CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.
Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .
Resultado final
Systematic review of the ethical and legal state of discussion with respect to comorbidities and in particular interventions and their long-term effects on vulnerable and resilient populations.
Recommendations on ethical and legal considerations of COVID-19 - NDD comorbidity: paper manuscript (se abrirá en una nueva ventana)The LEAB and the work in WP5 have to result in tangible outcomes with respect to the planned recommender system (proof-of-concept) in WP3. A set of recommendations will be developed that guide the implementation and deployment (for test purposes) of the recommender system
Systematic testing of graph-based comorbidity hypotheses against data: paper manuscript describing methodology and outcome of Task 4.2 (se abrirá en una nueva ventana)The review mentioned in D4.1 will provide the literature basis for the systematic representation of major comorbidity hypotheses in cause-and-effect graphs. Pathophysiology graphs will be generated and tested against data (e.g. coming from clinical immune- / cytokine-assays) and concordance of the patterns in data with the graph-encoded pathophysiology mechanism will be tested. The paper manuscript will describe the results of these experiments.
Description of Data Management & Knowledge Graphs (se abrirá en una nueva ventana)Publication draft manuscript describing the COMMUTE knowledge base (based on NEO4J graph store) and the integration of heterogeneous knowledge graphs representing essential pathophysiology of COVID-19 and neurodegenerative diseases (AD and PD)
1st Workshop with LEAB and Patient Representatives (se abrirá en una nueva ventana)The workshops of the LEAB and patient representatives aim at bringing the viewpoint of the patients to the ethical and legal discussions in the LEAB. The workshops must be seen as a means of “grounding / rooting” of academic discussions
(Knowledge-based) Major comorbidity hypotheses reviewed review paper manuscript on major comorbidity hypotheses and their evidence in data and literature (se abrirá en una nueva ventana)Draft Review manuscript on the knowledge-based approach; which is hypothesis – driven. The potential and the limitations of test systems need to be addressed early-on in the project; we therefore will collect and represent systematically all major comorbidity hypotheses discussed in the literature. The manuscript that is the deliverable for D4.1 is a review of the major comorbidity hypotheses.
Communication and Dissemination plan (se abrirá en una nueva ventana)The project website will focus on making the project easily understandable. We will go for an event-based approach that triggers the community with dedicated campaigns for participation in workshops and performs consultations online. These information types will be found on the website; but the strongest focus will be on social media and dissemination via interactive forms of communication. The website is therefore more an archive as an active component of dissemination, as the main dissemination will be done via social media.
The DMP is a rather generic document, there are only little “project-specific” details in that DMP. Fundamental aspects such as FAIR or GDPR-compliance of patient-level data handling and -analytics are generic. The semantic templates for data interoperability are all published and fundamental methods of mapping and annotation will not change.
Publicaciones
Autores:
Ilya Mazein; Adrien Rougny; Alexander Mazein; Ron Henkel; Lea Gütebier; Lea Michaelis; Marek Ostaszewski; Reinhard Schneider; Venkata Satagopam; Lars Juhl Jensen; Dagmar Waltemath; Judith A H Wodke; Irina Balaur
Publicado en:
Briefings in Bioinformatics, 2024
Editor:
Oxford University Press
DOI:
10.1093/BIB/BBAE561
Autores:
Anett Hudák; Dávid Pusztai; Annamária Letoha; Tamás Letoha
Publicado en:
International Journal of Molecular Sciences, 2024, ISSN 1422-0067
Editor:
Multidisciplinary Digital Publishing Institute (MDPI)
DOI:
10.3390/IJMS25147534
Autores:
Dimitrii Pogorelov; Sebastian Felix Nepomuk Bode; Xin He; Javier Ramiro-Garcia; Fanny Hedin; Wim Ammerlaan; Maria Konstantinou; Christophe M. Capelle; Ni Zeng; Aurélie Poli; Olivia Domingues; Guillem Montamat; Oliver Hunewald; Séverine Ciré; Alexandre Baron; Joseph Longworth; Agnieszka Demczuk; Murilo Luiz Bazon; Ingrid Casper; Ludger Klimek; Lorie Neuberger-Castillo; Dominique Revets; Lea Guyonnet; Sylvie Delhalle; Jacques Zimmer; Vladimir Benes; Françoise Codreanu-Morel; Christiane Lehners-Weber; Ilse Weets; Pinar Alper; Dirk Brenner; Jan Gutermuth; Coralie Guerin; Martine Morisset; François Hentges; Reinhard Schneider; Mohamed H. Shamji; Fay Betsou; Paul Wilmes; Enrico Glaab; Antonio Cosma; Jorge Goncalves; Feng Q. Hefeng; Markus Ollert
Publicado en:
Nature Communications, 2024, ISSN 2041-1723
Editor:
Nature Publishing Group
DOI:
10.1038/S41467-024-54684-2
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