The ESCORT project addresses one of the most pressing challenges facing European healthcare systems: ensuring resilience, efficiency, and continuity of care during crises while advancing the digital transformation of routine services. The COVID-19 pandemic, rising natural disasters, and increased cross-border mobility have exposed vulnerabilities such as unplanned patient surges, fragmentation between primary and social care, and weak coordination with emergency medical units. ESCORT responds by bringing together healthcare providers from six countries (Greece, Italy, Belgium, Ireland, Sweden, Israel), SMEs, industry, and research organisations to co-design and deploy digital health tools. Innovations include an AI-powered integrated healthcare system with smart handheld devices for emergency personnel and patients, telemedicine platforms for proactive interventions, and the integration of IoT, wearables, and edge devices to create interoperable, patient-centred services. The project’s pathway to impact combines evidence gathering (systematic reviews, user requirements, demand forecasting), technical innovation (AI algorithms, data integration, mobile apps, telemedicine), and pilot validation across six national contexts. These activities will generate actionable insights and deployable tools to strengthen resilience, improve surge management, and support cross-border services. Expected impacts are significant: reducing service disruptions during crises, improving patient experience and safety, optimising resources, and enabling long-term policy planning through AI-enabled modelling. ESCORT aligns with EU health priorities, including the European Health Data Space (EHDS) and Digital Europe Programme, while addressing the World Health Organization’s call for resilient, digitally empowered health systems. The integration of social sciences and humanities (SSH) is central: SSH experts contribute to co-design, ethics-by-design, and stakeholder consultations. Patient advocacy forums, workshops, and persona-driven design ensure ESCORT’s innovations remain inclusive, ethical, and aligned with human needs.