Brain fluids - Transport and clearance

Información del proyecto

aCleanBrain

Identificador del acuerdo de subvención: 101141807

DOI

10.3030/101141807

Fecha de la firma de la CE 12 Julio 2024

Fecha de inicio 1 Agosto 2024

Fecha de finalización 31 Julio 2029

Financiado con arreglo a

• European Research Council (ERC)

Coste total

€ 2 493 750,00

Aportación de la UE

€ 2 493 750,00

Coordinado por

SIMULA RESEARCH LABORATORY AS
Norway

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Data Management Plan (1)

Data Management Plan

Publicaciones

Peer reviewed articles (12)

Multiphasic transport in the human cranial dura: how meningeal lymphatic vessels drive waste clearance from brain cerebrospinal fluid

Autores: Alberto Girelli, Andreas Solheim, Sofie Lysholm Lian, Tryggve Holck Storås, Kaja Nordengen, Kent-Andre Mardal
Publicado en: Fluids and Barriers of the CNS, 2026, ISSN 2045-8118
Editor: Springer Science and Business Media LLC
DOI: 10.1186/S12987-026-00861-Y

The impact of human brain geometry on the transport of an intrathecal tracer

Autores: Andreas Solheim, Geir Ringstad, Per Kristian Eide, Lars Magnus Valnes, Kent-Andre Mardal
Publicado en: Fluids and Barriers of the CNS, Edición 23, 2026, ISSN 2045-8118
Editor: Springer Science and Business Media LLC
DOI: 10.1186/S12987-026-00764-Y

Stretch and flow at the gliovascular interface: High-fidelity modeling of astrocyte endfeet

Autores: Marius Causemann, Rune Enger, Marie E. Rognes
Publicado en: Proceedings of the National Academy of Sciences, Edición 123, 2026, ISSN 0027-8424
Editor: National Academy of Sciences
DOI: 10.1073/PNAS.2517059123

Modeling glioma-induced impairments on the glymphatic system

Autores: Alexandre Poulain, Jørgen Riseth, Kyrre E. Emblem, Kent-Andre Mardal
Publicado en: Fluids and Barriers of the CNS, Edición 23, 2026, ISSN 2045-8118
Editor: Springer Science and Business Media LLC
DOI: 10.1186/S12987-025-00736-8

<scp>T2</scp> ‐Weighted <scp>T1</scp> Mapping and Automated Segmentation of <scp>CSF</scp> : Assessment of Solute Gradients in the Healthy Brain

Autores: Tryggve Holck Storås, Sofie Lysholm Lian, Ingrid Mossige, Jørgen Riseth, Siri Fløgstad Svensson, Grethe Løvland, Geir Ringstad, Kent‐André Mardal, Kyrre Eeg Emblem, Kaja Nordengen
Publicado en: Journal of Magnetic Resonance Imaging, Edición 64, 2026, ISSN 1053-1807
Editor: Wiley
DOI: 10.1002/JMRI.70169

On the prospects of interpolatory spline bases for accurate mass lumping strategies in isogeometric analysis

Autores: Yannis Voet, Espen Sande
Publicado en: Computer Methods in Applied Mechanics and Engineering, Edición 452, 2026, ISSN 0045-7825
Editor: Elsevier BV
DOI: 10.1016/J.CMA.2026.118762

Parameter-Robust Preconditioner for Stokes-Darcy Coupled Problem with Lagrange Multiplier

Autores: Xiaozhe Hu, Miroslav Kuchta, Kent-Andre Mardal, Xue Wang
Publicado en: SIAM Journal on Scientific Computing, Edición 48, 2026, ISSN 1064-8275
Editor: Society for Industrial & Applied Mathematics (SIAM)
DOI: 10.1137/25M1744393

Parameter-Robust Preconditioners for a Four-Field Thermo-Poroelasticity Model

Autores: Mingchao Cai, Miroslav Kuchta, Jingzhi Li, Ziliang Li, Kent-Andre Mardal
Publicado en: SIAM Journal on Scientific Computing, Edición 48, 2026, ISSN 1064-8275
Editor: Society for Industrial & Applied Mathematics (SIAM)
DOI: 10.1137/25M1726923

Parameter-Robust Preconditioners for a Cell-by-Cell Poroelasticity Model with Interface Coupling

Autores: Marius Causemann, Miroslav Kuchta
Publicado en: SIAM Journal on Scientific Computing, Edición 48, 2026, ISSN 1064-8275
Editor: Society for Industrial & Applied Mathematics (SIAM)
DOI: 10.1137/25M1770151

Estimation of fluid flow velocities in cortical brain tissue driven by the microvasculature

Autores: Timo Koch, Kent-André Mardal
Publicado en: Interface Focus, Edición 15, 2025, ISSN 2042-8901
Editor: The Royal Society
DOI: 10.1098/RSFS.2024.0042

In-silico solute transport via perivascular networks in the human intracranial space

Autores: Marius Causemann, Miroslav Kuchta, Rami Masri, Marie E. Rognes
Publicado en: Nature Communications, 2026, ISSN 2041-1723
Editor: Springer Science and Business Media LLC
DOI: 10.1038/S41467-026-77174-Z

A cut finite element method for the Biot system of poroelasticity

Autores: Nanna Berre, Kent-Andre Mardal, André Massing, Ivan Yotov
Publicado en: Computer Methods in Applied Mechanics and Engineering, Edición 458, 2026, ISSN 0045-7825
Editor: Elsevier BV
DOI: 10.1016/J.CMA.2026.119048

Book chapters (6)

Computing for Life: Modeling and Simulation of Electrodiffusion in Dense Reconstructions of Cerebral Tissue

Autores: Halvor Herlyng, Marius Causemann, Gaute T. Einevoll, Ada J. Ellingsrud, Geir Halnes, Marie E. Rognes
Publicado en: Lecture Notes in Computational Science and Engineering, Numerical Analysis and Scientific Computing: an Anthology, 2026
Editor: Springer Nature Switzerland
DOI: 10.1007/978-3-032-33428-2_14

Quantifying cerebrospinal fluid tracer concentration in the brain

Autores: Bastian Zapf, Lars Magnus Valnes, Kent-Andre Mardal, & Ludmil Zikatanov
Editor: Springer

Estimating molecular transport parameters using inverse PDE models

Autores: Bastian Zapf, Marius Zeinhofer, Kent-Andre Mardal
Publicado en: Simula SpringerBriefs on Computing, Mathematical Modelling of the Human Brain II, 2025
Editor: Springer Nature Switzerland
DOI: 10.1007/978-3-032-00679-0_7

Meshing the intracranial compartments: The cerebellum, cerebrum, brainstem, and cerebrospinal fluid

Autores: Lars Magnus Valnes, & Kent-Andre Mardal
Publicado en: Meshing the intracranial compartments: The cerebellum, cerebrum, brainstem, and cerebrospinal fluid
Editor: Springer Cham
DOI: 10.1007/978-3-0

Two-compartment modeling of tracer transport in the brain

Autores: Jørgen N. Riseth, Timo Koch, Kent-Andre Mardal
Publicado en: Simula SpringerBriefs on Computing, Mathematical Modelling of the Human Brain II, 2025
Editor: Springer Nature Switzerland
DOI: 10.1007/978-3-032-00679-0_8

Signal increase ratio prediction with CNNs

Autores: Marius Zeinhofer, Kent-Andre Mardal
Publicado en: Simula SpringerBriefs on Computing, Mathematical Modelling of the Human Brain II, 2025
Editor: Springer Nature Switzerland
DOI: 10.1007/978-3-032-00679-0_6