Targeting tumour-host interactions in paediatric malignant gliomas to reinvigorate immunity and improve radio- and immunotherapy efficacy

Project Information

HIT-GLIO

Grant agreement ID: 101136835

DOI

10.3030/101136835

EC signature date 7 December 2023

Start date 1 December 2023

End date 30 November 2027

Funded under

• Health

Total cost

€ 9 650 975,00

EU contribution

€ 9 650 975,00

Coordinated by

INSTYTUT BIOLOGII DOSWIADCZALNEJ IM. M. NENCKIEGO POLSKIEJ AKADEMII NAUK
Poland

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (7)

UPR-induced intracellular C5aR1 promotes adaptation to the hypoxic tumour microenvironment

Author(s): Tatsuya Suwa, Kelly SW. Lee, Ian J. Chai, Heather O. L. Clark, David J. MacLean, Nicole Machado, Gonzalo Rodriguez-Berriguete, Lolita Singh, Geoff S. Higgins, Ester M. Hammond, Monica M. Olcina
Published in: Cell Death & Disease, Issue 16, 2025, ISSN 2041-4889
Publisher: Springer Science and Business Media LLC
DOI: 10.1101/2024.09.27.615431V1

Self-assembling dendrimer nanosystems for specific fluorine magnetic resonance imaging and effective theranostic treatment of tumors

Author(s): Zhenbin Lyu, Brigino Ralahy, Teodora-Adriana Perles-Barbacaru, Ling Ding, Yifan Jiang, Baoping Lian, Tom Roussel, Xi Liu, Christina Galanakou, Erik Laurini, Aura Tintaru, Suzanne Giorgio, Sabrina Pricl, Xiaoxuan Liu, Monique Bernard, Juan Iovanna, Angèle Viola, Ling Peng
Published in: Proceedings of the National Academy of Sciences, Issue 121, 2024, ISSN 0027-8424
Publisher: Proceedings of the National Academy of Sciences
DOI: 10.1073/PNAS.2322403121

Dendrimer engineering to overcome delivery challenges of nucleic acids

Author(s): Qianqian Ni, Jing Wu, Christina Galanakou, Cheng-Cai Zhang, Donald A. Tomalia, Ling Peng
Published in: Nat. Rev. Bioeng, 2025, ISSN 2731-6092
Publisher: Springer Nature
DOI: 10.1038/S44222-025-00347-W

Self-assembling dendrimer nanodrug formulations for decreased hERG-related toxicity and enhanced therapeutic efficacy

Author(s): Xi Liu, Dinesh Dhumal, Patricia Santofimia-Castaño, Juan Liu, Marion Casanova, Alicia Comino Garcia-Muñoz, Teodora-Adriana Perles-Barbacaru, Abdechakour Elkihel, Wenzheng Zhang, Tom Roussel, Christina Galanakou, Jing Wu, Eleni Zerva, Nelson Dusetti, Yi Xia, Xing-Jie Liang, Angèle Viola, Juan L. Iovanna, Ling Peng
Published in: Science Advances, Issue 11, 2025, ISSN 2375-2548
Publisher: American Association for the Advancement of Science (AAAS)
DOI: 10.1126/SCIADV.ADU9948

Hypoxic stress dysregulates functions of glioma-associated myeloid cells through epigenomic and transcriptional programs

Author(s): Monika Dzwigonska, Patrycja Rosa, Szymon Lipiec, Tomasz Obrebski, Gabriela Smyk, Beata Kaza, Salwador Cyranowski, Aleksandra Ellert-Miklaszewska, Agata Kominek, Anna R. Malik, Katarzyna Piwocka, Jakub Mieczkowski, Bozena Kaminska, Katarzyna B. Leszczynska
Published in: Cell Reports, Issue 44, 2025, ISSN 2211-1247
Publisher: Elsevier BV
DOI: 10.1101/2024.09.12.612769V2

Elevated reactive oxygen species can drive the alternative lengthening of telomeres pathway in ATRX-null cancers

Author(s): Tomas Goncalves, Siobhan Cunniffe, Tiffany S Ma, Natalie Mattis, Andrew W Rose, Thomas Kent, David R Mole, Helene E B Geiller, Linda van Bijsterveldt, Timothy C Humphrey, Ester M Hammond, Richard J Gibbons, David Clynes, Anna M Rose
Published in: Nucleic Acids Research, Issue 53, 2025, ISSN 0305-1048
Publisher: Oxford University Press (OUP)
DOI: 10.1093/NAR/GKAF061

Indolequinone-Based Hypoxia-Activated Proteolysis Targeting Chimeras Selectively Degrade BRD4 in Hypoxic Cancer Cells

Author(s): Marta Serafini, Sophie A. Twigger, George Delfas, Maxim Mallerman, Elliot P. Bailey, Ewen D. D. Calder, Ester M. Hammond, Stuart J. Conway
Published in: Journal of the American Chemical Society, 2025, ISSN 0002-7863
Publisher: American Chemical Society (ACS)
DOI: 10.1021/JACS.5C10240