Periodic Reporting for period 1 - NextGen (NEXT GENERATION TOOLS FOR GENOME-CENTRIC MULTIMODAL DATA INTEGRATION IN PERSONALISED CARDIOVASCULAR MEDICINE)
Reporting period: 2024-01-01 to 2025-06-30
The overall objective of NextGen is to build novel and synergistic tools to enable portable multimodal, multiomic and clinically-oriented research in high-impact areas of cardiovascular medicine. NextGen tools will benefit researchers, innovators and healthcare professionals by identifying and overcoming health data linkage barriers in exemplar use cases which are complex or intractable with existing technology. Consequently, it will benefit patients, providing faster diagnosis, and better treatments (including personalised medicine). A comprehensive gap analysis of the existing landscape, factoring in ongoing initiatives will ensure NextGen deliverables are forward-looking and complementary. In particular, the NextGen embedded governance framework and robust regulatory processes will ensure secure multi-jurisdictional phenotype and genomic data access aligned with initiatives including “1+ Million Genomes” and European Health Data Space.
The project remains on track. Significant progress has been made in decentralized data management, architecture design, federated analytics, multimodal integration, governance, and stakeholder engagement. Pathfinder and MVP services have been deployed, laying the foundation for cross-jurisdictional interoperability, privacy-preserving data sharing, and sustainable exploitation of project results.