadeh-Kermani, F. Argus, and G. Maso Talou
Editore: CMBE 2026 Proceedings

Large deformation diffeomorphic cardiac strain mapping

Autori: Moscoloni B, Segers P, Peirlinck M
Editore: ArXiv
DOI: 10.48550/ARXIV.2504.03291

Network-level hemodynamic consequences of pericyte-induced capillary stalls in skeletal muscle microvasculature

Autori: S. Liu, G. Maso Talou, B. Ghitti, H. Davis, and F. Argus
Editore: CMBE2026 Proceedings

A Computational Model of the Sympathetic Neuron for Drug Treatment Investigation in Sympathetic Hyperactivity

Autori: Finbar John Argus
Pubblicato in: Computing in Cardiology Conference (CinC), 2024 Computing in Cardiology Conference (CinC), Numero 51, 2024
Editore: Computing in Cardiology
DOI: 10.22489/CINC.2024.142

Speeding up the computational time of biological models via automatic mathematical conversion

Autori: R. Lee, A. Garny, and F. Argus
Editore: CMBE 2026 Proceedings

GROWTH AND REMODELLING OF THE FEMORAL ARTERY IN RESPONSE TO SIMULATED MICROGRAVITY: IN VIVO ANALYSIS

Autori: Alessandro Giudici1, Shaiv Parikh2, Karen Barchetti3, Umit Gencer3,4, Hakim Khettab3,4, Elie Mousseaux3,4, Carole Leguy5, Tammo Delhaas1, Rosa Maria Bruno3, Pierre Boutouyrie3,4, and Bart Spronck
Editore: CMBE2026
DOI: 10.5281/ZENODO.21775715

Peer reviewed articles (22)

Unveiling sex dimorphism in the healthy cardiac anatomy: Fundamental differences between male and female heart shapes

Autori: Beatrice Moscoloni, Cameron Beeche, Julio A. Chirinos, Patrick Segers, Mathias Peirlinck
Pubblicato in: The Journal of Physiology, Numero 604, 2026, ISSN 0022-3751
Editore: Wiley
DOI: 10.1113/JP288667

Energy-based bond graph models of glucose transport with SLC transporters

Autori: Peter J. Hunter, Weiwei Ai, David P. Nickerson
Pubblicato in: Biophysical Journal, Numero 124, 2025, ISSN 0006-3495
Editore: Elsevier BV
DOI: 10.5281/zenodo.15100941

Impact of Dynamic Axial Stretching on the Arterial Pulse Wave Velocity: Physical Foundation and Clinical Implications

Autori: Shaiv Parikh, Koen D. Reesink, Bart Spronck, Tammo Delhaas, Alessandro Giudici
Pubblicato in: Annals of Biomedical Engineering, Numero 54, 2026, ISSN 0090-6964
Editore: Springer Science and Business Media LLC
DOI: 10.1007/S10439-025-03940-7

Instability in Computational Models of Vascular Smooth Muscle Cell Contraction

Autori: Alessandro Giudici, Jason M. Szafron, Abhay B. Ramachandra, Bart Spronck
Pubblicato in: Annals of Biomedical Engineering, Numero 52, 2024, ISSN 0090-6964
Editore: Springer Science and Business Media LLC
DOI: 10.1007/s10439-024-03532-x

Non-invasive evaluation of the hemodynamic significance of renal artery stenosis in fibromuscular dysplasia through quantitative image analysis

Autori: Alessandro Giudici, Tom Robberechts, Jacek Kądziela, Maria S Stoenoiu, Philippe Delmotte, Kim M Donkers, Jojanne E Van Leeuwen, Laurent Toubiana, Andrzej Januszewicz, Magda Januszewicz, Alexandre Persu, Bart Spronck
Pubblicato in: Polish Heart Journal, Numero 84, 2026, ISSN 1897-4279
Editore: Polskie Towarzystwo Kardiologiczne
DOI: 10.33963/V.PHJ.108870

Assessing vascular health by measuring arterial stiffness in response to hemodynamic load

Autori: Sanam Khataei, Kaveh Jafari, Catherine Fortier, Emy Philibert, Elizabeth de Rico, Bart Spronck, Alessandro Guidici, Hasan Obeid, Saliha Addour, Emmanuel Bujold, Rémi Goupil, Mohsen Agharazii
Pubblicato in: Journal of Hypertension, Numero 44, 2026, ISSN 0263-6352
Editore: Ovid Technologies (Wolters Kluwer Health)
DOI: 10.1097/HJH.0000000000004230

A Constitutive Modelling Outlook on Arterial (dys)function: Bridging the Gap with the Clinic

Autori: A. Giudici
Pubblicato in: Artery Research, Numero 32, 2026, ISSN 1876-4401
Editore: Springer Science and Business Media LLC
DOI: 10.1007/S44200-026-00116-Z

The role of vascular smooth muscle cell plasticity in arterial remodelling and biomechanical failure: a numerical approach

Autori: Yousof M. A. Abdel-Raouf, Lauranne Maes, Ludovica Maga, Julie De Backer, Patrick Sips, Mathias Peirlinck, Nele Famaey, Jay D. Humphrey, Patrick Segers
Pubblicato in: Proceedings of the Royal Society A Mathematical Physical and Engineering Science, Numero 482, 2026, ISSN 1364-5021
Editore: The Royal Society
DOI: 10.1098/RSPA.2025.0787

Human Aortic Vasoreactivity in Response to Various Stimuli: A Review

Autori: Cindy van Loo, Stan M.R.L. Toonen, Leon J. Schurgers, Tammo Delhaas, Bart Spronck
Pubblicato in: Pulse, Numero 13, 2025, ISSN 2235-8676
Editore: S. Karger AG
DOI: 10.1159/000547617

A constitutive modelling framework for applications to <i>in vivo</i> longitudinal data: Evaluation in a 60‐day head‐down bed rest study on arterial function

Autori: Alessandro Giudici, Karen Barchetti, Umit Gencer, Hakim Khettab, Elie Mousseaux, Carole Leguy, Tammo Delhaas, Rosa Maria Bruno, Bart Spronck, Pierre Boutouyrie
Pubblicato in: The Journal of Physiology, 2026, ISSN 0022-3751
Editore: Wiley
DOI: 10.1113/JP289863

Vascular aging impairs active modulation of murine aortic stiffness by smooth muscle cells

Autori: Koen W. F. van der Laan, Cédric H. G. Neutel, Margarita G. Pencheva, Callan D. Wesley, Dustin N. Krüger, Casper G. Schalkwijk, Guido R. Y. De Meyer, Wim Martinet, Koen D. Reesink, Tammo Delhaas, Alessandro Giudici, Pieter-Jan Guns, Bart Spronck
Pubblicato in: American Journal of Physiology-Cell Physiology, Numero 329, 2025, ISSN 0363-6143
Editore: American Physiological Society
DOI: 10.1152/AJPCELL.00387.2025

Full-field surrogate modeling of cardiac electrophysiology encoding geometric variability

Autori: Elena Sabdy Martinez, Beatrice Moscoloni, Matteo Salvador, Fanwei Kong, Mathias Peirlinck, Alison Lesley Marsden
Pubblicato in: Computer Methods in Applied Mechanics and Engineering, Numero 448, 2026, ISSN 0045-7825
Editore: Elsevier BV
DOI: 10.1016/J.CMA.2025.118444

Biaxial biomechanics of aged human carotid arteries

Autori: Cindy van Loo, Kailey A. Stevens, Taisiya Sigaeva, Alessandro Giudici, Leon J. Schurgers, Tammo Delhaas, Jason S. Au, Bart Spronck
Pubblicato in: Journal of the Mechanical Behavior of Biomedical Materials, Numero 182, 2026, ISSN 1751-6161
Editore: Elsevier BV
DOI: 10.1016/J.JMBBM.2026.107529

Accounting for approximation errors using surrogate-based parameter estimation of cardiac mechanics digital twins

Autori: F. Argus, S.A. Creamer, R. Nicholson, O.J. Maclaren, G.D. Maso Talou, V.Y. Wang, D. Zhao, A.A. Young, M.P. Nash, T.P. Babarenda Gamage
Pubblicato in: Computer Methods and Programs in Biomedicine, Numero 285, 2026, ISSN 0169-2607
Editore: Elsevier BV
DOI: 10.1016/J.CMPB.2026.109528

Anxiety and depression in cardiac amyloidosis: a systematic review

Autori: Simon Ghinassi, Lucia Ponti, Martina Smorti, Francesco Cappelli
Pubblicato in: BMJ Open, Numero 15, 2025, ISSN 2044-6055
Editore: BMJ
DOI: 10.1136/BMJOPEN-2024-094614

The Physiome Project and Digital Twins

Autori: P. Hunter, B. de Bono, D. Brooks, R. Christie, J. Hussan, M. Lin, and D. Nickerso
Pubblicato in: IEEE Reviews in Biomedical Engineering, ISSN 3950-4298
Editore: IEEE
DOI: 10.5281/ZENODO.15100982

Phenomenological model of transthyretin stabilization

Autori: Bartek Lisowski, Seweryn Ulaszek, Barbara Wiśniowska, Veronika Bernhauerová, Sebastian Polak
Pubblicato in: Scientific Reports, Numero 16, 2026, ISSN 2045-2322
Editore: Springer Science and Business Media LLC
DOI: 10.1038/S41598-026-35000-Y

A software benchmark for cardiac elastodynamics

Autori: Reidmen Aróstica, David Nolte, Aaron Brown, Amadeus Gebauer, Elias Karabelas, Javiera Jilberto, Matteo Salvador, Michele Bucelli, Roberto Piersanti, Kasra Osouli, Christoph Augustin, Henrik Finsberg, Lei Shi, Marc Hirschvogel, Martin Pfaller, Pasquale Claudio Africa, Matthias Gsell, Alison Marsden, David Nordsletten, Francesco Regazzoni, Gernot Plank, Joakim Sundnes, Luca Dede’, Mathias Peirlinck, Vijay Vedula, Wolfgang Wall, Cristóbal Bertoglio
Pubblicato in: Computer Methods in Applied Mechanics and Engineering, Numero 435, 2025, ISSN 0045-7825
Editore: Elsevier BV
DOI: 10.5281/ZENODO.15100768

Machine learning-enabled estimation of cardiac output from peripheral waveforms is independent of blood pressure measurement location in an in silico population

Autori: Lydia Aslanidou, Georgios Rovas, Ramin Mohammadi, Sokratis Anagnostopoulos, Cemre Çelikbudak Orhon, Nikolaos Stergiopulos
Pubblicato in: Scientific Reports, Numero 15, 2025, ISSN 2045-2322
Editore: Springer Science and Business Media LLC
DOI: 10.1038/S41598-025-10492-2

Vasoactive Response of the Thoracic Aorta to Phenylephrine Infusion During Cardiac Surgery

Autori: Stan M.R.L. Toonen, Frederique M. de Raat, Cindy van Loo, Luuk van Knippenberg, Joris van Houte, Tammo Delhaas, Leon J. Schurgers, Ana Jerončić, Massimo Mischi, R. Arthur Bouwman, Leon J. Montenij, Bart Spronck
Pubblicato in: Journal of Applied Physiology, 2026, ISSN 8750-7587
Editore: American Physiological Society
DOI: 10.1152/JAPPLPHYSIOL.00996.2025

Exploring Tafamidis Effects Through PBPK–QSP Modelling

Autori: Seweryn Ulaszek, Bartek Lisowski, Barbara Wiśniowska, Sebastian Polak
Pubblicato in: Pharmaceutics, Numero 18, 2026, ISSN 1999-4923
Editore: MDPI AG
DOI: 10.3390/PHARMACEUTICS18030367

Significance of Dynamic Axial Stretching on Estimating Biomechanical Behavior and Properties of the Human Ascending Aorta

Autori: Shaiv Parikh, Alessandro Giudici, Wouter Huberts, Tammo Delhaas, Elham Bidar, Bart Spronck, Koen Reesink
Pubblicato in: Annals of Biomedical Engineering, Numero 52, 2024, ISSN 0090-6964
Editore: Springer Science and Business Media LLC
DOI: 10.5281/zenodo.15100877

Other (3)

Understanding the interplay of collagen and myocyte adaptation in cardiac volume overload: a multi-constituent growth and remodeling framework.

Autori: Maga L, Peirlinck M, Noel L
Editore: arXiv
DOI: 10.48550/ARXIV.2510.11670

Fast and Accurate Inverse Blood Flow Modeling from Minimal Cuff-Pressure Data via PINNs

Autori: Aslanidou L, Rovas G, Mohammadi R, Anagnostopoulos S, Celikbudak Orhon C., Stergiopulos N.
Editore: ArXiv

Flow-based conditional cardiac anatomy generation for virtual cohorts

Autori: Konstantinos Kevopoulos, Beatrice Moscoloni, Benjamin Alheit, Cameron Beeche, Julio A. Chirinos, Alexander Heinlein, Mathias Peirlinck
Editore: ArXiv
DOI: 10.48550/ARXIV.2608.09460