The role of an Epstein-Barr virus infection in the pathogenesis of multiple sclerosis

Información del proyecto

BEHIND-MS

Identificador del acuerdo de subvención: 101137235

DOI

10.3030/101137235

Fecha de la firma de la CE 13 Noviembre 2023

Fecha de inicio 1 Diciembre 2023

Fecha de finalización 30 Noviembre 2028

Financiado con arreglo a

• Health

Coste total

€ 7 550 708,75

Aportación de la UE

€ 7 550 708,75

Coordinado por

DEUTSCHES KREBSFORSCHUNGSZENTRUM HEIDELBERG
Germany

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Websites, patent fillings, videos etc. (1)

BEHIND-MS visual identity and website

A project logo and identity design will be developed by M4. The website, constituting the central hub for BEHIND-MS’ communication and dissemination, will be developed by M6 and hosted and maintained by CNR, while all partners will contribute to the content.

Publicaciones

Peer reviewed articles (19)

Multiple sclerosis-associated HLA demarcates EBV-specific CD8+ T cells with an exhausted and brain residency phenotype

Autores: Sanne Reijm, Ana M. Marques, Jasper Rip, Cato E.A. Corsten, Annet F. Wierenga-Wolf, Harm de Wit, Marie-José Melief, Yifan van Hasselt, Jamie van Langelaar, Rinze Neuteboom, Beatrijs H.A. Wokke, Yvonne M. Mueller, Joost Smolders, Marvin M. van Luijn
Publicado en: iScience, Edición 29, 2026, ISSN 2589-0042
Editor: Elsevier BV
DOI: 10.1016/J.ISCI.2026.115744

Increased EBNA1-specific antibody response in primary-progressive multiple sclerosis

Autores: Manuel Comabella, Harald Hegen, Luisa M. Villar, Konrad Rejdak, Augusto Sao-Avilés, Malina Behrens, Jaume Sastre-Garriga, Neus Mongay, Klaus Berek, Sergio Martínez-Yelamos, Francisco Pérez-Miralles, Ahmed Abdelhak, Franziska Bachhuber, Hayrettin Tumani, Jan Lycke, Pere Carbonell-Mirabent, Adrián Valls-Carbó, Igal Rosenstein, Roberto Alvarez-Lafuente, Tamara Castillo-Triviño, David Otaegui, Sara Llufriu, Yolanda Blanco, Antonio J. Sánchez-López, Antonio García-Merino, Nicolás Fissolo, Lucía Gutiérrez, Javier Villacieros-Álvarez, Enric Monreal, Heinz Wiendl, Xavier Montalban, Jan D. Lünemann
Publicado en: Journal of Neurology, Edición 272, 2024, ISSN 0340-5354
Editor: Springer Science and Business Media LLC
DOI: 10.1007/s00415-024-12763-w

EBV infection and HLA-DR15 jointly drive multiple sclerosis by myelin peptide presentation

Autores: Jian Wang, Yuhan Qiu, Zoe Marti, Fengqi Li, Marcel Wacker, Pietro Oldrati, Lena Mühlenbruch, Linlin Jin, Hongxia Zhang, Wen Xu, Tingting Li, Bernd Roschitzki, Wolfgang Faigle, Yingjun Liu, Julie T. Nguyen, Jar-How Lee, Veronika Haunerdinger, Mathias Hauri-Hohl, Frank Momburg, Jens Bauer, Hans-Georg Rammensee, Mireia Sospedra, Roberta Magliozzi, Richard Reynolds, Juliane Walz, Roland Martin
Publicado en: Cell, Edición 189, 2026, ISSN 0092-8674
Editor: Elsevier BV
DOI: 10.1016/J.CELL.2025.12.046

Neuroinflammation as a result of non‐neurotropic herpesvirus infection

Autores: Christian Münz
Publicado en: Immunology & Cell Biology, Edición 104, 2026, ISSN 0818-9641
Editor: Wiley
DOI: 10.1111/IMCB.70108

EBV induces CNS homing of B cells attracting inflammatory T cells

Autores: Fabienne Läderach, Ioannis Piteros, Éanna Fennell, Elena Bremer, Mette Last, Sandra Schmid, Lisa Rieble, Caroline Campbell, Isis Ludwig-Portugall, Lea Bornemann, Alexander Gruhl, Klaus Eulitz, Paul Gueguen, Juliane Mietz, Anne Müller, Gaetana Pezzino, Jürgen Schmitz, Guido Ferlazzo, Josef Mautner, Christian Münz
Publicado en: Nature, Edición 646, 2025, ISSN 0028-0836
Editor: Springer Science and Business Media LLC
DOI: 10.1038/S41586-025-09378-0

Acta neuropathologica communications

Autores: Engelenburg, Hendrik J; Westenbrink, Esmée; Runderkamp, Eline; Marques, Ana M; van Luijn, Marvin M; Hsiao, Cheng-Chih; Huitinga, Inge; Hamann, Jörg; Smolders, Joost
Publicado en: Acta Neuropathologica Communications, 2026, ISSN 2051-5960
Editor: BioMed Central
DOI: 10.1186/S40478-025-02208-4

Epstein–Barr virus induces aberrant B cell migration and diapedesis via FAK-dependent chemotaxis pathways

Autores: Susanne Delecluse, Francesco Baccianti, Manon Zala, Alina Steffens, Carolin Drenda, Daniel Judt, Tim Holland-Letz, Remy Poirey, Pierre Sujobert, Henri-Jacques Delecluse
Publicado en: Nature Communications, Edición 16, 2025, ISSN 2041-1723
Editor: Springer Science and Business Media LLC
DOI: 10.1038/S41467-025-59813-Z

A novel multiplex approach for the comprehensive analysis of the Epstein-Barr virus-specific humoral immune response

Autores: Carola Meindl, Ramona Weggel, Karolin Deichl, Kathrin Maria Fleischer, Paula Hofmeier, Mette Last, Julius Nückel, Elisa Planatscher, Lobna Ali Onsi, Anna Schütt, Uta Behrends, Josef Mautner
Publicado en: Frontiers in Cellular and Infection Microbiology, Edición 16, 2026, ISSN 2235-2988
Editor: Frontiers Media SA
DOI: 10.3389/FCIMB.2026.1829807

EBV Early Lytic Antigens, EBNA2 and PDL-1, in Progressive Multiple Sclerosis Brain: A Coordinated Contribution to Viral Immune Evasion

Autores: Lucia Benincasa, Barbara Rosicarelli, Chiara Meloni, Barbara Serafini
Publicado en: International Journal of Molecular Sciences, Edición 27, 2025, ISSN 1422-0067
Editor: MDPI AG
DOI: 10.3390/IJMS27010437

Altered EBV specific immune control in multiple sclerosis

Autores: Christian Münz
Publicado en: Journal of Neuroimmunology, Edición 390, 2024, ISSN 0165-5728
Editor: Elsevier BV
DOI: 10.1016/J.JNEUROIM.2024.578343

EBV-specific T-cell immunity: relevance for multiple sclerosis

Autores: Malina Behrens, Manuel Comabella, Jan D. Lünemann
Publicado en: Frontiers in Immunology, Edición 15, 2024, ISSN 1664-3224
Editor: Frontiers Media SA
DOI: 10.3389/FIMMU.2024.1509927

Epstein–Barr virus pathogenesis and emerging control strategies

Autores: Christian Münz
Publicado en: Nature Reviews Microbiology, 2025, ISSN 1740-1526
Editor: Springer Science and Business Media LLC
DOI: 10.1038/S41579-025-01181-Y

EBV Dysregulation Is Associated With Immune Imbalance in Multiple Sclerosis

Autores: Chiara Meloni, Fabiana Marnetto, Corrado Fagnani, Lucia Benincasa, Diletta Galano, Pankaj Trivedi, Paola Valentino, Serena Martire, Alessia Di Sapio, Antonio Bertolotto, Anna Maria Repice, Clara Ballerini, Cristina Mancosu, Jessica Frau, Eleonora Cocco, Caterina Veroni
Publicado en: Neurology Neuroimmunology & Neuroinflammation, Edición 13, 2026, ISSN 2332-7812
Editor: Ovid Technologies (Wolters Kluwer Health)
DOI: 10.1212/NXI.0000000000200545

Multiple sclerosis-associated EBNA2 variants influence the response to peginterferon beta-1a therapy

Autores: Caterina Veroni, Fortunata Carbone, Daniela Ricci, Stefania Proietti, Silvia Romano, Maria Chiara Buscarinu, Fabiana Rizzo, Antonio Marrone, Teresa Micillo, Francesco Perna, Federica Garziano, Gisella Guerrera, Paola Valentino, Chiara Meloni, Gianmarco Bellucci, Antonio Bertolotto, Luca Battistini, Giovanni Ristori, Diego Centonze, Giuseppe Matarese, Eliana M. Coccia, Marco Salvetti, Martina Severa, Rosella Mechelli
Publicado en: Journal of Autoimmunity, Edición 159, 2026, ISSN 0896-8411
Editor: Elsevier BV
DOI: 10.1016/J.JAUT.2026.103533

Genetic and environmental mediators of multiple sclerosis susceptibility but not early severity run in families

Autores: Cato E.A. Corsten, Ana M. Marques, Yifan van Hasselt, Jeroen van Rooij, Ide Smets, Marvin M. van Luijn, Rinze F. Neuteboom, Beatrijs Wokke, Joost Smolders
Publicado en: Multiple Sclerosis and Related Disorders, Edición 109, 2026, ISSN 2211-0348
Editor: Elsevier BV
DOI: 10.1016/J.MSARD.2026.107101

Recent advances in animal models of lymphomagenesis caused by human γ-herpesviruses

Autores: Christian Münz
Publicado en: Current Opinion in Virology, Edición 71, 2025, ISSN 1879-6257
Editor: Elsevier BV
DOI: 10.1016/J.COVIRO.2025.101461

Integrin β1 Demarks Precursors of Brain-Residing Antibody-Secreting Cells in Multiple Sclerosis

Autores: Kirsten L. Kuiper, Laurens Bogers, Jasper Rip, Yifan van Hasselt, Marie-José Melief, Annet F. Wierenga-Wolf, Romy A.M. Klein Kranenbarg, Eric Bindels, Harmen J.G. van de Werken, Janet de Beukelaar, Ide Smets, Beatrijs Wokke, Joost Smolders, Marvin M. van Luijn
Publicado en: Neurology Neuroimmunology & Neuroinflammation, Edición 13, 2026, ISSN 2332-7812
Editor: Ovid Technologies (Wolters Kluwer Health)
DOI: 10.1212/NXI.0000000000200553

Triggering multiple sclerosis: infection with Epstein-Barr virus activates multiple pre-existing autoreactive B and T cells

Autores: Edgar Meinl, Christian Münz
Publicado en: Signal Transduction and Targeted Therapy, Edición 11, 2026, ISSN 2059-3635
Editor: Springer Science and Business Media LLC
DOI: 10.1038/S41392-026-02684-7

Latent, Lytic, and Linked to Multiple Sclerosis—How EBV Drives Autoimmunity

Autores: Fabienne Läderach, Elena Bremer, Christian Münz
Publicado en: European Journal of Immunology, Edición 56, 2026, ISSN 0014-2980
Editor: Wiley
DOI: 10.1002/EJI.70153