VIrtual Twins as tools for personalised clinicAL care

Informacje na temat projektu

VITAL

Identyfikator umowy o grant: 101136728

DOI

10.3030/101136728

Data podpisania przez KE 10 Listopada 2023

Data rozpoczęcia 1 Stycznia 2024

Data zakończenia 31 Grudnia 2028

Finansowanie w ramach

• Health

Koszt całkowity

€ 8 743 516,25

Wkład UE

€ 8 743 516,25

Koordynowany przez

UNIVERSITEIT GENT
Belgium

CORDIS oferuje możliwość skorzystania z odnośników do publicznie dostępnych publikacji i rezultatów projektów realizowanych w ramach programów ramowych HORYZONT.

Odnośniki do rezultatów i publikacji związanych z poszczególnymi projektami 7PR, a także odnośniki do niektórych konkretnych kategorii wyników, takich jak zbiory danych i oprogramowanie, są dynamicznie pobierane z systemu OpenAIRE .

Rezultaty

Websites, patent fillings, videos etc. (3)

Dissemination and communication plan

Dissemination and communication plan (T8.1).

Launch of project web-site

Launch of project web-site and setting up media channels (T8.2).

Dedicated templates, posters, brochures with the project logo and infographics

Dedicated templates, posters, brochures with the project logo and infographics (T8.4).

Documents, reports (2)

Project Management Handbook

Project Management Handbook describing the project management, risk management and quality assurance procedures and including templates for progress and financial reporting (T1.1).

Initial Sustainability and Exploitation plan

First version of an exploitation plan for the VITAL project (T7.6).

Other (1)

First Technical hands-on modelling training school

First Technical hands-on modelling training school (T8.3).

Data Management Plan (1)

Data Management Plan

First version of the Data Management Plan: Data Management Plan outlines how data will be collected/handled/stored according to the FAIR principles (T1.3).

Publikacje

Conference proceedings (7)

Action potential encoding for efficient axon propogation computation

Autorzy: James Zeng, Gonzalo Maso Talou, Finbar Argus
Wydawca: CMBE 2026 Proceedings

MRI-informed haemodynamic modelling for noninvasive characterisation of cerebrovascular stiffness

Autorzy: B. Ghitti, S. Dempsey, A. Sharifzadeh-Kermani, F. Argus, and G. Maso Talou
Wydawca: CMBE 2026 Proceedings

Large deformation diffeomorphic cardiac strain mapping

Autorzy: Moscoloni B, Segers P, Peirlinck M
Wydawca: ArXiv
DOI: 10.48550/ARXIV.2504.03291

Network-level hemodynamic consequences of pericyte-induced capillary stalls in skeletal muscle microvasculature

Autorzy: S. Liu, G. Maso Talou, B. Ghitti, H. Davis, and F. Argus
Wydawca: CMBE2026 Proceedings

A Computational Model of the Sympathetic Neuron for Drug Treatment Investigation in Sympathetic Hyperactivity

Autorzy: Finbar John Argus
Opublikowane w: Computing in Cardiology Conference (CinC), 2024 Computing in Cardiology Conference (CinC), Numer 51, 2024
Wydawca: Computing in Cardiology
DOI: 10.22489/CINC.2024.142

Speeding up the computational time of biological models via automatic mathematical conversion

Autorzy: R. Lee, A. Garny, and F. Argus
Wydawca: CMBE 2026 Proceedings

GROWTH AND REMODELLING OF THE FEMORAL ARTERY IN RESPONSE TO SIMULATED MICROGRAVITY: IN VIVO ANALYSIS

Autorzy: Alessandro Giudici1, Shaiv Parikh2, Karen Barchetti3, Umit Gencer3,4, Hakim Khettab3,4, Elie Mousseaux3,4, Carole Leguy5, Tammo Delhaas1, Rosa Maria Bruno3, Pierre Boutouyrie3,4, and Bart Spronck
Wydawca: CMBE2026
DOI: 10.5281/ZENODO.21775715

Peer reviewed articles (22)

Unveiling sex dimorphism in the healthy cardiac anatomy: Fundamental differences between male and female heart shapes

Autorzy: Beatrice Moscoloni, Cameron Beeche, Julio A. Chirinos, Patrick Segers, Mathias Peirlinck
Opublikowane w: The Journal of Physiology, Numer 604, 2026, ISSN 0022-3751
Wydawca: Wiley
DOI: 10.1113/JP288667

Energy-based bond graph models of glucose transport with SLC transporters

Autorzy: Peter J. Hunter, Weiwei Ai, David P. Nickerson
Opublikowane w: Biophysical Journal, Numer 124, 2025, ISSN 0006-3495
Wydawca: Elsevier BV
DOI: 10.5281/zenodo.15100941

Impact of Dynamic Axial Stretching on the Arterial Pulse Wave Velocity: Physical Foundation and Clinical Implications

Autorzy: Shaiv Parikh, Koen D. Reesink, Bart Spronck, Tammo Delhaas, Alessandro Giudici
Opublikowane w: Annals of Biomedical Engineering, Numer 54, 2026, ISSN 0090-6964
Wydawca: Springer Science and Business Media LLC
DOI: 10.1007/S10439-025-03940-7

Instability in Computational Models of Vascular Smooth Muscle Cell Contraction

Autorzy: Alessandro Giudici, Jason M. Szafron, Abhay B. Ramachandra, Bart Spronck
Opublikowane w: Annals of Biomedical Engineering, Numer 52, 2024, ISSN 0090-6964
Wydawca: Springer Science and Business Media LLC
DOI: 10.1007/s10439-024-03532-x

Non-invasive evaluation of the hemodynamic significance of renal artery stenosis in fibromuscular dysplasia through quantitative image analysis

Autorzy: Alessandro Giudici, Tom Robberechts, Jacek Kądziela, Maria S Stoenoiu, Philippe Delmotte, Kim M Donkers, Jojanne E Van Leeuwen, Laurent Toubiana, Andrzej Januszewicz, Magda Januszewicz, Alexandre Persu, Bart Spronck
Opublikowane w: Polish Heart Journal, Numer 84, 2026, ISSN 1897-4279
Wydawca: Polskie Towarzystwo Kardiologiczne
DOI: 10.33963/V.PHJ.108870

Assessing vascular health by measuring arterial stiffness in response to hemodynamic load

Autorzy: Sanam Khataei, Kaveh Jafari, Catherine Fortier, Emy Philibert, Elizabeth de Rico, Bart Spronck, Alessandro Guidici, Hasan Obeid, Saliha Addour, Emmanuel Bujold, Rémi Goupil, Mohsen Agharazii
Opublikowane w: Journal of Hypertension, Numer 44, 2026, ISSN 0263-6352
Wydawca: Ovid Technologies (Wolters Kluwer Health)
DOI: 10.1097/HJH.0000000000004230

A Constitutive Modelling Outlook on Arterial (dys)function: Bridging the Gap with the Clinic

Autorzy: A. Giudici
Opublikowane w: Artery Research, Numer 32, 2026, ISSN 1876-4401
Wydawca: Springer Science and Business Media LLC
DOI: 10.1007/S44200-026-00116-Z

The role of vascular smooth muscle cell plasticity in arterial remodelling and biomechanical failure: a numerical approach

Autorzy: Yousof M. A. Abdel-Raouf, Lauranne Maes, Ludovica Maga, Julie De Backer, Patrick Sips, Mathias Peirlinck, Nele Famaey, Jay D. Humphrey, Patrick Segers
Opublikowane w: Proceedings of the Royal Society A Mathematical Physical and Engineering Science, Numer 482, 2026, ISSN 1364-5021
Wydawca: The Royal Society
DOI: 10.1098/RSPA.2025.0787

Human Aortic Vasoreactivity in Response to Various Stimuli: A Review

Autorzy: Cindy van Loo, Stan M.R.L. Toonen, Leon J. Schurgers, Tammo Delhaas, Bart Spronck
Opublikowane w: Pulse, Numer 13, 2025, ISSN 2235-8676
Wydawca: S. Karger AG
DOI: 10.1159/000547617

A constitutive modelling framework for applications to <i>in vivo</i> longitudinal data: Evaluation in a 60‐day head‐down bed rest study on arterial function

Autorzy: Alessandro Giudici, Karen Barchetti, Umit Gencer, Hakim Khettab, Elie Mousseaux, Carole Leguy, Tammo Delhaas, Rosa Maria Bruno, Bart Spronck, Pierre Boutouyrie
Opublikowane w: The Journal of Physiology, 2026, ISSN 0022-3751
Wydawca: Wiley
DOI: 10.1113/JP289863

Vascular aging impairs active modulation of murine aortic stiffness by smooth muscle cells

Autorzy: Koen W. F. van der Laan, Cédric H. G. Neutel, Margarita G. Pencheva, Callan D. Wesley, Dustin N. Krüger, Casper G. Schalkwijk, Guido R. Y. De Meyer, Wim Martinet, Koen D. Reesink, Tammo Delhaas, Alessandro Giudici, Pieter-Jan Guns, Bart Spronck
Opublikowane w: American Journal of Physiology-Cell Physiology, Numer 329, 2025, ISSN 0363-6143
Wydawca: American Physiological Society
DOI: 10.1152/AJPCELL.00387.2025

Full-field surrogate modeling of cardiac electrophysiology encoding geometric variability

Autorzy: Elena Sabdy Martinez, Beatrice Moscoloni, Matteo Salvador, Fanwei Kong, Mathias Peirlinck, Alison Lesley Marsden
Opublikowane w: Computer Methods in Applied Mechanics and Engineering, Numer 448, 2026, ISSN 0045-7825
Wydawca: Elsevier BV
DOI: 10.1016/J.CMA.2025.118444

Biaxial biomechanics of aged human carotid arteries

Autorzy: Cindy van Loo, Kailey A. Stevens, Taisiya Sigaeva, Alessandro Giudici, Leon J. Schurgers, Tammo Delhaas, Jason S. Au, Bart Spronck
Opublikowane w: Journal of the Mechanical Behavior of Biomedical Materials, Numer 182, 2026, ISSN 1751-6161
Wydawca: Elsevier BV
DOI: 10.1016/J.JMBBM.2026.107529

Accounting for approximation errors using surrogate-based parameter estimation of cardiac mechanics digital twins

Autorzy: F. Argus, S.A. Creamer, R. Nicholson, O.J. Maclaren, G.D. Maso Talou, V.Y. Wang, D. Zhao, A.A. Young, M.P. Nash, T.P. Babarenda Gamage
Opublikowane w: Computer Methods and Programs in Biomedicine, Numer 285, 2026, ISSN 0169-2607
Wydawca: Elsevier BV
DOI: 10.1016/J.CMPB.2026.109528

Anxiety and depression in cardiac amyloidosis: a systematic review

Autorzy: Simon Ghinassi, Lucia Ponti, Martina Smorti, Francesco Cappelli
Opublikowane w: BMJ Open, Numer 15, 2025, ISSN 2044-6055
Wydawca: BMJ
DOI: 10.1136/BMJOPEN-2024-094614

The Physiome Project and Digital Twins

Autorzy: P. Hunter, B. de Bono, D. Brooks, R. Christie, J. Hussan, M. Lin, and D. Nickerso
Opublikowane w: IEEE Reviews in Biomedical Engineering, ISSN 3950-4298
Wydawca: IEEE
DOI: 10.5281/ZENODO.15100982

Phenomenological model of transthyretin stabilization

Autorzy: Bartek Lisowski, Seweryn Ulaszek, Barbara Wiśniowska, Veronika Bernhauerová, Sebastian Polak
Opublikowane w: Scientific Reports, Numer 16, 2026, ISSN 2045-2322
Wydawca: Springer Science and Business Media LLC
DOI: 10.1038/S41598-026-35000-Y

A software benchmark for cardiac elastodynamics

Autorzy: Reidmen Aróstica, David Nolte, Aaron Brown, Amadeus Gebauer, Elias Karabelas, Javiera Jilberto, Matteo Salvador, Michele Bucelli, Roberto Piersanti, Kasra Osouli, Christoph Augustin, Henrik Finsberg, Lei Shi, Marc Hirschvogel, Martin Pfaller, Pasquale Claudio Africa, Matthias Gsell, Alison Marsden, David Nordsletten, Francesco Regazzoni, Gernot Plank, Joakim Sundnes, Luca Dede’, Mathias Peirlinck, Vijay Vedula, Wolfgang Wall, Cristóbal Bertoglio
Opublikowane w: Computer Methods in Applied Mechanics and Engineering, Numer 435, 2025, ISSN 0045-7825
Wydawca: Elsevier BV
DOI: 10.5281/ZENODO.15100768

Machine learning-enabled estimation of cardiac output from peripheral waveforms is independent of blood pressure measurement location in an in silico population

Autorzy: Lydia Aslanidou, Georgios Rovas, Ramin Mohammadi, Sokratis Anagnostopoulos, Cemre Çelikbudak Orhon, Nikolaos Stergiopulos
Opublikowane w: Scientific Reports, Numer 15, 2025, ISSN 2045-2322
Wydawca: Springer Science and Business Media LLC
DOI: 10.1038/S41598-025-10492-2

Vasoactive Response of the Thoracic Aorta to Phenylephrine Infusion During Cardiac Surgery

Autorzy: Stan M.R.L. Toonen, Frederique M. de Raat, Cindy van Loo, Luuk van Knippenberg, Joris van Houte, Tammo Delhaas, Leon J. Schurgers, Ana Jerončić, Massimo Mischi, R. Arthur Bouwman, Leon J. Montenij, Bart Spronck
Opublikowane w: Journal of Applied Physiology, 2026, ISSN 8750-7587
Wydawca: American Physiological Society
DOI: 10.1152/JAPPLPHYSIOL.00996.2025

Exploring Tafamidis Effects Through PBPK–QSP Modelling

Autorzy: Seweryn Ulaszek, Bartek Lisowski, Barbara Wiśniowska, Sebastian Polak
Opublikowane w: Pharmaceutics, Numer 18, 2026, ISSN 1999-4923
Wydawca: MDPI AG
DOI: 10.3390/PHARMACEUTICS18030367

Significance of Dynamic Axial Stretching on Estimating Biomechanical Behavior and Properties of the Human Ascending Aorta

Autorzy: Shaiv Parikh, Alessandro Giudici, Wouter Huberts, Tammo Delhaas, Elham Bidar, Bart Spronck, Koen Reesink
Opublikowane w: Annals of Biomedical Engineering, Numer 52, 2024, ISSN 0090-6964
Wydawca: Springer Science and Business Media LLC
DOI: 10.5281/zenodo.15100877

Other (3)

Understanding the interplay of collagen and myocyte adaptation in cardiac volume overload: a multi-constituent growth and remodeling framework.

Autorzy: Maga L, Peirlinck M, Noel L
Wydawca: arXiv
DOI: 10.48550/ARXIV.2510.11670

Fast and Accurate Inverse Blood Flow Modeling from Minimal Cuff-Pressure Data via PINNs

Autorzy: Aslanidou L, Rovas G, Mohammadi R, Anagnostopoulos S, Celikbudak Orhon C., Stergiopulos N.
Wydawca: ArXiv

Flow-based conditional cardiac anatomy generation for virtual cohorts

Autorzy: Konstantinos Kevopoulos, Beatrice Moscoloni, Benjamin Alheit, Cameron Beeche, Julio A. Chirinos, Alexander Heinlein, Mathias Peirlinck
Wydawca: ArXiv
DOI: 10.48550/ARXIV.2608.09460