The role of an Epstein-Barr virus infection in the pathogenesis of multiple sclerosis

Informazioni relative al progetto

BEHIND-MS

ID dell’accordo di sovvenzione: 101137235

DOI

10.3030/101137235

Data della firma CE 13 Novembre 2023

Data di avvio 1 Dicembre 2023

Data di completamento 30 Novembre 2028

Finanziato da

• Health

Costo totale

€ 7 550 708,75

Contributo UE

€ 7 550 708,75

Coordinato da

DEUTSCHES KREBSFORSCHUNGSZENTRUM HEIDELBERG
Germany

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Websites, patent fillings, videos etc. (1)

BEHIND-MS visual identity and website

A project logo and identity design will be developed by M4. The website, constituting the central hub for BEHIND-MS’ communication and dissemination, will be developed by M6 and hosted and maintained by CNR, while all partners will contribute to the content.

Pubblicazioni

Peer reviewed articles (19)

Multiple sclerosis-associated HLA demarcates EBV-specific CD8+ T cells with an exhausted and brain residency phenotype

Autori: Sanne Reijm, Ana M. Marques, Jasper Rip, Cato E.A. Corsten, Annet F. Wierenga-Wolf, Harm de Wit, Marie-José Melief, Yifan van Hasselt, Jamie van Langelaar, Rinze Neuteboom, Beatrijs H.A. Wokke, Yvonne M. Mueller, Joost Smolders, Marvin M. van Luijn
Pubblicato in: iScience, Numero 29, 2026, ISSN 2589-0042
Editore: Elsevier BV
DOI: 10.1016/J.ISCI.2026.115744

Increased EBNA1-specific antibody response in primary-progressive multiple sclerosis

Autori: Manuel Comabella, Harald Hegen, Luisa M. Villar, Konrad Rejdak, Augusto Sao-Avilés, Malina Behrens, Jaume Sastre-Garriga, Neus Mongay, Klaus Berek, Sergio Martínez-Yelamos, Francisco Pérez-Miralles, Ahmed Abdelhak, Franziska Bachhuber, Hayrettin Tumani, Jan Lycke, Pere Carbonell-Mirabent, Adrián Valls-Carbó, Igal Rosenstein, Roberto Alvarez-Lafuente, Tamara Castillo-Triviño, David Otaegui, Sara Llufriu, Yolanda Blanco, Antonio J. Sánchez-López, Antonio García-Merino, Nicolás Fissolo, Lucía Gutiérrez, Javier Villacieros-Álvarez, Enric Monreal, Heinz Wiendl, Xavier Montalban, Jan D. Lünemann
Pubblicato in: Journal of Neurology, Numero 272, 2024, ISSN 0340-5354
Editore: Springer Science and Business Media LLC
DOI: 10.1007/s00415-024-12763-w

EBV infection and HLA-DR15 jointly drive multiple sclerosis by myelin peptide presentation

Autori: Jian Wang, Yuhan Qiu, Zoe Marti, Fengqi Li, Marcel Wacker, Pietro Oldrati, Lena Mühlenbruch, Linlin Jin, Hongxia Zhang, Wen Xu, Tingting Li, Bernd Roschitzki, Wolfgang Faigle, Yingjun Liu, Julie T. Nguyen, Jar-How Lee, Veronika Haunerdinger, Mathias Hauri-Hohl, Frank Momburg, Jens Bauer, Hans-Georg Rammensee, Mireia Sospedra, Roberta Magliozzi, Richard Reynolds, Juliane Walz, Roland Martin
Pubblicato in: Cell, Numero 189, 2026, ISSN 0092-8674
Editore: Elsevier BV
DOI: 10.1016/J.CELL.2025.12.046

Neuroinflammation as a result of non‐neurotropic herpesvirus infection

Autori: Christian Münz
Pubblicato in: Immunology & Cell Biology, Numero 104, 2026, ISSN 0818-9641
Editore: Wiley
DOI: 10.1111/IMCB.70108

EBV induces CNS homing of B cells attracting inflammatory T cells

Autori: Fabienne Läderach, Ioannis Piteros, Éanna Fennell, Elena Bremer, Mette Last, Sandra Schmid, Lisa Rieble, Caroline Campbell, Isis Ludwig-Portugall, Lea Bornemann, Alexander Gruhl, Klaus Eulitz, Paul Gueguen, Juliane Mietz, Anne Müller, Gaetana Pezzino, Jürgen Schmitz, Guido Ferlazzo, Josef Mautner, Christian Münz
Pubblicato in: Nature, Numero 646, 2025, ISSN 0028-0836
Editore: Springer Science and Business Media LLC
DOI: 10.1038/S41586-025-09378-0

Acta neuropathologica communications

Autori: Engelenburg, Hendrik J; Westenbrink, Esmée; Runderkamp, Eline; Marques, Ana M; van Luijn, Marvin M; Hsiao, Cheng-Chih; Huitinga, Inge; Hamann, Jörg; Smolders, Joost
Pubblicato in: Acta Neuropathologica Communications, 2026, ISSN 2051-5960
Editore: BioMed Central
DOI: 10.1186/S40478-025-02208-4

Epstein–Barr virus induces aberrant B cell migration and diapedesis via FAK-dependent chemotaxis pathways

Autori: Susanne Delecluse, Francesco Baccianti, Manon Zala, Alina Steffens, Carolin Drenda, Daniel Judt, Tim Holland-Letz, Remy Poirey, Pierre Sujobert, Henri-Jacques Delecluse
Pubblicato in: Nature Communications, Numero 16, 2025, ISSN 2041-1723
Editore: Springer Science and Business Media LLC
DOI: 10.1038/S41467-025-59813-Z

A novel multiplex approach for the comprehensive analysis of the Epstein-Barr virus-specific humoral immune response

Autori: Carola Meindl, Ramona Weggel, Karolin Deichl, Kathrin Maria Fleischer, Paula Hofmeier, Mette Last, Julius Nückel, Elisa Planatscher, Lobna Ali Onsi, Anna Schütt, Uta Behrends, Josef Mautner
Pubblicato in: Frontiers in Cellular and Infection Microbiology, Numero 16, 2026, ISSN 2235-2988
Editore: Frontiers Media SA
DOI: 10.3389/FCIMB.2026.1829807

EBV Early Lytic Antigens, EBNA2 and PDL-1, in Progressive Multiple Sclerosis Brain: A Coordinated Contribution to Viral Immune Evasion

Autori: Lucia Benincasa, Barbara Rosicarelli, Chiara Meloni, Barbara Serafini
Pubblicato in: International Journal of Molecular Sciences, Numero 27, 2025, ISSN 1422-0067
Editore: MDPI AG
DOI: 10.3390/IJMS27010437

Altered EBV specific immune control in multiple sclerosis

Autori: Christian Münz
Pubblicato in: Journal of Neuroimmunology, Numero 390, 2024, ISSN 0165-5728
Editore: Elsevier BV
DOI: 10.1016/J.JNEUROIM.2024.578343

EBV-specific T-cell immunity: relevance for multiple sclerosis

Autori: Malina Behrens, Manuel Comabella, Jan D. Lünemann
Pubblicato in: Frontiers in Immunology, Numero 15, 2024, ISSN 1664-3224
Editore: Frontiers Media SA
DOI: 10.3389/FIMMU.2024.1509927

Epstein–Barr virus pathogenesis and emerging control strategies

Autori: Christian Münz
Pubblicato in: Nature Reviews Microbiology, 2025, ISSN 1740-1526
Editore: Springer Science and Business Media LLC
DOI: 10.1038/S41579-025-01181-Y

EBV Dysregulation Is Associated With Immune Imbalance in Multiple Sclerosis

Autori: Chiara Meloni, Fabiana Marnetto, Corrado Fagnani, Lucia Benincasa, Diletta Galano, Pankaj Trivedi, Paola Valentino, Serena Martire, Alessia Di Sapio, Antonio Bertolotto, Anna Maria Repice, Clara Ballerini, Cristina Mancosu, Jessica Frau, Eleonora Cocco, Caterina Veroni
Pubblicato in: Neurology Neuroimmunology & Neuroinflammation, Numero 13, 2026, ISSN 2332-7812
Editore: Ovid Technologies (Wolters Kluwer Health)
DOI: 10.1212/NXI.0000000000200545

Multiple sclerosis-associated EBNA2 variants influence the response to peginterferon beta-1a therapy

Autori: Caterina Veroni, Fortunata Carbone, Daniela Ricci, Stefania Proietti, Silvia Romano, Maria Chiara Buscarinu, Fabiana Rizzo, Antonio Marrone, Teresa Micillo, Francesco Perna, Federica Garziano, Gisella Guerrera, Paola Valentino, Chiara Meloni, Gianmarco Bellucci, Antonio Bertolotto, Luca Battistini, Giovanni Ristori, Diego Centonze, Giuseppe Matarese, Eliana M. Coccia, Marco Salvetti, Martina Severa, Rosella Mechelli
Pubblicato in: Journal of Autoimmunity, Numero 159, 2026, ISSN 0896-8411
Editore: Elsevier BV
DOI: 10.1016/J.JAUT.2026.103533

Genetic and environmental mediators of multiple sclerosis susceptibility but not early severity run in families

Autori: Cato E.A. Corsten, Ana M. Marques, Yifan van Hasselt, Jeroen van Rooij, Ide Smets, Marvin M. van Luijn, Rinze F. Neuteboom, Beatrijs Wokke, Joost Smolders
Pubblicato in: Multiple Sclerosis and Related Disorders, Numero 109, 2026, ISSN 2211-0348
Editore: Elsevier BV
DOI: 10.1016/J.MSARD.2026.107101

Recent advances in animal models of lymphomagenesis caused by human γ-herpesviruses

Autori: Christian Münz
Pubblicato in: Current Opinion in Virology, Numero 71, 2025, ISSN 1879-6257
Editore: Elsevier BV
DOI: 10.1016/J.COVIRO.2025.101461

Integrin β1 Demarks Precursors of Brain-Residing Antibody-Secreting Cells in Multiple Sclerosis

Autori: Kirsten L. Kuiper, Laurens Bogers, Jasper Rip, Yifan van Hasselt, Marie-José Melief, Annet F. Wierenga-Wolf, Romy A.M. Klein Kranenbarg, Eric Bindels, Harmen J.G. van de Werken, Janet de Beukelaar, Ide Smets, Beatrijs Wokke, Joost Smolders, Marvin M. van Luijn
Pubblicato in: Neurology Neuroimmunology & Neuroinflammation, Numero 13, 2026, ISSN 2332-7812
Editore: Ovid Technologies (Wolters Kluwer Health)
DOI: 10.1212/NXI.0000000000200553

Triggering multiple sclerosis: infection with Epstein-Barr virus activates multiple pre-existing autoreactive B and T cells

Autori: Edgar Meinl, Christian Münz
Pubblicato in: Signal Transduction and Targeted Therapy, Numero 11, 2026, ISSN 2059-3635
Editore: Springer Science and Business Media LLC
DOI: 10.1038/S41392-026-02684-7

Latent, Lytic, and Linked to Multiple Sclerosis—How EBV Drives Autoimmunity

Autori: Fabienne Läderach, Elena Bremer, Christian Münz
Pubblicato in: European Journal of Immunology, Numero 56, 2026, ISSN 0014-2980
Editore: Wiley
DOI: 10.1002/EJI.70153