Multidimensional Integrated Quantitative Approach To Assess Safety And Sustainability Of Nanomaterials In Real Case Life Cycle Scenarios Using Nanospecific Impact Categories

Información del proyecto

INTEGRANO

Identificador del acuerdo de subvención: 101138414

DOI

10.3030/101138414

Fecha de la firma de la CE 23 Noviembre 2023

Fecha de inicio 1 Enero 2024

Fecha de finalización 31 Diciembre 2027

Financiado con arreglo a

• Digital, Industry and Space

Coste total

€ 4 140 133,35

Aportación de la UE

€ 3 985 648,75

Coordinado por

UNIVERSITA' DEGLI STUDI DI MILANO-BICOCCA
Italy

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Websites, patent fillings, videos etc. (2)

IT platform for stakeholders engagement - SSbD Think tank
Project visual identity and website.

Documents, reports (2)

Final data management Plan
First data management Plan

Data management Plan

Publicaciones

Peer reviewed articles (10)

Comparative toxicity and environmental impact assessments of sonochemically-synthesized CuO and Zn-doped CuO nanoparticles using zebrafish and LCA tools

Autores: Beatrice Negrini; Pamela Floris; Christian D’Abramo; Seyed Ahmad Aldaghi; Mattia Costamagna; Massimo Perucca; Melissa Saibene; Ilana Perelshtein; Anita Colombo; Patrizia Bonfanti; Paride Mantecca
Publicado en: Discover Nano, Edición Volume 20, article number 51, 2025, ISSN 2731-9229
Editor: Discover Nano
DOI: 10.1186/S11671-025-04225-7

Current knowledge for implementing safe and sustainable by design across the life cycle of nanosilver textiles

Autores: Romero-Cantú, Héctor D.; Furxhi, Irini; Coelho, Carla Thais Pereira; Zanoni, Ilaria; Brigliadori, Andrea; Costa, Anna
Publicado en: Discover Sustainability, 2025, ISSN 2662-9984
Editor: Spring Nature
DOI: 10.1007/S43621-025-02092-X

A novel bio-based polyurethane foam for eco-friendly and sustainable refurbishment of heritage buildings

Autores: Fabrizio Ascione, Nicola Bianco, Rosa Francesca De Masi, Teresa Iovane, Giuseppe C. Lama, Margherita Mastellone, Gerardo Maria Mauro, Federica Recupido, Silvia Ruggiero, Alessandro Russo, Francesco Tariello, Giuseppe Peter Vanoli, Letizia Verdolotti
Publicado en: Energy Sources, Part A: Recovery, Utilization, and Environmental Effects, Edición 48, 2025, ISSN 1556-7036
Editor: Informa UK Limited
DOI: 10.1080/15567036.2025.2605143

Comprehensive methodology for standardized ecotoxicological assessment of TiO2-based sunscreen leachates in aquatic environment

Autores: Roberta Nugnes, Giulia De Negri Atanasio, Elisabetta Perata, Erica Lertora, Lorenzo Dondero, Federica Robino, Francesca Tardanico, Cristina Capelli, Fabio Ghioni, Tania Cai, Dalia Gobbato, Norina Marciani, Roberta Miroglio, Matteo Zanotti Russo, Veronica Piazza, Marco Faimali, Chiara Gambardella, Francesca Garaventa, Elena Grasselli
Publicado en: Frontiers in Toxicology, Edición 7, 2025, ISSN 2673-3080
Editor: Frontiers Media SA
DOI: 10.3389/FTOX.2025.1686954

Cutting-edge development of non-isocyanate polyurethane (NIPU) foams: from sustainable precursors to environmental impact evaluation

Autores: Federica Orabona, Federica Recupido, Giuseppe Cesare Lama, Krzysztof Polaczek, Francesco Taddeo, Tapio Salmi, Martino Di Serio, Letizia Verdolotti, Vincenzo Russo
Publicado en: Green Chemistry, Edición 27, 2025, ISSN 1463-9262
Editor: Royal Society of Chemistry (RSC)
DOI: 10.1039/D4GC05796A

Quantifying relevant exposure determinants and conditions of use for welding emissions

Autores: Antti Joonas Koivisto; Maxime Eliat; Michael Jayjock; Tareq Hussein; Alessia Nicosia
Publicado en: Open Research Europe, 2025, ISSN 2732-5121
Editor: European Commission
DOI: 10.12688/OPENRESEUROPE.19498.1

Functional silver-based nanomaterials affecting zebrafish development: the adverse outcomes in relation to the nanoparticle physical and chemical structure

Autores: Bonfanti P.; Colombo A.; Bengalli R.; Gualtieri M.; Zanoni I.; Blosi M.; Costa A.; Mantecca P.
Publicado en: Environmental Science: Nano, Edición Edición 6, 2024, 2024, ISSN 2051-8161
Editor: Royal Society of Chemistry (RSC)
DOI: 10.1039/D3EN00813D

Mechanism-enabled sustainability: Dynamic retro-Diels-Alder polyurethane network for reprocessable flexible foams

Autores: Krzysztof Polaczek, Federica Recupido, Federica Orabona, Loredana Tammaro, Giuseppe Cesare Lama, Zhanhua Wang, Giovanna Giuliana Buonocore, Letizia Verdolotti, Marino Lavorgna, Hesheng Xia
Publicado en: Chemical Engineering Journal, Edición 537, 2026, ISSN 1385-8947
Editor: Elsevier BV
DOI: 10.1016/J.CEJ.2026.176175

Design of fully reprocessable composite non-isocyanate polyurethane (NIPU) foams from sustainable blends of cyclic carbonates

Autores: Federica Orabona; Federica Recupido; Krzysztof Polaczek; Giuseppe Cesare Lama; Martina Morra; Francesco Taddeo; Martino Di Serio; Tapio Salmi; Letizia Verdolotti; Vincenzo Russo
Publicado en: RSC Sustainability, Edición Edición 3, 2026, 2026, ISSN 2753-8125
Editor: RSC Sustainability
DOI: 10.1039/D5SU00946D

How credible is REACH regulation without transparency, quality criteria, assurance, and control?

Autores: Antti Joonas Koivisto; Michael Jayjock
Publicado en: Open Research Europe, 2025, ISSN 2732-5121
Editor: European Commission
DOI: 10.12688/OPENRESEUROPE.19510.1

Conference proceedings (23)

RES-22 Sister Projects Cluster Joint Poster for ANTHOS'26

Autores: SUNRISE, INTEGRANO, INSIGHT, ANALYST
Publicado en: 2026
DOI: 10.5281/ZENODO.19064485

Safe and Sustainable-by-Design Approach for Functional Bio-Silica Nanomaterials: LCA and LCC Comparisons

Autores: Filipa O. Gomes, Vinícius Cardos, Lorena Coelho, Natalia Dudchenko, Massimo Perucca, Benjamin Murray, Mattia Costamagna, Ahmad S. Aldaghi
Publicado en: 2025
Editor: ANM25

Playing with Chemistry to Build a Sustainable Future

Autores: Francesca Deganello, Maria Luisa Testa, Marco Russo, Chiara Aliotta, Chiara D’Errico, Andrea Ienco, Valentina Grasso.
Publicado en: 2025
Editor: CNR DSCTM

A new approach methodology for inhalation risk assessment of new nanoparticles

Autores: Giulia Motta, Maurizio Gualtieri, Melissa Saibene, Rossella Bengalli, Joan Cabellos, Franco Belosi, Maria Foti, Barbara Torsello, Paride Mantecca
Publicado en: 2024
Editor: Nanotox2024

An Integrated Approach to Evaluate the Safety of Innovative Materials for Water Treatment According to the SSbD Framework

Autores: Beatrice Negrini, Patrizia Bonfanti, Anita Colombo, Beatrice A. Brugger, Maurizio Gualtieri, Massimo Perucca, Paride Mantecca
Publicado en: 2026
Editor: SETAC26

A sustainable methodology for implementing a practical workflow to operationalise SSbD

Autores: Massimo Perucca, Benjamin Murray, Paride Mantecca
Publicado en: 2026
Editor: SETAC26

New methodologies for the hazard assessment of advanced nanomaterials: integration of mechanistic approaches in designed case studies

Autores: Rossella Daniela Bengalli, Maurizio Gualtieri, Stefano Cervellera, Giulia Motta, Francesca Deganello, Ilaria Zanoni, Anna Costa, Massimo Perucca, Paride Mantecca
Publicado en: 2025
Editor: EUROTOX25

A NEW APPROACH METHODOLOGY TO EVALUATE THE BIOLOGICAL IMPACT OF SILVER NANOMATERIALS IN HUMAN LUNG

Autores: Giulia Motta, Rossella Bengalli, Maurizio Gualtieri, Paride Mantecca
Publicado en: 2024
Editor: 69° Conference GEI-SIBSC

IN VITRO NEW APPROACH METHODOLOGIES (NAMS) FOR THE HAZARD ASSESSMENT OF NANOMATERIALS

Autores: R. Bengalli, G. Motta, P. Bonfanti, A. Colombo, M. Gualtieri, P. Mantecca.
Publicado en: 2025
Editor: Conference GEI-SIBSC

Hazard assessment of advanced nanomaterials: the INTEGRANO testing strategy to support the Safe and sustainable by design framework

Autores: Rossella Daniela Bengalli, Sara Marchetti, Stefano Cervellera, Beatrice Negrini, Alessandra Lama, Patrizia Bonfanti, Anita Colombo, Massimo Perucca, Maurizio Gualtieri,Paride Mantecca
Publicado en: 2026
Editor: ANTHOS26

Reference and new approach methodologies in the evaluation of new (nano) materials in the safe and sustainable by design framework: the INTEGRANO project experience.

Autores: M. Gualtieri, R.D. Bengalli, S. Cervellera, S. Marchetti, F. Deganello, P. Mantecca
Publicado en: 2025
Editor: Future Material 2025

Synthesis and Characterization of Reprocessable Composite Flexible Polyurethane Foams with Self-Reorganizing Diels-Alder (DA)-Based Covalent Adaptable Networks (CANs)

Autores: Federica Recupido, Krzysztof Polaczek, Federica Orabona, Giuseppe Cesare Lama, Marino Lavorgna, Loredana Tammaro, Qifan Zhao, Xili Lu, Hesheng Xia, Letizia Verdolotti
Publicado en: 2025
Editor: International Conference on Renewable Resources & Biorefineries (RRB)

Multidimensional Integrated Quantitative Approach To Assess Safety And Sustainability Of Nanomaterials In Real Case Life Cycle Scenarios Using Nanospecific Impact Categories

Autores: Stefano Cervellera
Publicado en: 2025
Editor: Università degli Studi di Milano Bicocca

Refinement of Fish Embryo Toxicity Test To Assess Ecotoxicological Effects of Nanoparticles

Autores: Alessandra Lama, Pamela Floris, Patrizia Bonfanti, Anita Colombo, Maurizio Gualtieri, Paride Mantecca
Editor: SETAC26

Accelerating Safe and Sustainable by Design adoption: the role of INTEGRANO, IRISS, and PARC projects.

Autores: Chiara Stopponi, Stefania Truffa, Doris Völker, Emma Strömberg
Editor: ANTHOS26

INTEGRANO quantitative-based methodology to SSbD enabling R&I implementors’ acceptance

Autores: Massimo Perucca, Benjamin Murray, Andrea Garrone, Rossella Daniela Bengalli, Maurizio Gualtieri, Paride Mantecca, Lorena Coelho, Andreia Monteiro
Publicado en: 2026
Editor: ANTHO26

EMBRYOTOXIC EFFECTS OF ZnO NANOPARTICLES IN ZEBRAFISH: INFLUENCE OF THE TESTING CONDITIONS

Autores: Alessandra Lama, Pamela Floris, Paride Mantecca, Anita Colombo, Patrizia Bonfanti
Publicado en: 2025
Editor: Conference GEI-SIBSC

A LUNG CO-CULTURE MODEL TO EXPLORE THE INFLAMMATORY EFFECTS DETERMINED BY COMBINED EXPOSURE TO to PM2.5, SARS-CoV-2 AND NANO-ANTIVIRAL AGENTS

Autores: S. Marchetti, M. Gualtieri, R. Bengalli, A. Colombo, P. Mantecca
Publicado en: 2025
Editor: Conference GEI-SIBSC

Reference and new approach methodologies in the evaluation of new (nano) materials in the safe and sustainable by design framework: the INTEGRANO project experience.

Autores: M. Gualtieri, R.D. Bengalli, S. Cervellera, S. Marchetti, F. Deganello, P. Mantecca
Publicado en: 2025
Editor: Future Material 2025

Ecotoxicological Assessment of Silver Nanoparticles in the Marine Environment: A Multispecies Approach

Autores: R. Nugnes, C. Gambardella, R. Miroglio, L. Lazzeri, F. Maccaroni, E. Costa, V. Piazza, L. Zanetti, M. Faimali, A.L. Costa, M. Blosi, I. Zanoni, M. Gualtieri, P. Mantecca, F. Garaventa
Publicado en: 2025
Editor: SETAC Italian Language Branch

Integrating SSbD Principles in the Synthesis of Bio-SiO2 Functionalized with TiO2 for Sustainable Solutions

Autores: Filipa O. Gomes, Vinícius Cardos, Lorena Coelho, Natalia Dudchenko, Massimo Perucca, Benjamin Murray
Publicado en: 2025
Editor: EUROMAT25

Addressing stakeholders’ negotiation process in SSbD decision making for INTEGRANO project nano-enabled solutions

Autores: M. Perucca, B. Murray, A. Garrone, F. O. Gomes, V. Cardoso, L. Coelho, A. Monteiro, I. Zanoni, S. Ortelli, C. Artusi, M. Serantoni, M. Blosi, A. Costa, F.Deganello, L.Boggioni, L. Verdolotti, F. Recupido, G. Lama, I. Tonani Tomasoni, V. Battistello, M. Ge
Publicado en: 2025
Editor: 22nd International Conference on Nanosciences & Nanotechnologies (NN25)

Synthesis of fully bio-based and re-processable self-blowing composite Non Isocyanate Polyurethane Foams

Autores: Federica Orabona, Krzysztof Polaczek, Federica Recupido, Giuseppe Cesare Lama,Francesco Taddeo, Tapio Salmi, Martino Di Serio, Vincenzo Russo, R. Marzella, Letizia Verdolotti
Publicado en: 2025
Editor: International Conference on Renewable Resources & Biorefineries (RRB)

Other (2)

"Extended Data for ""Particle emission rates and conditions of use for the cutting of biobased composite polyurethane foam"""

Autores: Koivisto, Antti Joonas
Publicado en: 2025
DOI: 10.5281/ZENODO.15727267

13th Venice Training School 2025 - teaching materials

Autores: Alfaro Serrano, Beatriz; Hristozov, Danail; Resch, Susanne; GARCIA, AMAIA; Luhmann, Hilfegard; Friesl, Judith; Hofstätter, Norbert; Hofer, Sabine; Himly, Martin
DOI: 10.5281/ZENODO.17305647