Brain fluids - Transport and clearance

Informazioni relative al progetto

aCleanBrain

ID dell’accordo di sovvenzione: 101141807

DOI

10.3030/101141807

Data della firma CE 12 Luglio 2024

Data di avvio 1 Agosto 2024

Data di completamento 31 Luglio 2029

Finanziato da

• European Research Council (ERC)

Costo totale

€ 2 493 750,00

Contributo UE

€ 2 493 750,00

Coordinato da

SIMULA RESEARCH LABORATORY AS
Norway

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Data Management Plan (1)

Data Management Plan

Pubblicazioni

Peer reviewed articles (12)

Multiphasic transport in the human cranial dura: how meningeal lymphatic vessels drive waste clearance from brain cerebrospinal fluid

Autori: Alberto Girelli, Andreas Solheim, Sofie Lysholm Lian, Tryggve Holck Storås, Kaja Nordengen, Kent-Andre Mardal
Pubblicato in: Fluids and Barriers of the CNS, 2026, ISSN 2045-8118
Editore: Springer Science and Business Media LLC
DOI: 10.1186/S12987-026-00861-Y

The impact of human brain geometry on the transport of an intrathecal tracer

Autori: Andreas Solheim, Geir Ringstad, Per Kristian Eide, Lars Magnus Valnes, Kent-Andre Mardal
Pubblicato in: Fluids and Barriers of the CNS, Numero 23, 2026, ISSN 2045-8118
Editore: Springer Science and Business Media LLC
DOI: 10.1186/S12987-026-00764-Y

Stretch and flow at the gliovascular interface: High-fidelity modeling of astrocyte endfeet

Autori: Marius Causemann, Rune Enger, Marie E. Rognes
Pubblicato in: Proceedings of the National Academy of Sciences, Numero 123, 2026, ISSN 0027-8424
Editore: National Academy of Sciences
DOI: 10.1073/PNAS.2517059123

Modeling glioma-induced impairments on the glymphatic system

Autori: Alexandre Poulain, Jørgen Riseth, Kyrre E. Emblem, Kent-Andre Mardal
Pubblicato in: Fluids and Barriers of the CNS, Numero 23, 2026, ISSN 2045-8118
Editore: Springer Science and Business Media LLC
DOI: 10.1186/S12987-025-00736-8

<scp>T2</scp> ‐Weighted <scp>T1</scp> Mapping and Automated Segmentation of <scp>CSF</scp> : Assessment of Solute Gradients in the Healthy Brain

Autori: Tryggve Holck Storås, Sofie Lysholm Lian, Ingrid Mossige, Jørgen Riseth, Siri Fløgstad Svensson, Grethe Løvland, Geir Ringstad, Kent‐André Mardal, Kyrre Eeg Emblem, Kaja Nordengen
Pubblicato in: Journal of Magnetic Resonance Imaging, Numero 64, 2026, ISSN 1053-1807
Editore: Wiley
DOI: 10.1002/JMRI.70169

On the prospects of interpolatory spline bases for accurate mass lumping strategies in isogeometric analysis

Autori: Yannis Voet, Espen Sande
Pubblicato in: Computer Methods in Applied Mechanics and Engineering, Numero 452, 2026, ISSN 0045-7825
Editore: Elsevier BV
DOI: 10.1016/J.CMA.2026.118762

Parameter-Robust Preconditioner for Stokes-Darcy Coupled Problem with Lagrange Multiplier

Autori: Xiaozhe Hu, Miroslav Kuchta, Kent-Andre Mardal, Xue Wang
Pubblicato in: SIAM Journal on Scientific Computing, Numero 48, 2026, ISSN 1064-8275
Editore: Society for Industrial & Applied Mathematics (SIAM)
DOI: 10.1137/25M1744393

Parameter-Robust Preconditioners for a Four-Field Thermo-Poroelasticity Model

Autori: Mingchao Cai, Miroslav Kuchta, Jingzhi Li, Ziliang Li, Kent-Andre Mardal
Pubblicato in: SIAM Journal on Scientific Computing, Numero 48, 2026, ISSN 1064-8275
Editore: Society for Industrial & Applied Mathematics (SIAM)
DOI: 10.1137/25M1726923

Parameter-Robust Preconditioners for a Cell-by-Cell Poroelasticity Model with Interface Coupling

Autori: Marius Causemann, Miroslav Kuchta
Pubblicato in: SIAM Journal on Scientific Computing, Numero 48, 2026, ISSN 1064-8275
Editore: Society for Industrial & Applied Mathematics (SIAM)
DOI: 10.1137/25M1770151

Estimation of fluid flow velocities in cortical brain tissue driven by the microvasculature

Autori: Timo Koch, Kent-André Mardal
Pubblicato in: Interface Focus, Numero 15, 2025, ISSN 2042-8901
Editore: The Royal Society
DOI: 10.1098/RSFS.2024.0042

In-silico solute transport via perivascular networks in the human intracranial space

Autori: Marius Causemann, Miroslav Kuchta, Rami Masri, Marie E. Rognes
Pubblicato in: Nature Communications, 2026, ISSN 2041-1723
Editore: Springer Science and Business Media LLC
DOI: 10.1038/S41467-026-77174-Z

A cut finite element method for the Biot system of poroelasticity

Autori: Nanna Berre, Kent-Andre Mardal, André Massing, Ivan Yotov
Pubblicato in: Computer Methods in Applied Mechanics and Engineering, Numero 458, 2026, ISSN 0045-7825
Editore: Elsevier BV
DOI: 10.1016/J.CMA.2026.119048

Book chapters (6)

Computing for Life: Modeling and Simulation of Electrodiffusion in Dense Reconstructions of Cerebral Tissue

Autori: Halvor Herlyng, Marius Causemann, Gaute T. Einevoll, Ada J. Ellingsrud, Geir Halnes, Marie E. Rognes
Pubblicato in: Lecture Notes in Computational Science and Engineering, Numerical Analysis and Scientific Computing: an Anthology, 2026
Editore: Springer Nature Switzerland
DOI: 10.1007/978-3-032-33428-2_14

Quantifying cerebrospinal fluid tracer concentration in the brain

Autori: Bastian Zapf, Lars Magnus Valnes, Kent-Andre Mardal, & Ludmil Zikatanov
Editore: Springer

Estimating molecular transport parameters using inverse PDE models

Autori: Bastian Zapf, Marius Zeinhofer, Kent-Andre Mardal
Pubblicato in: Simula SpringerBriefs on Computing, Mathematical Modelling of the Human Brain II, 2025
Editore: Springer Nature Switzerland
DOI: 10.1007/978-3-032-00679-0_7

Meshing the intracranial compartments: The cerebellum, cerebrum, brainstem, and cerebrospinal fluid

Autori: Lars Magnus Valnes, & Kent-Andre Mardal
Pubblicato in: Meshing the intracranial compartments: The cerebellum, cerebrum, brainstem, and cerebrospinal fluid
Editore: Springer Cham
DOI: 10.1007/978-3-0

Two-compartment modeling of tracer transport in the brain

Autori: Jørgen N. Riseth, Timo Koch, Kent-Andre Mardal
Pubblicato in: Simula SpringerBriefs on Computing, Mathematical Modelling of the Human Brain II, 2025
Editore: Springer Nature Switzerland
DOI: 10.1007/978-3-032-00679-0_8

Signal increase ratio prediction with CNNs

Autori: Marius Zeinhofer, Kent-Andre Mardal
Pubblicato in: Simula SpringerBriefs on Computing, Mathematical Modelling of the Human Brain II, 2025
Editore: Springer Nature Switzerland
DOI: 10.1007/978-3-032-00679-0_6