Multidimensional Integrated Quantitative Approach To Assess Safety And Sustainability Of Nanomaterials In Real Case Life Cycle Scenarios Using Nanospecific Impact Categories

Project Information

INTEGRANO

Grant agreement ID: 101138414

DOI

10.3030/101138414

EC signature date 23 November 2023

Start date 1 January 2024

End date 31 December 2027

Funded under

• Digital, Industry and Space

Total cost

€ 4 140 133,35

EU contribution

€ 3 985 648,75

Coordinated by

UNIVERSITA' DEGLI STUDI DI MILANO-BICOCCA
Italy

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Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Websites, patent fillings, videos etc. (2)

IT platform for stakeholders engagement - SSbD Think tank
Project visual identity and website.

Documents, reports (2)

Final data management Plan
First data management Plan

Data management Plan

Publications

Peer reviewed articles (10)

Comparative toxicity and environmental impact assessments of sonochemically-synthesized CuO and Zn-doped CuO nanoparticles using zebrafish and LCA tools

Author(s): Beatrice Negrini; Pamela Floris; Christian D’Abramo; Seyed Ahmad Aldaghi; Mattia Costamagna; Massimo Perucca; Melissa Saibene; Ilana Perelshtein; Anita Colombo; Patrizia Bonfanti; Paride Mantecca
Published in: Discover Nano, Issue Volume 20, article number 51, 2025, ISSN 2731-9229
Publisher: Discover Nano
DOI: 10.1186/S11671-025-04225-7

Current knowledge for implementing safe and sustainable by design across the life cycle of nanosilver textiles

Author(s): Romero-Cantú, Héctor D.; Furxhi, Irini; Coelho, Carla Thais Pereira; Zanoni, Ilaria; Brigliadori, Andrea; Costa, Anna
Published in: Discover Sustainability, 2025, ISSN 2662-9984
Publisher: Spring Nature
DOI: 10.1007/S43621-025-02092-X

A novel bio-based polyurethane foam for eco-friendly and sustainable refurbishment of heritage buildings

Author(s): Fabrizio Ascione, Nicola Bianco, Rosa Francesca De Masi, Teresa Iovane, Giuseppe C. Lama, Margherita Mastellone, Gerardo Maria Mauro, Federica Recupido, Silvia Ruggiero, Alessandro Russo, Francesco Tariello, Giuseppe Peter Vanoli, Letizia Verdolotti
Published in: Energy Sources, Part A: Recovery, Utilization, and Environmental Effects, Issue 48, 2025, ISSN 1556-7036
Publisher: Informa UK Limited
DOI: 10.1080/15567036.2025.2605143

Comprehensive methodology for standardized ecotoxicological assessment of TiO2-based sunscreen leachates in aquatic environment

Author(s): Roberta Nugnes, Giulia De Negri Atanasio, Elisabetta Perata, Erica Lertora, Lorenzo Dondero, Federica Robino, Francesca Tardanico, Cristina Capelli, Fabio Ghioni, Tania Cai, Dalia Gobbato, Norina Marciani, Roberta Miroglio, Matteo Zanotti Russo, Veronica Piazza, Marco Faimali, Chiara Gambardella, Francesca Garaventa, Elena Grasselli
Published in: Frontiers in Toxicology, Issue 7, 2025, ISSN 2673-3080
Publisher: Frontiers Media SA
DOI: 10.3389/FTOX.2025.1686954

Cutting-edge development of non-isocyanate polyurethane (NIPU) foams: from sustainable precursors to environmental impact evaluation

Author(s): Federica Orabona, Federica Recupido, Giuseppe Cesare Lama, Krzysztof Polaczek, Francesco Taddeo, Tapio Salmi, Martino Di Serio, Letizia Verdolotti, Vincenzo Russo
Published in: Green Chemistry, Issue 27, 2025, ISSN 1463-9262
Publisher: Royal Society of Chemistry (RSC)
DOI: 10.1039/D4GC05796A

Quantifying relevant exposure determinants and conditions of use for welding emissions

Author(s): Antti Joonas Koivisto; Maxime Eliat; Michael Jayjock; Tareq Hussein; Alessia Nicosia
Published in: Open Research Europe, 2025, ISSN 2732-5121
Publisher: European Commission
DOI: 10.12688/OPENRESEUROPE.19498.1

Functional silver-based nanomaterials affecting zebrafish development: the adverse outcomes in relation to the nanoparticle physical and chemical structure

Author(s): Bonfanti P.; Colombo A.; Bengalli R.; Gualtieri M.; Zanoni I.; Blosi M.; Costa A.; Mantecca P.
Published in: Environmental Science: Nano, Issue Issue 6, 2024, 2024, ISSN 2051-8161
Publisher: Royal Society of Chemistry (RSC)
DOI: 10.1039/D3EN00813D

Mechanism-enabled sustainability: Dynamic retro-Diels-Alder polyurethane network for reprocessable flexible foams

Author(s): Krzysztof Polaczek, Federica Recupido, Federica Orabona, Loredana Tammaro, Giuseppe Cesare Lama, Zhanhua Wang, Giovanna Giuliana Buonocore, Letizia Verdolotti, Marino Lavorgna, Hesheng Xia
Published in: Chemical Engineering Journal, Issue 537, 2026, ISSN 1385-8947
Publisher: Elsevier BV
DOI: 10.1016/J.CEJ.2026.176175

Design of fully reprocessable composite non-isocyanate polyurethane (NIPU) foams from sustainable blends of cyclic carbonates

Author(s): Federica Orabona; Federica Recupido; Krzysztof Polaczek; Giuseppe Cesare Lama; Martina Morra; Francesco Taddeo; Martino Di Serio; Tapio Salmi; Letizia Verdolotti; Vincenzo Russo
Published in: RSC Sustainability, Issue Issue 3, 2026, 2026, ISSN 2753-8125
Publisher: RSC Sustainability
DOI: 10.1039/D5SU00946D

How credible is REACH regulation without transparency, quality criteria, assurance, and control?

Author(s): Antti Joonas Koivisto; Michael Jayjock
Published in: Open Research Europe, 2025, ISSN 2732-5121
Publisher: European Commission
DOI: 10.12688/OPENRESEUROPE.19510.1

Conference proceedings (23)

RES-22 Sister Projects Cluster Joint Poster for ANTHOS'26

Author(s): SUNRISE, INTEGRANO, INSIGHT, ANALYST
Published in: 2026
DOI: 10.5281/ZENODO.19064485

Safe and Sustainable-by-Design Approach for Functional Bio-Silica Nanomaterials: LCA and LCC Comparisons

Author(s): Filipa O. Gomes, Vinícius Cardos, Lorena Coelho, Natalia Dudchenko, Massimo Perucca, Benjamin Murray, Mattia Costamagna, Ahmad S. Aldaghi
Published in: 2025
Publisher: ANM25

Playing with Chemistry to Build a Sustainable Future

Author(s): Francesca Deganello, Maria Luisa Testa, Marco Russo, Chiara Aliotta, Chiara D’Errico, Andrea Ienco, Valentina Grasso.
Published in: 2025
Publisher: CNR DSCTM

A new approach methodology for inhalation risk assessment of new nanoparticles

Author(s): Giulia Motta, Maurizio Gualtieri, Melissa Saibene, Rossella Bengalli, Joan Cabellos, Franco Belosi, Maria Foti, Barbara Torsello, Paride Mantecca
Published in: 2024
Publisher: Nanotox2024

An Integrated Approach to Evaluate the Safety of Innovative Materials for Water Treatment According to the SSbD Framework

Author(s): Beatrice Negrini, Patrizia Bonfanti, Anita Colombo, Beatrice A. Brugger, Maurizio Gualtieri, Massimo Perucca, Paride Mantecca
Published in: 2026
Publisher: SETAC26

A sustainable methodology for implementing a practical workflow to operationalise SSbD

Author(s): Massimo Perucca, Benjamin Murray, Paride Mantecca
Published in: 2026
Publisher: SETAC26

New methodologies for the hazard assessment of advanced nanomaterials: integration of mechanistic approaches in designed case studies

Author(s): Rossella Daniela Bengalli, Maurizio Gualtieri, Stefano Cervellera, Giulia Motta, Francesca Deganello, Ilaria Zanoni, Anna Costa, Massimo Perucca, Paride Mantecca
Published in: 2025
Publisher: EUROTOX25

A NEW APPROACH METHODOLOGY TO EVALUATE THE BIOLOGICAL IMPACT OF SILVER NANOMATERIALS IN HUMAN LUNG

Author(s): Giulia Motta, Rossella Bengalli, Maurizio Gualtieri, Paride Mantecca
Published in: 2024
Publisher: 69° Conference GEI-SIBSC

IN VITRO NEW APPROACH METHODOLOGIES (NAMS) FOR THE HAZARD ASSESSMENT OF NANOMATERIALS

Author(s): R. Bengalli, G. Motta, P. Bonfanti, A. Colombo, M. Gualtieri, P. Mantecca.
Published in: 2025
Publisher: Conference GEI-SIBSC

Hazard assessment of advanced nanomaterials: the INTEGRANO testing strategy to support the Safe and sustainable by design framework

Author(s): Rossella Daniela Bengalli, Sara Marchetti, Stefano Cervellera, Beatrice Negrini, Alessandra Lama, Patrizia Bonfanti, Anita Colombo, Massimo Perucca, Maurizio Gualtieri,Paride Mantecca
Published in: 2026
Publisher: ANTHOS26

Reference and new approach methodologies in the evaluation of new (nano) materials in the safe and sustainable by design framework: the INTEGRANO project experience.

Author(s): M. Gualtieri, R.D. Bengalli, S. Cervellera, S. Marchetti, F. Deganello, P. Mantecca
Published in: 2025
Publisher: Future Material 2025

Synthesis and Characterization of Reprocessable Composite Flexible Polyurethane Foams with Self-Reorganizing Diels-Alder (DA)-Based Covalent Adaptable Networks (CANs)

Author(s): Federica Recupido, Krzysztof Polaczek, Federica Orabona, Giuseppe Cesare Lama, Marino Lavorgna, Loredana Tammaro, Qifan Zhao, Xili Lu, Hesheng Xia, Letizia Verdolotti
Published in: 2025
Publisher: International Conference on Renewable Resources & Biorefineries (RRB)

Multidimensional Integrated Quantitative Approach To Assess Safety And Sustainability Of Nanomaterials In Real Case Life Cycle Scenarios Using Nanospecific Impact Categories

Author(s): Stefano Cervellera
Published in: 2025
Publisher: Università degli Studi di Milano Bicocca

Refinement of Fish Embryo Toxicity Test To Assess Ecotoxicological Effects of Nanoparticles

Author(s): Alessandra Lama, Pamela Floris, Patrizia Bonfanti, Anita Colombo, Maurizio Gualtieri, Paride Mantecca
Publisher: SETAC26

Accelerating Safe and Sustainable by Design adoption: the role of INTEGRANO, IRISS, and PARC projects.

Author(s): Chiara Stopponi, Stefania Truffa, Doris Völker, Emma Strömberg
Publisher: ANTHOS26

INTEGRANO quantitative-based methodology to SSbD enabling R&I implementors’ acceptance

Author(s): Massimo Perucca, Benjamin Murray, Andrea Garrone, Rossella Daniela Bengalli, Maurizio Gualtieri, Paride Mantecca, Lorena Coelho, Andreia Monteiro
Published in: 2026
Publisher: ANTHO26

EMBRYOTOXIC EFFECTS OF ZnO NANOPARTICLES IN ZEBRAFISH: INFLUENCE OF THE TESTING CONDITIONS

Author(s): Alessandra Lama, Pamela Floris, Paride Mantecca, Anita Colombo, Patrizia Bonfanti
Published in: 2025
Publisher: Conference GEI-SIBSC

A LUNG CO-CULTURE MODEL TO EXPLORE THE INFLAMMATORY EFFECTS DETERMINED BY COMBINED EXPOSURE TO to PM2.5, SARS-CoV-2 AND NANO-ANTIVIRAL AGENTS

Author(s): S. Marchetti, M. Gualtieri, R. Bengalli, A. Colombo, P. Mantecca
Published in: 2025
Publisher: Conference GEI-SIBSC

Reference and new approach methodologies in the evaluation of new (nano) materials in the safe and sustainable by design framework: the INTEGRANO project experience.

Author(s): M. Gualtieri, R.D. Bengalli, S. Cervellera, S. Marchetti, F. Deganello, P. Mantecca
Published in: 2025
Publisher: Future Material 2025

Ecotoxicological Assessment of Silver Nanoparticles in the Marine Environment: A Multispecies Approach

Author(s): R. Nugnes, C. Gambardella, R. Miroglio, L. Lazzeri, F. Maccaroni, E. Costa, V. Piazza, L. Zanetti, M. Faimali, A.L. Costa, M. Blosi, I. Zanoni, M. Gualtieri, P. Mantecca, F. Garaventa
Published in: 2025
Publisher: SETAC Italian Language Branch

Integrating SSbD Principles in the Synthesis of Bio-SiO2 Functionalized with TiO2 for Sustainable Solutions

Author(s): Filipa O. Gomes, Vinícius Cardos, Lorena Coelho, Natalia Dudchenko, Massimo Perucca, Benjamin Murray
Published in: 2025
Publisher: EUROMAT25

Addressing stakeholders’ negotiation process in SSbD decision making for INTEGRANO project nano-enabled solutions

Author(s): M. Perucca, B. Murray, A. Garrone, F. O. Gomes, V. Cardoso, L. Coelho, A. Monteiro, I. Zanoni, S. Ortelli, C. Artusi, M. Serantoni, M. Blosi, A. Costa, F.Deganello, L.Boggioni, L. Verdolotti, F. Recupido, G. Lama, I. Tonani Tomasoni, V. Battistello, M. Ge
Published in: 2025
Publisher: 22nd International Conference on Nanosciences & Nanotechnologies (NN25)

Synthesis of fully bio-based and re-processable self-blowing composite Non Isocyanate Polyurethane Foams

Author(s): Federica Orabona, Krzysztof Polaczek, Federica Recupido, Giuseppe Cesare Lama,Francesco Taddeo, Tapio Salmi, Martino Di Serio, Vincenzo Russo, R. Marzella, Letizia Verdolotti
Published in: 2025
Publisher: International Conference on Renewable Resources & Biorefineries (RRB)

Other (2)

"Extended Data for ""Particle emission rates and conditions of use for the cutting of biobased composite polyurethane foam"""

Author(s): Koivisto, Antti Joonas
Published in: 2025
DOI: 10.5281/ZENODO.15727267

13th Venice Training School 2025 - teaching materials

Author(s): Alfaro Serrano, Beatriz; Hristozov, Danail; Resch, Susanne; GARCIA, AMAIA; Luhmann, Hilfegard; Friesl, Judith; Hofstätter, Norbert; Hofer, Sabine; Himly, Martin
DOI: 10.5281/ZENODO.17305647