Fortifying the automated smartphone-based Cough Audio classification for rapid triaGE testing for tuberculosis project

Leistungen

This deliverable was successfully fulfilled in the parent project, CAGE-TB. Nevertheless, we are open to making amendments if deemed necessary in accordance with the terms of this agreement.

Consortium agreement for 4-CAGE-TB

This agreement will be established prior to the commencement of 4-CAGE-TB.

Data analysis plan

The deliverable was successfully completed within the parent project, CAGE-TB. However, we remain open to making amendments if deemed necessary in alignment with the terms of this agreement. Additionally, it is worth noting that this work package will be concluded before the commencement of 4-CAGE-TB.

Communication, dissemination, and exploitation (CDE) plan

This deliverable was successfully fulfilled in the parent project, CAGE-TB. Nevertheless, we are open to making amendments if deemed necessary in accordance with the terms of this agreement.

(Interim) analysis report (implementation research and human centred design)

Report

Standard Operating Procedures

Documents to ensure consistently high-quality work. This deliverable was successfully fulfilled in the parent project, CAGE-TB. Nevertheless, we are open to making amendments if deemed necessary in accordance with the terms of this agreement.

Investigator's brochure

Document describing intervention. The deliverable was successfully completed within the parent project, CAGE-TB. However, we remain open to making amendments if deemed necessary in alignment with the terms of this agreement. Additionally, it is worth noting that this work package will be concluded before the commencement of 4-CAGE-TB.

Monitoring visit plan and quality assurance

Document plan. The deliverable was successfully completed within the parent project, CAGE-TB. However, we remain open to making amendments if deemed necessary in alignment with the terms of this agreement. Additionally, it is worth noting that this work package will be concluded before the commencement of 4-CAGE-TB.

Midterm recruitment report (discovery cohort)

The deliverable was successfully completed within the parent project, CAGE-TB. However, we remain open to making amendments if deemed necessary in alignment with the terms of this agreement. Additionally, it is worth noting that this work package will be concluded before the commencement of 4-CAGE-TB.

Community engagement plan

This deliverable was successfully fulfilled in the parent project, CAGE-TB. Nevertheless, we are open to making amendments if deemed necessary in accordance with the terms of this agreement.

Data transfer agreement

Document. This deliverable was successfully fulfilled in the parent project, CAGE-TB. Nevertheless, we are open to making amendments if deemed necessary in accordance with the terms of this agreement.

All approvals package

The deliverable was successfully completed within the parent project, CAGE-TB. However, we remain open to making amendments if deemed necessary in alignment with the terms of this agreement.

Data management plan (applies to both the discovery and validation cohorts)

Document. This deliverable was successfully fulfilled in the parent project, CAGE-TB. Nevertheless, we are open to making amendments if deemed necessary in accordance with the terms of this agreement.

Procedure for immediate reporting to EDCTP

Document for breaches of data integrity, data protection and privacy, scientific misconduct and ethics. This deliverable was successfully fulfilled in the parent project, CAGE-TB. Nevertheless, we are open to making amendments if deemed necessary in accordance with the terms of this agreement.

Consortium meeting Year 1

Meeting minutes.

Clinical progress plan with projected dates

The deliverable was successfully completed within the parent project, CAGE-TB. However, we remain open to making amendments if deemed necessary in alignment with the terms of this agreement. Additionally, it is worth noting that this work package will be concluded before the commencement of 4-CAGE-TB.

Incidental findings policy

Document describing policy. The deliverable was successfully completed within the parent project, CAGE-TB. However, we remain open to making amendments if deemed necessary in alignment with the terms of this agreement. Additionally, it is worth noting that this work package will be concluded before the commencement of 4-CAGE-TB.

Monitoring visits (including start and close-outs)

Monitoring visit report.

Project plan and Gantt chart with critical path

Gantt chart illustrating critical path. This deliverable was successfully fulfilled in the parent project, CAGE-TB. Nevertheless, the Gantt chart was amended for this project and will be submitted.

Declarations on compliance with national/ EU data legislation

Signed declaration from institutions transferring data. The deliverable was successfully completed within the parent project, CAGE-TB. However, we remain open to making amendments if deemed necessary in alignment with the terms of this agreement. Additionally, it is worth noting that this work package will be concluded before the commencement of 4-CAGE-TB.

Monitoring & Evaluation log and framework

Document. This deliverable was successfully fulfilled in the parent project, CAGE-TB. Nevertheless, we are open to making amendments if deemed necessary in accordance with the terms of this agreement.

Clinical trials insurance

Insurance certificate. The deliverable was successfully completed within the parent project, CAGE-TB. However, we remain open to making amendments if deemed necessary in alignment with the terms of this agreement. Additionally, it is worth noting that this work package will be concluded before the commencement of 4-CAGE-TB.

Registration of clinical study

Link to registration. The deliverable was successfully completed within the parent project, CAGE-TB. However, we remain open to making amendments if deemed necessary in alignment with the terms of this agreement. Additionally, it is worth noting that this work package will be concluded before the commencement of 4-CAGE-TB.

Website

Link to website. This deliverable was successfully fulfilled in the parent project, CAGE-TB. Nevertheless, we are open to making amendments if deemed necessary in accordance with the terms of this agreement.

Veröffentlichungen

Diagnostic Accuracy of LiquidArray MTB-XDR VER 1.0 for the Detection of Mycobacterium tuberculosis Complex, Fluoroquinolone, Amikacin, Ethambutol, and Linezolid Susceptibility

Autoren: Erick Auma, Rencia Alberts, Brigitta Derendinger, Rouxjeane Venter, Elizabeth M Streicher, Samantha Pillay, Yonas T Ghebrekristos, Moses Mburu, Morten Ruhwald, Robin Warren, Adam Penn-Nicholson, Grant Theron, Margaretha de Vos
Veröffentlicht in: Clinical Infectious Diseases, Ausgabe 81, 2025, ISSN 1058-4838
Herausgeber: Oxford University Press (OUP)
DOI: 10.1093/CID/CIAE614

Blood RNA biomarkers and C-reactive protein for triage of adult patients with tuberculosis lymphadenitis and pericarditis in South Africa: a single-centre, prospective, observational, diagnostic accuracy study

Autoren: Tiffeney Mann, Stephanie Minnies, Rishi K Gupta, Byron W P Reeve, Georgina Nyawo, Zaida Palmer, Charissa Naidoo, Anton Doubell, Alfonso Pecoraro, Thadathilankal-Jess John, Pawel Schubert, Claire J Calderwood, Aneesh Chandran, Grant Theron, Mahdad Noursadeghi
Veröffentlicht in: The Lancet Microbe, Ausgabe 6, 2025, ISSN 2666-5247
Herausgeber: Elsevier BV
DOI: 10.1016/J.LANMIC.2025.101153

Diagnostic accuracy of Truenat MTB Ultima on sputum for pulmonary tuberculosis diagnosis in an HIV-endemic setting

Autoren: Shima M. Abdulgader, Arthur M. Chiwaya, Welile V. Nwamba, Byron W.P. Reeve, Zaida Palmer, Hridesh Mishra, Desiree Mbu, Nondumiso Lushozi, Zola Nkwanyana, Morten Ruhwald, Adam Penn-Nicholson, Robin Warren, Grant Theron
Veröffentlicht in: Clinical Microbiology and Infection, Ausgabe 31, 2025, ISSN 1198-743X
Herausgeber: Elsevier BV
DOI: 10.1016/J.CMI.2025.04.013

Xpert MTB/RIF Ultra-resistant and MTBDR plus- susceptible rifampicin results in people with tuberculosis: utility of FluoroType MTBDR and deep sequencing

Autoren: Yonas Ghebrekristos, Aysha Ahmed, Natalie Beylis, Sarishna Singh, Christoffel Opperman, Fahd Naufal, Megan Folkerts, David Engelthaler, Erick Auma, Rouxjeane Venter, Ghowa Booley, John Metcalfe, Robin Warren, Grant Theron
Veröffentlicht in: Antimicrobial Agents and Chemotherapy, Ausgabe 69, 2025, ISSN 0066-4804
Herausgeber: American Society for Microbiology
DOI: 10.1128/AAC.01671-24

Detection of Aerosolized Mycobacterium tuberculosis DNA From Adults Being Investigated for Pulmonary Tuberculosis via an Electrostatic Sampler in a South African Primary Care Setting

Autoren: Jay Achar, Rouxjeane Venter, Jamie van Schalkwyk, Zandile Booi, Zama Mahlobo, Zaida Palmer, Nuno Rufino de Sousa, Knut Lönnroth, James A Seddon, Antonio Gigliotti Rothfuchs, Grant Theron
Veröffentlicht in: Open Forum Infectious Diseases, Ausgabe 12, 2025, ISSN 2328-8957
Herausgeber: Oxford University Press (OUP)
DOI: 10.1093/OFID/OFAF593

Diagnostic accuracy of point-of-care triage tests for pulmonary tuberculosis using host blood protein biomarkers: a systematic review and meta-analysis

Autoren: Kevin Komakech, Derrick Semugenze, Moses Joloba, Frank Cobelens, Willy Ssengooba
Veröffentlicht in: eClinicalMedicine, Ausgabe 84, 2025, ISSN 2589-5370
Herausgeber: Elsevier BV
DOI: 10.1016/J.ECLINM.2025.103257

Waste to worth: diagnostic accuracy of Xpert MTB/XDR on contaminated liquid cultures to salvage the detection of drug-resistant tuberculosis

Autoren: Yonas Ghebrekristos, Erick Auma, Zama Mahlobo, Rouxjeane Venter, Natalie Beylis, Jay Achar, Brigitta Derendinger, Sarishna Singh, Megan Burger, Christoffel Opperman, Robin Warren, Grant Theron
Veröffentlicht in: Journal of Clinical Microbiology, Ausgabe 63, 2025, ISSN 0095-1137
Herausgeber: American Society for Microbiology
DOI: 10.1128/JCM.00580-25

CACO-phony

Autoren: Minette Farrell
Veröffentlicht in: 2025
Herausgeber: Google Scholar

Projektergebnisse

Leistungen

Veröffentlichungen

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