Fortifying the automated smartphone-based Cough Audio classification for rapid triaGE testing for tuberculosis project

Project Information

4-CAGE-TB

Grant agreement ID: 101145817

DOI

10.3030/101145817

EC signature date 6 March 2024

Start date 1 January 2025

End date 31 December 2026

Funded under

• Health

Total cost

€ 981 469,25

EU contribution

€ 981 469,25

Coordinated by

STELLENBOSCH UNIVERSITY
South Africa

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Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Documents, reports (22)

(Interim) capacity development report

This deliverable was successfully fulfilled in the parent project, CAGE-TB. Nevertheless, we are open to making amendments if deemed necessary in accordance with the terms of this agreement.

Consortium agreement for 4-CAGE-TB

This agreement will be established prior to the commencement of 4-CAGE-TB.

Data analysis plan

The deliverable was successfully completed within the parent project, CAGE-TB. However, we remain open to making amendments if deemed necessary in alignment with the terms of this agreement. Additionally, it is worth noting that this work package will be concluded before the commencement of 4-CAGE-TB.

Communication, dissemination, and exploitation (CDE) plan

This deliverable was successfully fulfilled in the parent project, CAGE-TB. Nevertheless, we are open to making amendments if deemed necessary in accordance with the terms of this agreement.

(Interim) analysis report (implementation research and human centred design)

Report

Standard Operating Procedures

Documents to ensure consistently high-quality work. This deliverable was successfully fulfilled in the parent project, CAGE-TB. Nevertheless, we are open to making amendments if deemed necessary in accordance with the terms of this agreement.

Investigator's brochure

Document describing intervention. The deliverable was successfully completed within the parent project, CAGE-TB. However, we remain open to making amendments if deemed necessary in alignment with the terms of this agreement. Additionally, it is worth noting that this work package will be concluded before the commencement of 4-CAGE-TB.

Monitoring visit plan and quality assurance

Document plan. The deliverable was successfully completed within the parent project, CAGE-TB. However, we remain open to making amendments if deemed necessary in alignment with the terms of this agreement. Additionally, it is worth noting that this work package will be concluded before the commencement of 4-CAGE-TB.

Midterm recruitment report (discovery cohort)

The deliverable was successfully completed within the parent project, CAGE-TB. However, we remain open to making amendments if deemed necessary in alignment with the terms of this agreement. Additionally, it is worth noting that this work package will be concluded before the commencement of 4-CAGE-TB.

Community engagement plan

This deliverable was successfully fulfilled in the parent project, CAGE-TB. Nevertheless, we are open to making amendments if deemed necessary in accordance with the terms of this agreement.

Data transfer agreement

Document. This deliverable was successfully fulfilled in the parent project, CAGE-TB. Nevertheless, we are open to making amendments if deemed necessary in accordance with the terms of this agreement.

All approvals package

The deliverable was successfully completed within the parent project, CAGE-TB. However, we remain open to making amendments if deemed necessary in alignment with the terms of this agreement.

Data management plan (applies to both the discovery and validation cohorts)

Document. This deliverable was successfully fulfilled in the parent project, CAGE-TB. Nevertheless, we are open to making amendments if deemed necessary in accordance with the terms of this agreement.

Procedure for immediate reporting to EDCTP

Document for breaches of data integrity, data protection and privacy, scientific misconduct and ethics. This deliverable was successfully fulfilled in the parent project, CAGE-TB. Nevertheless, we are open to making amendments if deemed necessary in accordance with the terms of this agreement.

Consortium meeting Year 1

Meeting minutes.

Clinical progress plan with projected dates

The deliverable was successfully completed within the parent project, CAGE-TB. However, we remain open to making amendments if deemed necessary in alignment with the terms of this agreement. Additionally, it is worth noting that this work package will be concluded before the commencement of 4-CAGE-TB.

Incidental findings policy

Document describing policy. The deliverable was successfully completed within the parent project, CAGE-TB. However, we remain open to making amendments if deemed necessary in alignment with the terms of this agreement. Additionally, it is worth noting that this work package will be concluded before the commencement of 4-CAGE-TB.

Monitoring visits (including start and close-outs)

Monitoring visit report.

Project plan and Gantt chart with critical path

Gantt chart illustrating critical path. This deliverable was successfully fulfilled in the parent project, CAGE-TB. Nevertheless, the Gantt chart was amended for this project and will be submitted.

Declarations on compliance with national/ EU data legislation

Signed declaration from institutions transferring data. The deliverable was successfully completed within the parent project, CAGE-TB. However, we remain open to making amendments if deemed necessary in alignment with the terms of this agreement. Additionally, it is worth noting that this work package will be concluded before the commencement of 4-CAGE-TB.

Monitoring & Evaluation log and framework

Document. This deliverable was successfully fulfilled in the parent project, CAGE-TB. Nevertheless, we are open to making amendments if deemed necessary in accordance with the terms of this agreement.

Clinical trials insurance

Insurance certificate. The deliverable was successfully completed within the parent project, CAGE-TB. However, we remain open to making amendments if deemed necessary in alignment with the terms of this agreement. Additionally, it is worth noting that this work package will be concluded before the commencement of 4-CAGE-TB.

Websites, patent fillings, videos etc. (2)

Registration of clinical study

Link to registration. The deliverable was successfully completed within the parent project, CAGE-TB. However, we remain open to making amendments if deemed necessary in alignment with the terms of this agreement. Additionally, it is worth noting that this work package will be concluded before the commencement of 4-CAGE-TB.

Website

Link to website. This deliverable was successfully fulfilled in the parent project, CAGE-TB. Nevertheless, we are open to making amendments if deemed necessary in accordance with the terms of this agreement.

Publications

Peer reviewed articles (7)

Diagnostic Accuracy of LiquidArray MTB-XDR VER 1.0 for the Detection of <i>Mycobacterium tuberculosis</i> Complex, Fluoroquinolone, Amikacin, Ethambutol, and Linezolid Susceptibility

Author(s): Erick Auma, Rencia Alberts, Brigitta Derendinger, Rouxjeane Venter, Elizabeth M Streicher, Samantha Pillay, Yonas T Ghebrekristos, Moses Mburu, Morten Ruhwald, Robin Warren, Adam Penn-Nicholson, Grant Theron, Margaretha de Vos
Published in: Clinical Infectious Diseases, Issue 81, 2025, ISSN 1058-4838
Publisher: Oxford University Press (OUP)
DOI: 10.1093/CID/CIAE614

Blood RNA biomarkers and C-reactive protein for triage of adult patients with tuberculosis lymphadenitis and pericarditis in South Africa: a single-centre, prospective, observational, diagnostic accuracy study

Author(s): Tiffeney Mann, Stephanie Minnies, Rishi K Gupta, Byron W P Reeve, Georgina Nyawo, Zaida Palmer, Charissa Naidoo, Anton Doubell, Alfonso Pecoraro, Thadathilankal-Jess John, Pawel Schubert, Claire J Calderwood, Aneesh Chandran, Grant Theron, Mahdad Noursadeghi
Published in: The Lancet Microbe, Issue 6, 2025, ISSN 2666-5247
Publisher: Elsevier BV
DOI: 10.1016/J.LANMIC.2025.101153

Diagnostic accuracy of Truenat MTB Ultima on sputum for pulmonary tuberculosis diagnosis in an HIV-endemic setting

Author(s): Shima M. Abdulgader, Arthur M. Chiwaya, Welile V. Nwamba, Byron W.P. Reeve, Zaida Palmer, Hridesh Mishra, Desiree Mbu, Nondumiso Lushozi, Zola Nkwanyana, Morten Ruhwald, Adam Penn-Nicholson, Robin Warren, Grant Theron
Published in: Clinical Microbiology and Infection, Issue 31, 2025, ISSN 1198-743X
Publisher: Elsevier BV
DOI: 10.1016/J.CMI.2025.04.013

Xpert MTB/RIF Ultra-resistant and MTBDR <i>plus-</i> susceptible rifampicin results in people with tuberculosis: utility of FluoroType MTBDR and deep sequencing

Author(s): Yonas Ghebrekristos, Aysha Ahmed, Natalie Beylis, Sarishna Singh, Christoffel Opperman, Fahd Naufal, Megan Folkerts, David Engelthaler, Erick Auma, Rouxjeane Venter, Ghowa Booley, John Metcalfe, Robin Warren, Grant Theron
Published in: Antimicrobial Agents and Chemotherapy, Issue 69, 2025, ISSN 0066-4804
Publisher: American Society for Microbiology
DOI: 10.1128/AAC.01671-24

Detection of Aerosolized <i>Mycobacterium tuberculosis</i> DNA From Adults Being Investigated for Pulmonary Tuberculosis via an Electrostatic Sampler in a South African Primary Care Setting

Author(s): Jay Achar, Rouxjeane Venter, Jamie van Schalkwyk, Zandile Booi, Zama Mahlobo, Zaida Palmer, Nuno Rufino de Sousa, Knut Lönnroth, James A Seddon, Antonio Gigliotti Rothfuchs, Grant Theron
Published in: Open Forum Infectious Diseases, Issue 12, 2025, ISSN 2328-8957
Publisher: Oxford University Press (OUP)
DOI: 10.1093/OFID/OFAF593

Diagnostic accuracy of point-of-care triage tests for pulmonary tuberculosis using host blood protein biomarkers: a systematic review and meta-analysis

Author(s): Kevin Komakech, Derrick Semugenze, Moses Joloba, Frank Cobelens, Willy Ssengooba
Published in: eClinicalMedicine, Issue 84, 2025, ISSN 2589-5370
Publisher: Elsevier BV
DOI: 10.1016/J.ECLINM.2025.103257

Waste to worth: diagnostic accuracy of Xpert MTB/XDR on contaminated liquid cultures to salvage the detection of drug-resistant tuberculosis

Author(s): Yonas Ghebrekristos, Erick Auma, Zama Mahlobo, Rouxjeane Venter, Natalie Beylis, Jay Achar, Brigitta Derendinger, Sarishna Singh, Megan Burger, Christoffel Opperman, Robin Warren, Grant Theron
Published in: Journal of Clinical Microbiology, Issue 63, 2025, ISSN 0095-1137
Publisher: American Society for Microbiology
DOI: 10.1128/JCM.00580-25

Thesis and dissertations (1)

CACO-phony

Author(s): Minette Farrell
Published in: 2025
Publisher: Google Scholar