The role of an Epstein-Barr virus infection in the pathogenesis of multiple sclerosis

Project Information

BEHIND-MS

Grant agreement ID: 101137235

DOI

10.3030/101137235

EC signature date 13 November 2023

Start date 1 December 2023

End date 30 November 2028

Funded under

• Health

Total cost

€ 7 550 708,75

EU contribution

€ 7 550 708,75

Coordinated by

DEUTSCHES KREBSFORSCHUNGSZENTRUM HEIDELBERG
Germany

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Websites, patent fillings, videos etc. (1)

BEHIND-MS visual identity and website

A project logo and identity design will be developed by M4. The website, constituting the central hub for BEHIND-MS’ communication and dissemination, will be developed by M6 and hosted and maintained by CNR, while all partners will contribute to the content.

Publications

Peer reviewed articles (12)

Increased EBNA1-specific antibody response in primary-progressive multiple sclerosis

Author(s): Manuel Comabella, Harald Hegen, Luisa M. Villar, Konrad Rejdak, Augusto Sao-Avilés, Malina Behrens, Jaume Sastre-Garriga, Neus Mongay, Klaus Berek, Sergio Martínez-Yelamos, Francisco Pérez-Miralles, Ahmed Abdelhak, Franziska Bachhuber, Hayrettin Tumani, Jan Lycke, Pere Carbonell-Mirabent, Adrián Valls-Carbó, Igal Rosenstein, Roberto Alvarez-Lafuente, Tamara Castillo-Triviño, David Otaegui, Sara Llufriu, Yolanda Blanco, Antonio J. Sánchez-López, Antonio García-Merino, Nicolás Fissolo, Lucía Gutiérrez, Javier Villacieros-Álvarez, Enric Monreal, Heinz Wiendl, Xavier Montalban, Jan D. Lünemann
Published in: Journal of Neurology, Issue 272, 2024, ISSN 0340-5354
Publisher: Springer Science and Business Media LLC
DOI: 10.1007/s00415-024-12763-w

EBV infection and HLA-DR15 jointly drive multiple sclerosis by myelin peptide presentation

Author(s): Jian Wang, Yuhan Qiu, Zoe Marti, Fengqi Li, Marcel Wacker, Pietro Oldrati, Lena Mühlenbruch, Linlin Jin, Hongxia Zhang, Wen Xu, Tingting Li, Bernd Roschitzki, Wolfgang Faigle, Yingjun Liu, Julie T. Nguyen, Jar-How Lee, Veronika Haunerdinger, Mathias Hauri-Hohl, Frank Momburg, Jens Bauer, Hans-Georg Rammensee, Mireia Sospedra, Roberta Magliozzi, Richard Reynolds, Juliane Walz, Roland Martin
Published in: Cell, Issue 189, 2026, ISSN 0092-8674
Publisher: Elsevier BV
DOI: 10.1016/J.CELL.2025.12.046

EBV induces CNS homing of B cells attracting inflammatory T cells

Author(s): Fabienne Läderach, Ioannis Piteros, Éanna Fennell, Elena Bremer, Mette Last, Sandra Schmid, Lisa Rieble, Caroline Campbell, Isis Ludwig-Portugall, Lea Bornemann, Alexander Gruhl, Klaus Eulitz, Paul Gueguen, Juliane Mietz, Anne Müller, Gaetana Pezzino, Jürgen Schmitz, Guido Ferlazzo, Josef Mautner, Christian Münz
Published in: Nature, Issue 646, 2025, ISSN 0028-0836
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/S41586-025-09378-0

Epstein–Barr virus induces aberrant B cell migration and diapedesis via FAK-dependent chemotaxis pathways

Author(s): Susanne Delecluse, Francesco Baccianti, Manon Zala, Alina Steffens, Carolin Drenda, Daniel Judt, Tim Holland-Letz, Remy Poirey, Pierre Sujobert, Henri-Jacques Delecluse
Published in: Nature Communications, Issue 16, 2025, ISSN 2041-1723
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/S41467-025-59813-Z

EBV Early Lytic Antigens, EBNA2 and PDL-1, in Progressive Multiple Sclerosis Brain: A Coordinated Contribution to Viral Immune Evasion

Author(s): Lucia Benincasa, Barbara Rosicarelli, Chiara Meloni, Barbara Serafini
Published in: International Journal of Molecular Sciences, Issue 27, 2025, ISSN 1422-0067
Publisher: MDPI AG
DOI: 10.3390/IJMS27010437

Altered EBV specific immune control in multiple sclerosis

Author(s): Christian Münz
Published in: Journal of Neuroimmunology, Issue 390, 2024, ISSN 0165-5728
Publisher: Elsevier BV
DOI: 10.1016/J.JNEUROIM.2024.578343

EBV-specific T-cell immunity: relevance for multiple sclerosis

Author(s): Malina Behrens, Manuel Comabella, Jan D. Lünemann
Published in: Frontiers in Immunology, Issue 15, 2024, ISSN 1664-3224
Publisher: Frontiers Media SA
DOI: 10.3389/FIMMU.2024.1509927

Epstein–Barr virus pathogenesis and emerging control strategies

Author(s): Christian Münz
Published in: Nature Reviews Microbiology, 2025, ISSN 1740-1526
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/S41579-025-01181-Y

EBV Dysregulation Is Associated With Immune Imbalance in Multiple Sclerosis

Author(s): Chiara Meloni, Fabiana Marnetto, Corrado Fagnani, Lucia Benincasa, Diletta Galano, Pankaj Trivedi, Paola Valentino, Serena Martire, Alessia Di Sapio, Antonio Bertolotto, Anna Maria Repice, Clara Ballerini, Cristina Mancosu, Jessica Frau, Eleonora Cocco, Caterina Veroni
Published in: Neurology Neuroimmunology & Neuroinflammation, Issue 13, 2026, ISSN 2332-7812
Publisher: Ovid Technologies (Wolters Kluwer Health)
DOI: 10.1212/NXI.0000000000200545

Multiple sclerosis-associated EBNA2 variants influence the response to peginterferon beta-1a therapy

Author(s): Caterina Veroni, Fortunata Carbone, Daniela Ricci, Stefania Proietti, Silvia Romano, Maria Chiara Buscarinu, Fabiana Rizzo, Antonio Marrone, Teresa Micillo, Francesco Perna, Federica Garziano, Gisella Guerrera, Paola Valentino, Chiara Meloni, Gianmarco Bellucci, Antonio Bertolotto, Luca Battistini, Giovanni Ristori, Diego Centonze, Giuseppe Matarese, Eliana M. Coccia, Marco Salvetti, Martina Severa, Rosella Mechelli
Published in: Journal of Autoimmunity, Issue 159, 2026, ISSN 0896-8411
Publisher: Elsevier BV
DOI: 10.1016/J.JAUT.2026.103533

Recent advances in animal models of lymphomagenesis caused by human γ-herpesviruses

Author(s): Christian Münz
Published in: Current Opinion in Virology, Issue 71, 2025, ISSN 1879-6257
Publisher: Elsevier BV
DOI: 10.1016/J.COVIRO.2025.101461

Integrin β1 Demarks Precursors of Brain-Residing Antibody-Secreting Cells in Multiple Sclerosis

Author(s): Kirsten L. Kuiper, Laurens Bogers, Jasper Rip, Yifan van Hasselt, Marie-José Melief, Annet F. Wierenga-Wolf, Romy A.M. Klein Kranenbarg, Eric Bindels, Harmen J.G. van de Werken, Janet de Beukelaar, Ide Smets, Beatrijs Wokke, Joost Smolders, Marvin M. van Luijn
Published in: Neurology Neuroimmunology & Neuroinflammation, Issue 13, 2026, ISSN 2332-7812
Publisher: Ovid Technologies (Wolters Kluwer Health)
DOI: 10.1212/NXI.0000000000200553