Report on review of current state of ethical and legal discussion with respect to non-curable AD and PD
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Systematic review of the ethical and legal state of discussion with respect to comorbidities and in particular interventions and their long-term effects on vulnerable and resilient populations.
Recommendations on ethical and legal considerations of COVID-19 - NDD comorbidity: paper manuscript
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The LEAB and the work in WP5 have to result in tangible outcomes with respect to the planned recommender system (proof-of-concept) in WP3. A set of recommendations will be developed that guide the implementation and deployment (for test purposes) of the recommender system
Systematic testing of graph-based comorbidity hypotheses against data: paper manuscript describing methodology and outcome of Task 4.2
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The review mentioned in D4.1 will provide the literature basis for the systematic representation of major comorbidity hypotheses in cause-and-effect graphs. Pathophysiology graphs will be generated and tested against data (e.g. coming from clinical immune- / cytokine-assays) and concordance of the patterns in data with the graph-encoded pathophysiology mechanism will be tested. The paper manuscript will describe the results of these experiments.
Description of Data Management & Knowledge Graphs
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Publication draft manuscript describing the COMMUTE knowledge base (based on NEO4J graph store) and the integration of heterogeneous knowledge graphs representing essential pathophysiology of COVID-19 and neurodegenerative diseases (AD and PD)
1st Workshop with LEAB and Patient Representatives
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The workshops of the LEAB and patient representatives aim at bringing the viewpoint of the patients to the ethical and legal discussions in the LEAB. The workshops must be seen as a means of “grounding / rooting” of academic discussions
(Knowledge-based) Major comorbidity hypotheses reviewed review paper manuscript on major comorbidity hypotheses and their evidence in data and literature
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Draft Review manuscript on the knowledge-based approach; which is hypothesis – driven. The potential and the limitations of test systems need to be addressed early-on in the project; we therefore will collect and represent systematically all major comorbidity hypotheses discussed in the literature. The manuscript that is the deliverable for D4.1 is a review of the major comorbidity hypotheses.
Communication and Dissemination plan
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The project website will focus on making the project easily understandable. We will go for an event-based approach that triggers the community with dedicated campaigns for participation in workshops and performs consultations online. These information types will be found on the website; but the strongest focus will be on social media and dissemination via interactive forms of communication. The website is therefore more an archive as an active component of dissemination, as the main dissemination will be done via social media.
