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CORDIS - Risultati della ricerca dell’UE
CORDIS

Targeting tumour-host interactions in paediatric malignant gliomas to reinvigorate immunity and improve radio- and immunotherapy efficacy

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

HIT-GLIO 10K run event (si apre in una nuova finestra)

Public outreach with the HIT-GLIO project via charity run synchronised in all the countries of the consortium by participants to increase awareness and raise funding for the children with pHGG and their families.

Common work plan for scientific collaboration under the “Understanding (tumour-host interactions)”cluster (si apre in una nuova finestra)
1st Policy brief formulating recommendations based on the research and innovation strand of the “Understanding (tumour-host interactions)”annual cluster meeting (si apre in una nuova finestra)

1st Policy brief formulating recommendations based on the research and innovation strand of the “Understanding (tumour-host interactions)” annual cluster meeting

CLEPIC 2024 (si apre in una nuova finestra)

Organisation of a session on epigenetically-driven tumours at International Clinical Epigenetics Conference (CLEPIC) in Warsaw and exposing HIT-GLIO results to the world experts in the field.

Brain Tumors meeting 2025 in Warsaw (si apre in una nuova finestra)

Organisation of a session on pHGG therapy during Brain Tumors meeting and exposing HIT-GLIO results to the world experts in the field.

Plan for Dissemination, Exploitation and Communication (si apre in una nuova finestra)

Plan for Dissemination, Exploitation and Communication including communication activities will be developed and submitted in Month 3, and updated regularly.

1st Conclusions of common annual meeting of the “Understanding (tumour-host interactions)” cluster (si apre in una nuova finestra)

Conclusions of common annual meeting of the “Understanding (tumour-host interactions)” cluster

Common video and/or a common cluster brochure (si apre in una nuova finestra)

A common video and/or a common cluster brochure will be produced as a result of the project contribution to the Cancer Mission cluster of projects on “Understanding (tumour-host interactions)”.

HIT-GLIO website (si apre in una nuova finestra)

A public website-based platform dedicated to HIT-GLIO project. Sensitive unpublished data will be safelocked with a password for communication and data exchange between partners and in the future with interested initiatives and stakeholders

Data management plan (si apre in una nuova finestra)

A detailed data management plan provided by each participant and updated when necessary

Pubblicazioni

UPR-induced intracellular C5aR1 promotes adaptation to the hypoxic tumour microenvironment (si apre in una nuova finestra)

Autori: Tatsuya Suwa, Kelly SW. Lee, Ian J. Chai, Heather O. L. Clark, David J. MacLean, Nicole Machado, Gonzalo Rodriguez-Berriguete, Lolita Singh, Geoff S. Higgins, Ester M. Hammond, Monica M. Olcina
Pubblicato in: Cell Death & Disease, Numero 16, 2025, ISSN 2041-4889
Editore: Springer Science and Business Media LLC
DOI: 10.1101/2024.09.27.615431V1

Self-assembling dendrimer nanosystems for specific fluorine magnetic resonance imaging and effective theranostic treatment of tumors (si apre in una nuova finestra)

Autori: Zhenbin Lyu, Brigino Ralahy, Teodora-Adriana Perles-Barbacaru, Ling Ding, Yifan Jiang, Baoping Lian, Tom Roussel, Xi Liu, Christina Galanakou, Erik Laurini, Aura Tintaru, Suzanne Giorgio, Sabrina Pricl, Xiaoxuan Liu, Monique Bernard, Juan Iovanna, Angèle Viola, Ling Peng
Pubblicato in: Proceedings of the National Academy of Sciences, Numero 121, 2024, ISSN 0027-8424
Editore: Proceedings of the National Academy of Sciences
DOI: 10.1073/PNAS.2322403121

Dendrimer engineering to overcome delivery challenges of nucleic acids (si apre in una nuova finestra)

Autori: Qianqian Ni, Jing Wu, Christina Galanakou, Cheng-Cai Zhang, Donald A. Tomalia, Ling Peng
Pubblicato in: Nat. Rev. Bioeng, 2025, ISSN 2731-6092
Editore: Springer Nature
DOI: 10.1038/S44222-025-00347-W

Self-assembling dendrimer nanodrug formulations for decreased hERG-related toxicity and enhanced therapeutic efficacy (si apre in una nuova finestra)

Autori: Xi Liu, Dinesh Dhumal, Patricia Santofimia-Castaño, Juan Liu, Marion Casanova, Alicia Comino Garcia-Muñoz, Teodora-Adriana Perles-Barbacaru, Abdechakour Elkihel, Wenzheng Zhang, Tom Roussel, Christina Galanakou, Jing Wu, Eleni Zerva, Nelson Dusetti, Yi Xia, Xing-Jie Liang, Angèle Viola, Juan L. Iovanna, Ling Peng
Pubblicato in: Science Advances, Numero 11, 2025, ISSN 2375-2548
Editore: American Association for the Advancement of Science (AAAS)
DOI: 10.1126/SCIADV.ADU9948

Hypoxic stress dysregulates functions of glioma-associated myeloid cells through epigenomic and transcriptional programs (si apre in una nuova finestra)

Autori: Monika Dzwigonska, Patrycja Rosa, Szymon Lipiec, Tomasz Obrebski, Gabriela Smyk, Beata Kaza, Salwador Cyranowski, Aleksandra Ellert-Miklaszewska, Agata Kominek, Anna R. Malik, Katarzyna Piwocka, Jakub Mieczkowski, Bozena Kaminska, Katarzyna B. Leszczynska
Pubblicato in: Cell Reports, Numero 44, 2025, ISSN 2211-1247
Editore: Elsevier BV
DOI: 10.1101/2024.09.12.612769V2

Elevated reactive oxygen species can drive the alternative lengthening of telomeres pathway in ATRX-null cancers (si apre in una nuova finestra)

Autori: Tomas Goncalves, Siobhan Cunniffe, Tiffany S Ma, Natalie Mattis, Andrew W Rose, Thomas Kent, David R Mole, Helene E B Geiller, Linda van Bijsterveldt, Timothy C Humphrey, Ester M Hammond, Richard J Gibbons, David Clynes, Anna M Rose
Pubblicato in: Nucleic Acids Research, Numero 53, 2025, ISSN 0305-1048
Editore: Oxford University Press (OUP)
DOI: 10.1093/NAR/GKAF061

Indolequinone-Based Hypoxia-Activated Proteolysis Targeting Chimeras Selectively Degrade BRD4 in Hypoxic Cancer Cells (si apre in una nuova finestra)

Autori: Marta Serafini, Sophie A. Twigger, George Delfas, Maxim Mallerman, Elliot P. Bailey, Ewen D. D. Calder, Ester M. Hammond, Stuart J. Conway
Pubblicato in: Journal of the American Chemical Society, 2025, ISSN 0002-7863
Editore: American Chemical Society (ACS)
DOI: 10.1021/JACS.5C10240

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