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CORDIS - Resultados de investigaciones de la UE
CORDIS

Targeting tumour-host interactions in paediatric malignant gliomas to reinvigorate immunity and improve radio- and immunotherapy efficacy

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

HIT-GLIO 10K run event (se abrirá en una nueva ventana)

Public outreach with the HIT-GLIO project via charity run synchronised in all the countries of the consortium by participants to increase awareness and raise funding for the children with pHGG and their families.

Common work plan for scientific collaboration under the “Understanding (tumour-host interactions)”cluster (se abrirá en una nueva ventana)
1st Policy brief formulating recommendations based on the research and innovation strand of the “Understanding (tumour-host interactions)”annual cluster meeting (se abrirá en una nueva ventana)

1st Policy brief formulating recommendations based on the research and innovation strand of the “Understanding (tumour-host interactions)” annual cluster meeting

CLEPIC 2024 (se abrirá en una nueva ventana)

Organisation of a session on epigenetically-driven tumours at International Clinical Epigenetics Conference (CLEPIC) in Warsaw and exposing HIT-GLIO results to the world experts in the field.

Brain Tumors meeting 2025 in Warsaw (se abrirá en una nueva ventana)

Organisation of a session on pHGG therapy during Brain Tumors meeting and exposing HIT-GLIO results to the world experts in the field.

Plan for Dissemination, Exploitation and Communication (se abrirá en una nueva ventana)

Plan for Dissemination, Exploitation and Communication including communication activities will be developed and submitted in Month 3, and updated regularly.

1st Conclusions of common annual meeting of the “Understanding (tumour-host interactions)” cluster (se abrirá en una nueva ventana)

Conclusions of common annual meeting of the “Understanding (tumour-host interactions)” cluster

Common video and/or a common cluster brochure (se abrirá en una nueva ventana)

A common video and/or a common cluster brochure will be produced as a result of the project contribution to the Cancer Mission cluster of projects on “Understanding (tumour-host interactions)”.

HIT-GLIO website (se abrirá en una nueva ventana)

A public website-based platform dedicated to HIT-GLIO project. Sensitive unpublished data will be safelocked with a password for communication and data exchange between partners and in the future with interested initiatives and stakeholders

Data management plan (se abrirá en una nueva ventana)

A detailed data management plan provided by each participant and updated when necessary

Publicaciones

UPR-induced intracellular C5aR1 promotes adaptation to the hypoxic tumour microenvironment (se abrirá en una nueva ventana)

Autores: Tatsuya Suwa, Kelly SW. Lee, Ian J. Chai, Heather O. L. Clark, David J. MacLean, Nicole Machado, Gonzalo Rodriguez-Berriguete, Lolita Singh, Geoff S. Higgins, Ester M. Hammond, Monica M. Olcina
Publicado en: Cell Death & Disease, Edición 16, 2025, ISSN 2041-4889
Editor: Springer Science and Business Media LLC
DOI: 10.1101/2024.09.27.615431V1

Self-assembling dendrimer nanosystems for specific fluorine magnetic resonance imaging and effective theranostic treatment of tumors (se abrirá en una nueva ventana)

Autores: Zhenbin Lyu, Brigino Ralahy, Teodora-Adriana Perles-Barbacaru, Ling Ding, Yifan Jiang, Baoping Lian, Tom Roussel, Xi Liu, Christina Galanakou, Erik Laurini, Aura Tintaru, Suzanne Giorgio, Sabrina Pricl, Xiaoxuan Liu, Monique Bernard, Juan Iovanna, Angèle Viola, Ling Peng
Publicado en: Proceedings of the National Academy of Sciences, Edición 121, 2024, ISSN 0027-8424
Editor: Proceedings of the National Academy of Sciences
DOI: 10.1073/PNAS.2322403121

Dendrimer engineering to overcome delivery challenges of nucleic acids (se abrirá en una nueva ventana)

Autores: Qianqian Ni, Jing Wu, Christina Galanakou, Cheng-Cai Zhang, Donald A. Tomalia, Ling Peng
Publicado en: Nat. Rev. Bioeng, 2025, ISSN 2731-6092
Editor: Springer Nature
DOI: 10.1038/S44222-025-00347-W

Self-assembling dendrimer nanodrug formulations for decreased hERG-related toxicity and enhanced therapeutic efficacy (se abrirá en una nueva ventana)

Autores: Xi Liu, Dinesh Dhumal, Patricia Santofimia-Castaño, Juan Liu, Marion Casanova, Alicia Comino Garcia-Muñoz, Teodora-Adriana Perles-Barbacaru, Abdechakour Elkihel, Wenzheng Zhang, Tom Roussel, Christina Galanakou, Jing Wu, Eleni Zerva, Nelson Dusetti, Yi Xia, Xing-Jie Liang, Angèle Viola, Juan L. Iovanna, Ling Peng
Publicado en: Science Advances, Edición 11, 2025, ISSN 2375-2548
Editor: American Association for the Advancement of Science (AAAS)
DOI: 10.1126/SCIADV.ADU9948

Hypoxic stress dysregulates functions of glioma-associated myeloid cells through epigenomic and transcriptional programs (se abrirá en una nueva ventana)

Autores: Monika Dzwigonska, Patrycja Rosa, Szymon Lipiec, Tomasz Obrebski, Gabriela Smyk, Beata Kaza, Salwador Cyranowski, Aleksandra Ellert-Miklaszewska, Agata Kominek, Anna R. Malik, Katarzyna Piwocka, Jakub Mieczkowski, Bozena Kaminska, Katarzyna B. Leszczynska
Publicado en: Cell Reports, Edición 44, 2025, ISSN 2211-1247
Editor: Elsevier BV
DOI: 10.1101/2024.09.12.612769V2

Elevated reactive oxygen species can drive the alternative lengthening of telomeres pathway in ATRX-null cancers (se abrirá en una nueva ventana)

Autores: Tomas Goncalves, Siobhan Cunniffe, Tiffany S Ma, Natalie Mattis, Andrew W Rose, Thomas Kent, David R Mole, Helene E B Geiller, Linda van Bijsterveldt, Timothy C Humphrey, Ester M Hammond, Richard J Gibbons, David Clynes, Anna M Rose
Publicado en: Nucleic Acids Research, Edición 53, 2025, ISSN 0305-1048
Editor: Oxford University Press (OUP)
DOI: 10.1093/NAR/GKAF061

Indolequinone-Based Hypoxia-Activated Proteolysis Targeting Chimeras Selectively Degrade BRD4 in Hypoxic Cancer Cells (se abrirá en una nueva ventana)

Autores: Marta Serafini, Sophie A. Twigger, George Delfas, Maxim Mallerman, Elliot P. Bailey, Ewen D. D. Calder, Ester M. Hammond, Stuart J. Conway
Publicado en: Journal of the American Chemical Society, 2025, ISSN 0002-7863
Editor: American Chemical Society (ACS)
DOI: 10.1021/JACS.5C10240

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